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Article: Dominance of HIV-1 subtype CRF01_AE in sexually acquired cases leads to a new epidemic in Yunnan Province of China

TitleDominance of HIV-1 subtype CRF01_AE in sexually acquired cases leads to a new epidemic in Yunnan Province of China
Authors
Issue Date2006
PublisherPublic Library of Science. The Journal's web site is located at http://medicine.plosjournals.org/perlserv/?request=index-html&issn=1549-1676
Citation
Plos Medicine, 2006, v. 3 n. 11, p. 2065-2077 How to Cite?
AbstractBackground: Dating back to the first epidemic among injection drug users in 1989, the Yunnan province has had the highest number of human immunodeficiency virus type 1 (HIV-1) infections in China. However, the molecular epidemiology of HIV-1 in Yunnan has not been fully characterized. Methods and Findings: Using immunoassays, we identified 103,015 accumulated cases of HIV-1 infections in Yunnan between 1989 and 2004. We studied 321 patients representing Yunnan's 16 prefectures from four risk groups, 11 ethnic populations, and ten occupations. We identified three major circulating subtypes: C/CRF07_BC/CRF08_BC (53%), CRF01_AE (40.5%), and B (6.5%) by analyzing the sequence of p17, which is part of the gag gene. For patients with known risk factors, 90.9% of injection drug users had C/CRF07_BC/CRF08_BC viruses, whereas 85.4% of CRF01_AE infections were acquired through sexual transmission. No distinct segregation of CRF01_AE viruses was found among the Dai ethnic group. Geographically, C/CRF07_BC/CRF08_BC was found throughout the province, while CRF01_AE was largely confined to the prefectures bordering Myanmar. Furthermore, C/CRF07_BC/CRF08_BC viruses were found to consist of a group of viruses, including C, CRF08_BC, CRF07_BC, and new BC recombinants, based on the characterization of their reverse transcriptase genes. Conclusions: This is the first report of a province-wide HIV-1 molecular epidemiological study in Yunnan. While C/CRF07_BC/CRF08_BC and CRF01_AE are codominant, the discovery of many sexually transmitted CRF01_AE cases is new and suggests that this subtype may lead to a new epidemic in the general Chinese population. We discuss implications of our results for understanding the evolution of the HIV-1 pandemic and for vaccine development. © 2006 Zhang et al.
Persistent Identifierhttp://hdl.handle.net/10722/157465
ISSN
2011 Impact Factor: 16.269
2015 SCImago Journal Rankings: 5.667
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, Yen_US
dc.contributor.authorLu, Len_US
dc.contributor.authorBa, Len_US
dc.contributor.authorLiu, Len_US
dc.contributor.authorYang, Len_US
dc.contributor.authorJia, Men_US
dc.contributor.authorWang, Hen_US
dc.contributor.authorFang, Qen_US
dc.contributor.authorShi, Yen_US
dc.contributor.authorYan, Wen_US
dc.contributor.authorChang, Gen_US
dc.contributor.authorZhang, Len_US
dc.contributor.authorHo, DDen_US
dc.contributor.authorChen, Zen_US
dc.date.accessioned2012-08-08T08:50:11Z-
dc.date.available2012-08-08T08:50:11Z-
dc.date.issued2006en_US
dc.identifier.citationPlos Medicine, 2006, v. 3 n. 11, p. 2065-2077en_US
dc.identifier.issn1549-1277en_US
dc.identifier.urihttp://hdl.handle.net/10722/157465-
dc.description.abstractBackground: Dating back to the first epidemic among injection drug users in 1989, the Yunnan province has had the highest number of human immunodeficiency virus type 1 (HIV-1) infections in China. However, the molecular epidemiology of HIV-1 in Yunnan has not been fully characterized. Methods and Findings: Using immunoassays, we identified 103,015 accumulated cases of HIV-1 infections in Yunnan between 1989 and 2004. We studied 321 patients representing Yunnan's 16 prefectures from four risk groups, 11 ethnic populations, and ten occupations. We identified three major circulating subtypes: C/CRF07_BC/CRF08_BC (53%), CRF01_AE (40.5%), and B (6.5%) by analyzing the sequence of p17, which is part of the gag gene. For patients with known risk factors, 90.9% of injection drug users had C/CRF07_BC/CRF08_BC viruses, whereas 85.4% of CRF01_AE infections were acquired through sexual transmission. No distinct segregation of CRF01_AE viruses was found among the Dai ethnic group. Geographically, C/CRF07_BC/CRF08_BC was found throughout the province, while CRF01_AE was largely confined to the prefectures bordering Myanmar. Furthermore, C/CRF07_BC/CRF08_BC viruses were found to consist of a group of viruses, including C, CRF08_BC, CRF07_BC, and new BC recombinants, based on the characterization of their reverse transcriptase genes. Conclusions: This is the first report of a province-wide HIV-1 molecular epidemiological study in Yunnan. While C/CRF07_BC/CRF08_BC and CRF01_AE are codominant, the discovery of many sexually transmitted CRF01_AE cases is new and suggests that this subtype may lead to a new epidemic in the general Chinese population. We discuss implications of our results for understanding the evolution of the HIV-1 pandemic and for vaccine development. © 2006 Zhang et al.en_US
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://medicine.plosjournals.org/perlserv/?request=index-html&issn=1549-1676en_US
dc.relation.ispartofPLoS Medicineen_US
dc.titleDominance of HIV-1 subtype CRF01_AE in sexually acquired cases leads to a new epidemic in Yunnan Province of Chinaen_US
dc.typeArticleen_US
dc.identifier.emailChen, Z:zchenai@hkucc.hku.hken_US
dc.identifier.authorityChen, Z=rp00243en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1371/journal.pmed.0030443en_US
dc.identifier.pmid17105339-
dc.identifier.scopuseid_2-s2.0-33845330854en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33845330854&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume3en_US
dc.identifier.issue11en_US
dc.identifier.spage2065en_US
dc.identifier.epage2077en_US
dc.identifier.isiWOS:000242374800012-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridZhang, Y=7601314112en_US
dc.identifier.scopusauthoridLu, L=25928007500en_US
dc.identifier.scopusauthoridBa, L=8557032300en_US
dc.identifier.scopusauthoridLiu, L=36068379000en_US
dc.identifier.scopusauthoridYang, L=7406275843en_US
dc.identifier.scopusauthoridJia, M=15127030200en_US
dc.identifier.scopusauthoridWang, H=8724886600en_US
dc.identifier.scopusauthoridFang, Q=55248545600en_US
dc.identifier.scopusauthoridShi, Y=7404964022en_US
dc.identifier.scopusauthoridYan, W=35278933800en_US
dc.identifier.scopusauthoridChang, G=15126609900en_US
dc.identifier.scopusauthoridZhang, L=8783285300en_US
dc.identifier.scopusauthoridHo, DD=7402971998en_US
dc.identifier.scopusauthoridChen, Z=35271180800en_US

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