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Article: Clinical outcomes of bacteremic pneumococcal infections in an area with high resistance.
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TitleClinical outcomes of bacteremic pneumococcal infections in an area with high resistance.
 
AuthorsHo, PL1
Que, TL1
Ng, TK1
Chiu, SS1
Yung, RW1
Tsang, KW1
 
Issue Date2006
 
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/10096/index.htm
 
CitationEuropean Journal Of Clinical Microbiology & Infectious Diseases : Official Publication Of The European Society Of Clinical Microbiology, 2006, v. 25 n. 5, p. 323-327 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s10096-006-0139-6
 
AbstractIn a retrospective study designed to gather information in a region with high antimicrobial resistance, the outcomes of 216 episodes of laboratory-confirmed pneumococcal bacteremia treated in Hong Kong between 1995 and 2001 were assessed. The patients had a mean age (+/-standard deviation) of 40+/-33.7 years. In all patients, the clinical diagnosis was confirmed by isolation of Streptococcus pneumoniae from blood (n=216), cerebrospinal fluid (n=7) and/or other sterile sites (n=12). Penicillin nonsusceptibility was found in 37.5% of the isolates (20.8% intermediate and 16.7% resistant). Penicillin nonsusceptibility was not a risk factor for inpatient mortality (p=0.7), nor did it affect duration of fever (p=0.4), requirement for intensive care unit admission (p=0.4) or development of suppurative complications (p=0.2). Advanced age (OR 11.3, 95%CI 4.5-28.2, p<0.01), critical illness (OR 11.3, 95%CI 4.5-28.2, p<0.001) and discordant therapy (OR 4.3, 95%CI 1.7-10.9, p<0.002) involving agents with poor anti-pneumococcal activity (but not penicillins and broad-spectrum beta-lactam agents) were significantly associated with mortality.
 
ISSN0934-9723
2013 Impact Factor: 2.544
 
DOIhttp://dx.doi.org/10.1007/s10096-006-0139-6
 
ISI Accession Number IDWOS:000238445100006
 
DC FieldValue
dc.contributor.authorHo, PL
 
dc.contributor.authorQue, TL
 
dc.contributor.authorNg, TK
 
dc.contributor.authorChiu, SS
 
dc.contributor.authorYung, RW
 
dc.contributor.authorTsang, KW
 
dc.date.accessioned2012-08-08T08:50:04Z
 
dc.date.available2012-08-08T08:50:04Z
 
dc.date.issued2006
 
dc.description.abstractIn a retrospective study designed to gather information in a region with high antimicrobial resistance, the outcomes of 216 episodes of laboratory-confirmed pneumococcal bacteremia treated in Hong Kong between 1995 and 2001 were assessed. The patients had a mean age (+/-standard deviation) of 40+/-33.7 years. In all patients, the clinical diagnosis was confirmed by isolation of Streptococcus pneumoniae from blood (n=216), cerebrospinal fluid (n=7) and/or other sterile sites (n=12). Penicillin nonsusceptibility was found in 37.5% of the isolates (20.8% intermediate and 16.7% resistant). Penicillin nonsusceptibility was not a risk factor for inpatient mortality (p=0.7), nor did it affect duration of fever (p=0.4), requirement for intensive care unit admission (p=0.4) or development of suppurative complications (p=0.2). Advanced age (OR 11.3, 95%CI 4.5-28.2, p<0.01), critical illness (OR 11.3, 95%CI 4.5-28.2, p<0.001) and discordant therapy (OR 4.3, 95%CI 1.7-10.9, p<0.002) involving agents with poor anti-pneumococcal activity (but not penicillins and broad-spectrum beta-lactam agents) were significantly associated with mortality.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationEuropean Journal Of Clinical Microbiology & Infectious Diseases : Official Publication Of The European Society Of Clinical Microbiology, 2006, v. 25 n. 5, p. 323-327 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s10096-006-0139-6
 
dc.identifier.doihttp://dx.doi.org/10.1007/s10096-006-0139-6
 
dc.identifier.epage327
 
dc.identifier.hkuros118612
 
dc.identifier.isiWOS:000238445100006
 
dc.identifier.issn0934-9723
2013 Impact Factor: 2.544
 
dc.identifier.issue5
 
dc.identifier.pmid16786378
 
dc.identifier.scopuseid_2-s2.0-33746741845
 
dc.identifier.spage323
 
dc.identifier.urihttp://hdl.handle.net/10722/157451
 
dc.identifier.volume25
 
dc.languageeng
 
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/10096/index.htm
 
dc.publisher.placeGermany
 
dc.relation.ispartofEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
 
dc.subject.meshAdolescent
 
dc.subject.meshAdult
 
dc.subject.meshAged
 
dc.subject.meshBacteremia - Drug Therapy - Microbiology
 
dc.subject.meshChild
 
dc.subject.meshChild, Preschool
 
dc.subject.meshCohort Studies
 
dc.subject.meshDrug Resistance
 
dc.subject.meshFemale
 
dc.subject.meshHumans
 
dc.subject.meshInfant
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshPneumococcal Infections - Drug Therapy - Microbiology
 
dc.subject.meshRetrospective Studies
 
dc.subject.meshStreptococcus Pneumoniae - Isolation & Purification
 
dc.subject.meshTreatment Outcome
 
dc.titleClinical outcomes of bacteremic pneumococcal infections in an area with high resistance.
 
dc.typeArticle
 
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<item><contributor.author>Ho, PL</contributor.author>
<contributor.author>Que, TL</contributor.author>
<contributor.author>Ng, TK</contributor.author>
<contributor.author>Chiu, SS</contributor.author>
<contributor.author>Yung, RW</contributor.author>
<contributor.author>Tsang, KW</contributor.author>
<date.accessioned>2012-08-08T08:50:04Z</date.accessioned>
<date.available>2012-08-08T08:50:04Z</date.available>
<date.issued>2006</date.issued>
<identifier.citation>European Journal Of Clinical Microbiology &amp; Infectious Diseases : Official Publication Of The European Society Of Clinical Microbiology, 2006, v. 25 n. 5, p. 323-327</identifier.citation>
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<description.abstract>In a retrospective study designed to gather information in a region with high antimicrobial resistance, the outcomes of 216 episodes of laboratory-confirmed pneumococcal bacteremia treated in Hong Kong between 1995 and 2001 were assessed. The patients had a mean age (+/-standard deviation) of 40+/-33.7 years. In all patients, the clinical diagnosis was confirmed by isolation of Streptococcus pneumoniae from blood (n=216), cerebrospinal fluid (n=7) and/or other sterile sites (n=12). Penicillin nonsusceptibility was found in 37.5% of the isolates (20.8% intermediate and 16.7% resistant). Penicillin nonsusceptibility was not a risk factor for inpatient mortality (p=0.7), nor did it affect duration of fever (p=0.4), requirement for intensive care unit admission (p=0.4) or development of suppurative complications (p=0.2). Advanced age (OR 11.3, 95%CI 4.5-28.2, p&lt;0.01), critical illness (OR 11.3, 95%CI 4.5-28.2, p&lt;0.001) and discordant therapy (OR 4.3, 95%CI 1.7-10.9, p&lt;0.002) involving agents with poor anti-pneumococcal activity (but not penicillins and broad-spectrum beta-lactam agents) were significantly associated with mortality.</description.abstract>
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<subject.mesh>Adolescent</subject.mesh>
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<subject.mesh>Aged</subject.mesh>
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<subject.mesh>Child</subject.mesh>
<subject.mesh>Child, Preschool</subject.mesh>
<subject.mesh>Cohort Studies</subject.mesh>
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<subject.mesh>Female</subject.mesh>
<subject.mesh>Humans</subject.mesh>
<subject.mesh>Infant</subject.mesh>
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<subject.mesh>Retrospective Studies</subject.mesh>
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Author Affiliations
  1. The University of Hong Kong