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Article: Clinical outcomes of bacteremic pneumococcal infections in an area with high resistance.

TitleClinical outcomes of bacteremic pneumococcal infections in an area with high resistance.
Authors
Issue Date2006
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/10096/index.htm
Citation
European Journal Of Clinical Microbiology & Infectious Diseases : Official Publication Of The European Society Of Clinical Microbiology, 2006, v. 25 n. 5, p. 323-327 How to Cite?
Abstract
In a retrospective study designed to gather information in a region with high antimicrobial resistance, the outcomes of 216 episodes of laboratory-confirmed pneumococcal bacteremia treated in Hong Kong between 1995 and 2001 were assessed. The patients had a mean age (+/-standard deviation) of 40+/-33.7 years. In all patients, the clinical diagnosis was confirmed by isolation of Streptococcus pneumoniae from blood (n=216), cerebrospinal fluid (n=7) and/or other sterile sites (n=12). Penicillin nonsusceptibility was found in 37.5% of the isolates (20.8% intermediate and 16.7% resistant). Penicillin nonsusceptibility was not a risk factor for inpatient mortality (p=0.7), nor did it affect duration of fever (p=0.4), requirement for intensive care unit admission (p=0.4) or development of suppurative complications (p=0.2). Advanced age (OR 11.3, 95%CI 4.5-28.2, p<0.01), critical illness (OR 11.3, 95%CI 4.5-28.2, p<0.001) and discordant therapy (OR 4.3, 95%CI 1.7-10.9, p<0.002) involving agents with poor anti-pneumococcal activity (but not penicillins and broad-spectrum beta-lactam agents) were significantly associated with mortality.
Persistent Identifierhttp://hdl.handle.net/10722/157451
ISSN
2013 Impact Factor: 2.544
ISI Accession Number ID

 

Author Affiliations
  1. The University of Hong Kong
DC FieldValueLanguage
dc.contributor.authorHo, PLen_US
dc.contributor.authorQue, TLen_US
dc.contributor.authorNg, TKen_US
dc.contributor.authorChiu, SSen_US
dc.contributor.authorYung, RWen_US
dc.contributor.authorTsang, KWen_US
dc.date.accessioned2012-08-08T08:50:04Z-
dc.date.available2012-08-08T08:50:04Z-
dc.date.issued2006en_US
dc.identifier.citationEuropean Journal Of Clinical Microbiology & Infectious Diseases : Official Publication Of The European Society Of Clinical Microbiology, 2006, v. 25 n. 5, p. 323-327en_US
dc.identifier.issn0934-9723en_US
dc.identifier.urihttp://hdl.handle.net/10722/157451-
dc.description.abstractIn a retrospective study designed to gather information in a region with high antimicrobial resistance, the outcomes of 216 episodes of laboratory-confirmed pneumococcal bacteremia treated in Hong Kong between 1995 and 2001 were assessed. The patients had a mean age (+/-standard deviation) of 40+/-33.7 years. In all patients, the clinical diagnosis was confirmed by isolation of Streptococcus pneumoniae from blood (n=216), cerebrospinal fluid (n=7) and/or other sterile sites (n=12). Penicillin nonsusceptibility was found in 37.5% of the isolates (20.8% intermediate and 16.7% resistant). Penicillin nonsusceptibility was not a risk factor for inpatient mortality (p=0.7), nor did it affect duration of fever (p=0.4), requirement for intensive care unit admission (p=0.4) or development of suppurative complications (p=0.2). Advanced age (OR 11.3, 95%CI 4.5-28.2, p<0.01), critical illness (OR 11.3, 95%CI 4.5-28.2, p<0.001) and discordant therapy (OR 4.3, 95%CI 1.7-10.9, p<0.002) involving agents with poor anti-pneumococcal activity (but not penicillins and broad-spectrum beta-lactam agents) were significantly associated with mortality.en_US
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/10096/index.htmen_US
dc.relation.ispartofEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBacteremia - Drug Therapy - Microbiologyen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshDrug Resistanceen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPneumococcal Infections - Drug Therapy - Microbiologyen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshStreptococcus Pneumoniae - Isolation & Purificationen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleClinical outcomes of bacteremic pneumococcal infections in an area with high resistance.en_US
dc.typeArticleen_US
dc.identifier.emailHo, PL:plho@hkucc.hku.hken_US
dc.identifier.emailChiu, SS:ssschiu@hkucc.hku.hken_US
dc.identifier.authorityHo, PL=rp00406en_US
dc.identifier.authorityChiu, SS=rp00421en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s10096-006-0139-6en_US
dc.identifier.pmid16786378en_US
dc.identifier.scopuseid_2-s2.0-33746741845en_US
dc.identifier.hkuros118612-
dc.identifier.volume25en_US
dc.identifier.issue5en_US
dc.identifier.spage323en_US
dc.identifier.epage327en_US
dc.identifier.isiWOS:000238445100006-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridHo, PL=7402211363en_US
dc.identifier.scopusauthoridQue, TL=7003786628en_US
dc.identifier.scopusauthoridNg, TK=7402229817en_US
dc.identifier.scopusauthoridChiu, SS=7202291500en_US
dc.identifier.scopusauthoridYung, RW=7005594277en_US
dc.identifier.scopusauthoridTsang, KW=7201555024en_US

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