Article: Clinical outcomes of bacteremic pneumococcal infections in an area with high resistance.

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TitleClinical outcomes of bacteremic pneumococcal infections in an area with high resistance.
AuthorsHo, PL1
Que, TL1
Ng, TK1
Chiu, SS1
Yung, RW1
Tsang, KW1
Issue Date2006
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/10096/index.htm
CitationEuropean Journal Of Clinical Microbiology & Infectious Diseases : Official Publication Of The European Society Of Clinical Microbiology, 2006, v. 25 n. 5, p. 323-327 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s10096-006-0139-6
AbstractIn a retrospective study designed to gather information in a region with high antimicrobial resistance, the outcomes of 216 episodes of laboratory-confirmed pneumococcal bacteremia treated in Hong Kong between 1995 and 2001 were assessed. The patients had a mean age (+/-standard deviation) of 40+/-33.7 years. In all patients, the clinical diagnosis was confirmed by isolation of Streptococcus pneumoniae from blood (n=216), cerebrospinal fluid (n=7) and/or other sterile sites (n=12). Penicillin nonsusceptibility was found in 37.5% of the isolates (20.8% intermediate and 16.7% resistant). Penicillin nonsusceptibility was not a risk factor for inpatient mortality (p=0.7), nor did it affect duration of fever (p=0.4), requirement for intensive care unit admission (p=0.4) or development of suppurative complications (p=0.2). Advanced age (OR 11.3, 95%CI 4.5-28.2, p<0.01), critical illness (OR 11.3, 95%CI 4.5-28.2, p<0.001) and discordant therapy (OR 4.3, 95%CI 1.7-10.9, p<0.002) involving agents with poor anti-pneumococcal activity (but not penicillins and broad-spectrum beta-lactam agents) were significantly associated with mortality.
ISSN0934-9723
2011 Impact Factor: 2.859
2011 SCImago Journal Rankings: 0.215
DOIhttp://dx.doi.org/10.1007/s10096-006-0139-6
ISI Accession Number IDWOS:000238445100006
DC Field
Value
dc.contributor.authorHo, PL
dc.contributor.authorQue, TL
dc.contributor.authorNg, TK
dc.contributor.authorChiu, SS
dc.contributor.authorYung, RW
dc.contributor.authorTsang, KW
dc.date.accessioned2012-08-08T08:50:04Z
dc.date.available2012-08-08T08:50:04Z
dc.date.issued2006
dc.description.abstractIn a retrospective study designed to gather information in a region with high antimicrobial resistance, the outcomes of 216 episodes of laboratory-confirmed pneumococcal bacteremia treated in Hong Kong between 1995 and 2001 were assessed. The patients had a mean age (+/-standard deviation) of 40+/-33.7 years. In all patients, the clinical diagnosis was confirmed by isolation of Streptococcus pneumoniae from blood (n=216), cerebrospinal fluid (n=7) and/or other sterile sites (n=12). Penicillin nonsusceptibility was found in 37.5% of the isolates (20.8% intermediate and 16.7% resistant). Penicillin nonsusceptibility was not a risk factor for inpatient mortality (p=0.7), nor did it affect duration of fever (p=0.4), requirement for intensive care unit admission (p=0.4) or development of suppurative complications (p=0.2). Advanced age (OR 11.3, 95%CI 4.5-28.2, p<0.01), critical illness (OR 11.3, 95%CI 4.5-28.2, p<0.001) and discordant therapy (OR 4.3, 95%CI 1.7-10.9, p<0.002) involving agents with poor anti-pneumococcal activity (but not penicillins and broad-spectrum beta-lactam agents) were significantly associated with mortality.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationEuropean Journal Of Clinical Microbiology & Infectious Diseases : Official Publication Of The European Society Of Clinical Microbiology, 2006, v. 25 n. 5, p. 323-327 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s10096-006-0139-6
dc.identifier.doihttp://dx.doi.org/10.1007/s10096-006-0139-6
dc.identifier.epage327
dc.identifier.hkuros118612
dc.identifier.isiWOS:000238445100006
dc.identifier.issn0934-9723
2011 Impact Factor: 2.859
2011 SCImago Journal Rankings: 0.215
dc.identifier.issue5
dc.identifier.pmid16786378
dc.identifier.scopuseid_2-s2.0-33746741845
dc.identifier.spage323
dc.identifier.urihttp://hdl.handle.net/10722/157451
dc.identifier.volume25
dc.languageeng
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/10096/index.htm
dc.publisher.placeGermany
dc.relation.ispartofEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshBacteremia - Drug Therapy - Microbiology
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshCohort Studies
dc.subject.meshDrug Resistance
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshInfant
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPneumococcal Infections - Drug Therapy - Microbiology
dc.subject.meshRetrospective Studies
dc.subject.meshStreptococcus Pneumoniae - Isolation & Purification
dc.subject.meshTreatment Outcome
dc.titleClinical outcomes of bacteremic pneumococcal infections in an area with high resistance.
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong