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Article: Lymphopenia at presentation is associated with increased risk of infections in patients with systemic lupus erythematosus

TitleLymphopenia at presentation is associated with increased risk of infections in patients with systemic lupus erythematosus
Authors
Issue Date2006
PublisherOxford University Press. The Journal's web site is located at http://qjmed.oxfordjournals.org/
Citation
Qjm - Monthly Journal Of The Association Of Physicians, 2006, v. 99 n. 1, p. 37-47 How to Cite?
AbstractBackground: Patients with systemic lupus erythematosus (SLE) frequently suffer from infections, but the predisposing risk factors, as well as the exact frequency and nature of such infections, are not fully understood. Aim: To describe the frequency, types and risk factors for infections in a group of Chinese patients in the early stage of SLE in Hong Kong. Design: Retrospective record study. Methods: We reviewed the case records of 91 Chinese SLE patients, presenting <12 months after SLE diagnosis. Details of major infections (requiring intravenous antimicrobial therapy, or any confirmed mycobacterial infection) and minor infections were reviewed. Clinical and laboratory features, the systemic lupus erythematosus disease activity index (SLEDAI) at presentation and drug treatment were recorded and analysed. Results: There were 48 major infections and 62minor infections during 260 patient-years of follow-up. A lymphocyte count ≤1.0 × 10 9/l at presentation was independently associated with an increased risk for major infection: hazard ratio 4.7 (95%CI 1.6-13.7), p=0.005. SLEDAI, use of corticosteroids and immunosuppressive therapy were all not associated with increased risk of infection. Discussion: Lymphopenia was an important risk factor for major infections in this group of Chinese patients in the early stages of SLE. SLE patients with lymphopenia at presentation should be closely monitored for the development of infective complications. © The Author 2006. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/157434
ISSN
2015 Impact Factor: 2.824
2015 SCImago Journal Rankings: 0.633
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNg, WLen_US
dc.contributor.authorChu, CMen_US
dc.contributor.authorWu, AKLen_US
dc.contributor.authorCheng, VCCen_US
dc.contributor.authorYuen, KYen_US
dc.date.accessioned2012-08-08T08:49:56Z-
dc.date.available2012-08-08T08:49:56Z-
dc.date.issued2006en_US
dc.identifier.citationQjm - Monthly Journal Of The Association Of Physicians, 2006, v. 99 n. 1, p. 37-47en_US
dc.identifier.issn1460-2725en_US
dc.identifier.urihttp://hdl.handle.net/10722/157434-
dc.description.abstractBackground: Patients with systemic lupus erythematosus (SLE) frequently suffer from infections, but the predisposing risk factors, as well as the exact frequency and nature of such infections, are not fully understood. Aim: To describe the frequency, types and risk factors for infections in a group of Chinese patients in the early stage of SLE in Hong Kong. Design: Retrospective record study. Methods: We reviewed the case records of 91 Chinese SLE patients, presenting <12 months after SLE diagnosis. Details of major infections (requiring intravenous antimicrobial therapy, or any confirmed mycobacterial infection) and minor infections were reviewed. Clinical and laboratory features, the systemic lupus erythematosus disease activity index (SLEDAI) at presentation and drug treatment were recorded and analysed. Results: There were 48 major infections and 62minor infections during 260 patient-years of follow-up. A lymphocyte count ≤1.0 × 10 9/l at presentation was independently associated with an increased risk for major infection: hazard ratio 4.7 (95%CI 1.6-13.7), p=0.005. SLEDAI, use of corticosteroids and immunosuppressive therapy were all not associated with increased risk of infection. Discussion: Lymphopenia was an important risk factor for major infections in this group of Chinese patients in the early stages of SLE. SLE patients with lymphopenia at presentation should be closely monitored for the development of infective complications. © The Author 2006. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://qjmed.oxfordjournals.org/en_US
dc.relation.ispartofQJM - Monthly Journal of the Association of Physiciansen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshChilden_US
dc.subject.meshFemaleen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshLupus Erythematosus, Systemic - Complicationsen_US
dc.subject.meshLymphopenia - Complicationsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOpportunistic Infections - Etiologyen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshRisk Factorsen_US
dc.titleLymphopenia at presentation is associated with increased risk of infections in patients with systemic lupus erythematosusen_US
dc.typeArticleen_US
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_US
dc.identifier.authorityYuen, KY=rp00366en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1093/qjmed/hci155en_US
dc.identifier.pmid16371405-
dc.identifier.scopuseid_2-s2.0-31144450174en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-31144450174&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume99en_US
dc.identifier.issue1en_US
dc.identifier.spage37en_US
dc.identifier.epage47en_US
dc.identifier.isiWOS:000234218300005-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridNg, WL=7401613401en_US
dc.identifier.scopusauthoridChu, CM=7404345558en_US
dc.identifier.scopusauthoridWu, AKL=7402998681en_US
dc.identifier.scopusauthoridCheng, VCC=23670479400en_US
dc.identifier.scopusauthoridYuen, KY=36078079100en_US
dc.identifier.citeulike449943-

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