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Article: Fluoroquinolone and other antimicriobial resistance in invasive pneumococci, Hong Kong, 1995-2001
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TitleFluoroquinolone and other antimicriobial resistance in invasive pneumococci, Hong Kong, 1995-2001
 
AuthorsHo, PL1
Que, TL3
Chiu, SS1
Yung, RWH5
Ng, TK2
Tsang, DNC4
Seto, WH1
Lau, YL1
 
Issue Date2004
 
PublisherUS Department of Health and Human Services, Centers for Disease Control and Prevention. The Journal's web site is located at http://www.cdc.gov/ncidod/EID/index.htm
 
CitationEmerging Infectious Diseases, 2004, v. 10 n. 7, p. 1250-1257 [How to Cite?]
 
AbstractWe determined the susceptibilities of 265 invasive isolates of pneumococci obtained during 1995 to 2001 in Hong Kong to 11 antimicrobial agents and their serotypes. Overall, 62.6% isolates were susceptible to penicillin, 20% were intermediately resistant, and 17.4% were resistant. The overall prevalence of levofloxacin resistance (MIC ≥8 μg/mL) was 3.8% but increased to 15.2% among the penicillin-resistant isolates. All levofloxacin-resistant isolates were clonally related; had reduced susceptibility to penicillin, cefotaxime, and clarithromycin; and were derived from adults >50 years of age. Of the penicillin-nonsusceptible pneumococci, 90% from children ≤5 years of age and 54.8% from persons of all ages were of serotypes that are included in the 7-valent pneumococcal conjugate vaccine; 93.5% from children ≤5 years of age and 93% from persons of all ages were of serotypes that are included in the 23-valent polysaccharide vaccine.
 
ISSN1080-6040
2013 Impact Factor: 7.327
 
ISI Accession Number IDWOS:000222456800010
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorHo, PL
 
dc.contributor.authorQue, TL
 
dc.contributor.authorChiu, SS
 
dc.contributor.authorYung, RWH
 
dc.contributor.authorNg, TK
 
dc.contributor.authorTsang, DNC
 
dc.contributor.authorSeto, WH
 
dc.contributor.authorLau, YL
 
dc.date.accessioned2012-08-08T08:49:55Z
 
dc.date.available2012-08-08T08:49:55Z
 
dc.date.issued2004
 
dc.description.abstractWe determined the susceptibilities of 265 invasive isolates of pneumococci obtained during 1995 to 2001 in Hong Kong to 11 antimicrobial agents and their serotypes. Overall, 62.6% isolates were susceptible to penicillin, 20% were intermediately resistant, and 17.4% were resistant. The overall prevalence of levofloxacin resistance (MIC ≥8 μg/mL) was 3.8% but increased to 15.2% among the penicillin-resistant isolates. All levofloxacin-resistant isolates were clonally related; had reduced susceptibility to penicillin, cefotaxime, and clarithromycin; and were derived from adults >50 years of age. Of the penicillin-nonsusceptible pneumococci, 90% from children ≤5 years of age and 54.8% from persons of all ages were of serotypes that are included in the 7-valent pneumococcal conjugate vaccine; 93.5% from children ≤5 years of age and 93% from persons of all ages were of serotypes that are included in the 23-valent polysaccharide vaccine.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationEmerging Infectious Diseases, 2004, v. 10 n. 7, p. 1250-1257 [How to Cite?]
 
dc.identifier.epage1257
 
dc.identifier.hkuros94814
 
dc.identifier.isiWOS:000222456800010
 
dc.identifier.issn1080-6040
2013 Impact Factor: 7.327
 
dc.identifier.issue7
 
dc.identifier.pmid15324545
 
dc.identifier.scopuseid_2-s2.0-3042703738
 
dc.identifier.spage1250
 
dc.identifier.urihttp://hdl.handle.net/10722/157433
 
dc.identifier.volume10
 
dc.languageeng
 
dc.publisherUS Department of Health and Human Services, Centers for Disease Control and Prevention. The Journal's web site is located at http://www.cdc.gov/ncidod/EID/index.htm
 
dc.publisher.placeUnited States
 
dc.relation.ispartofEmerging Infectious Diseases
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdolescent
 
dc.subject.meshAdult
 
dc.subject.meshAnti-Bacterial Agents - Pharmacology
 
dc.subject.meshChild
 
dc.subject.meshChild, Preschool
 
dc.subject.meshDrug Resistance, Bacterial - Genetics
 
dc.subject.meshFluoroquinolones - Pharmacology
 
dc.subject.meshHong Kong - Epidemiology
 
dc.subject.meshHumans
 
dc.subject.meshMicrobial Sensitivity Tests
 
dc.subject.meshMiddle Aged
 
dc.subject.meshPneumococcal Infections - Epidemiology - Microbiology
 
dc.subject.meshSerotyping
 
dc.subject.meshStreptococcus Pneumoniae - Classification - Drug Effects
 
dc.titleFluoroquinolone and other antimicriobial resistance in invasive pneumococci, Hong Kong, 1995-2001
 
dc.typeArticle
 
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<contributor.author>Ng, TK</contributor.author>
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Author Affiliations
  1. The University of Hong Kong
  2. Princess Margaret Hospital Hong Kong
  3. Tuen Mun Hospital
  4. Queen Elizabeth Hospital Hong Kong
  5. Pamela Youde Nethersole Eastern Hospital