Article: Fluoroquinolone and other antimicriobial resistance in invasive pneumococci, Hong Kong, 1995-2001

File Download Links for fulltext
(May Require Subscription)
Supplementary
  • Basic View
  • Metadata View
  • XML View
TitleFluoroquinolone and other antimicriobial resistance in invasive pneumococci, Hong Kong, 1995-2001
AuthorsHo, PL2
Que, TL1
Chiu, SS2
Yung, RWH5
Ng, TK3
Tsang, DNC4
Seto, WH2
Lau, YL2
Issue Date2004
PublisherUS Department of Health and Human Services, Centers for Disease Control and Prevention. The Journal's web site is located at http://www.cdc.gov/ncidod/EID/index.htm
CitationEmerging Infectious Diseases, 2004, v. 10 n. 7, p. 1250-1257 [How to Cite?]
AbstractWe determined the susceptibilities of 265 invasive isolates of pneumococci obtained during 1995 to 2001 in Hong Kong to 11 antimicrobial agents and their serotypes. Overall, 62.6% isolates were susceptible to penicillin, 20% were intermediately resistant, and 17.4% were resistant. The overall prevalence of levofloxacin resistance (MIC ≥8 μg/mL) was 3.8% but increased to 15.2% among the penicillin-resistant isolates. All levofloxacin-resistant isolates were clonally related; had reduced susceptibility to penicillin, cefotaxime, and clarithromycin; and were derived from adults >50 years of age. Of the penicillin-nonsusceptible pneumococci, 90% from children ≤5 years of age and 54.8% from persons of all ages were of serotypes that are included in the 7-valent pneumococcal conjugate vaccine; 93.5% from children ≤5 years of age and 93% from persons of all ages were of serotypes that are included in the 23-valent polysaccharide vaccine.
ISSN1080-6040
2011 Impact Factor: 6.169
2011 SCImago Journal Rankings: 0.476
ISI Accession Number IDWOS:000222456800010
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorHo, PL
dc.contributor.authorQue, TL
dc.contributor.authorChiu, SS
dc.contributor.authorYung, RWH
dc.contributor.authorNg, TK
dc.contributor.authorTsang, DNC
dc.contributor.authorSeto, WH
dc.contributor.authorLau, YL
dc.date.accessioned2012-08-08T08:49:55Z
dc.date.available2012-08-08T08:49:55Z
dc.date.issued2004
dc.description.abstractWe determined the susceptibilities of 265 invasive isolates of pneumococci obtained during 1995 to 2001 in Hong Kong to 11 antimicrobial agents and their serotypes. Overall, 62.6% isolates were susceptible to penicillin, 20% were intermediately resistant, and 17.4% were resistant. The overall prevalence of levofloxacin resistance (MIC ≥8 μg/mL) was 3.8% but increased to 15.2% among the penicillin-resistant isolates. All levofloxacin-resistant isolates were clonally related; had reduced susceptibility to penicillin, cefotaxime, and clarithromycin; and were derived from adults >50 years of age. Of the penicillin-nonsusceptible pneumococci, 90% from children ≤5 years of age and 54.8% from persons of all ages were of serotypes that are included in the 7-valent pneumococcal conjugate vaccine; 93.5% from children ≤5 years of age and 93% from persons of all ages were of serotypes that are included in the 23-valent polysaccharide vaccine.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationEmerging Infectious Diseases, 2004, v. 10 n. 7, p. 1250-1257 [How to Cite?]
dc.identifier.epage1257
dc.identifier.hkuros94814
dc.identifier.isiWOS:000222456800010
dc.identifier.issn1080-6040
2011 Impact Factor: 6.169
2011 SCImago Journal Rankings: 0.476
dc.identifier.issue7
dc.identifier.pmid15324545
dc.identifier.scopuseid_2-s2.0-3042703738
dc.identifier.spage1250
dc.identifier.urihttp://hdl.handle.net/10722/157433
dc.identifier.volume10
dc.languageeng
dc.publisherUS Department of Health and Human Services, Centers for Disease Control and Prevention. The Journal's web site is located at http://www.cdc.gov/ncidod/EID/index.htm
dc.publisher.placeUnited States
dc.relation.ispartofEmerging Infectious Diseases
dc.relation.referencesReferences in Scopus
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAnti-Bacterial Agents - Pharmacology
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshDrug Resistance, Bacterial - Genetics
dc.subject.meshFluoroquinolones - Pharmacology
dc.subject.meshHong Kong - Epidemiology
dc.subject.meshHumans
dc.subject.meshMicrobial Sensitivity Tests
dc.subject.meshMiddle Aged
dc.subject.meshPneumococcal Infections - Epidemiology - Microbiology
dc.subject.meshSerotyping
dc.subject.meshStreptococcus Pneumoniae - Classification - Drug Effects
dc.titleFluoroquinolone and other antimicriobial resistance in invasive pneumococci, Hong Kong, 1995-2001
dc.typeArticle
Author Affiliations
  1. Tuen Mun Hospital
  2. The University of Hong Kong
  3. Princess Margaret Hospital Hong Kong
  4. Queen Elizabeth Hospital Hong Kong
  5. Pamela Youde Nethersole Eastern Hospital