Article: Association of Laribacter hongkongensis in community-acquired gastroenteritis with travel and eating fish: A multicentre case-control study

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TitleAssociation of Laribacter hongkongensis in community-acquired gastroenteritis with travel and eating fish: A multicentre case-control study
AuthorsWoo, PCY3
Lau, SKP3
Teng, JLL3
Que, TL2
Yung, RWH4
Luk, WK1
Lai, RWM5
Hui, WT3
Wong, SSY3
Yau, HH2
Yuen, KY3
Issue Date2004
PublisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lancet
CitationLancet, 2004, v. 363 n. 9425, p. 1941-1947 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0140-6736(04)16407-6
AbstractBackground Laribacter hongkongensis has been recovered from several patients with gastroenteritis. However, the causative role of this organism in human gastroenteritis is still unproven, and sources of the bacterium are unknown. We undertook a multicentre case-control study to investigate the association of L hongkongensis with gastroenteritis. Methods Faecal samples from patients with community-acquired gastroenteritis and controls were cultured for L hongkongensis. Targeted food surveillance was done to identify potential sources of this bacterium. All isolates of this organism from patients and food items were characterised by pulsed-field gel electrophoresis and ribotyping. Findings During a 4-month period, L hongkongensis was recovered from 17 of 3788 patients with community-acquired gastroenteritis, but was absent in 1894 controls (p=0·001). Those who were culture-positive for this bacterium had a recent history of travel (ten [59%] patients vs two [6%] of 34 matched controls, p<0·0001), of fish consumption (16 [94%] vs 19 [56%], p=0·009), and of eating minced freshwater fish meat (five [29%] vs one [3%], p=0·012). We recovered 25 L hongkongensis isolates from intestinal samples of freshwater fish and two from minced freshwater fish meat. Bacteria with the same pulsed-field gel electrophoretic pattern and ribotype were recovered from one patient and a sample of minced freshwater fish meat, which was from the same retail market recently visited by the patient. We did not see this particular combination of electrophoretic pattern and ribotype in any other isolates. Interpretation L hongkongensis is associated with community-acquired gastroenteritis and traveller's diarrhoea. However, its causative role has not been shown. Freshwater fish is one source of this bacterium.
ISSN0140-6736
2011 Impact Factor: 38.278
2011 SCImago Journal Rankings: 1.486
DOIhttp://dx.doi.org/10.1016/S0140-6736(04)16407-6
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorWoo, PCY
dc.contributor.authorLau, SKP
dc.contributor.authorTeng, JLL
dc.contributor.authorQue, TL
dc.contributor.authorYung, RWH
dc.contributor.authorLuk, WK
dc.contributor.authorLai, RWM
dc.contributor.authorHui, WT
dc.contributor.authorWong, SSY
dc.contributor.authorYau, HH
dc.contributor.authorYuen, KY
dc.date.accessioned2012-08-08T08:49:53Z
dc.date.available2012-08-08T08:49:53Z
dc.date.issued2004
dc.description.abstractBackground Laribacter hongkongensis has been recovered from several patients with gastroenteritis. However, the causative role of this organism in human gastroenteritis is still unproven, and sources of the bacterium are unknown. We undertook a multicentre case-control study to investigate the association of L hongkongensis with gastroenteritis. Methods Faecal samples from patients with community-acquired gastroenteritis and controls were cultured for L hongkongensis. Targeted food surveillance was done to identify potential sources of this bacterium. All isolates of this organism from patients and food items were characterised by pulsed-field gel electrophoresis and ribotyping. Findings During a 4-month period, L hongkongensis was recovered from 17 of 3788 patients with community-acquired gastroenteritis, but was absent in 1894 controls (p=0·001). Those who were culture-positive for this bacterium had a recent history of travel (ten [59%] patients vs two [6%] of 34 matched controls, p<0·0001), of fish consumption (16 [94%] vs 19 [56%], p=0·009), and of eating minced freshwater fish meat (five [29%] vs one [3%], p=0·012). We recovered 25 L hongkongensis isolates from intestinal samples of freshwater fish and two from minced freshwater fish meat. Bacteria with the same pulsed-field gel electrophoretic pattern and ribotype were recovered from one patient and a sample of minced freshwater fish meat, which was from the same retail market recently visited by the patient. We did not see this particular combination of electrophoretic pattern and ribotype in any other isolates. Interpretation L hongkongensis is associated with community-acquired gastroenteritis and traveller's diarrhoea. However, its causative role has not been shown. Freshwater fish is one source of this bacterium.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationLancet, 2004, v. 363 n. 9425, p. 1941-1947 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0140-6736(04)16407-6
dc.identifier.doihttp://dx.doi.org/10.1016/S0140-6736(04)16407-6
dc.identifier.epage1947
dc.identifier.isiWOS:000221962800008
dc.identifier.issn0140-6736
2011 Impact Factor: 38.278
2011 SCImago Journal Rankings: 1.486
dc.identifier.issue9425
dc.identifier.pmid15194253
dc.identifier.scopuseid_2-s2.0-2942601556
dc.identifier.spage1941
dc.identifier.urihttp://hdl.handle.net/10722/157430
dc.identifier.volume363
dc.languageeng
dc.publisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lancet
dc.publisher.placeUnited Kingdom
dc.relation.ispartofLancet
dc.relation.referencesReferences in Scopus
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAged, 80 And Over
dc.subject.meshAnimals
dc.subject.meshCase-Control Studies
dc.subject.meshCommunity-Acquired Infections - Microbiology
dc.subject.meshDiarrhea - Microbiology
dc.subject.meshElectrophoresis, Gel, Pulsed-Field
dc.subject.meshFeces - Microbiology
dc.subject.meshFemale
dc.subject.meshFishes - Microbiology
dc.subject.meshFood Microbiology
dc.subject.meshGastroenteritis - Microbiology
dc.subject.meshHumans
dc.subject.meshInfant
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshNeisseriaceae - Classification - Genetics - Isolation & Purification
dc.subject.meshNeisseriaceae Infections - Microbiology - Transmission
dc.subject.meshRna, Bacterial - Genetics
dc.subject.meshRisk Factors
dc.subject.meshSequence Analysis, Rna
dc.subject.meshTravel
dc.titleAssociation of Laribacter hongkongensis in community-acquired gastroenteritis with travel and eating fish: A multicentre case-control study
dc.typeArticle
Author Affiliations
  1. Tseung Kwan O Hospital
  2. Tuen Mun Hospital
  3. The University of Hong Kong
  4. Pamela Youde Nethersole Eastern Hospital
  5. United Christian Hospital Hong Kong