Article: Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals

File Download Links for fulltext
(May Require Subscription)
Supplementary
  • Basic View
  • Metadata View
  • XML View
TitleAntibody responses against SARS coronavirus are correlated with disease outcome of infected individuals
AuthorsZhang, L3 4 5
Zhang, F5
Yu, W5
He, T5
Yu, J5
Yi, CE5
Ba, L5
Li, W1
Farzan, M1
Chen, Z5
Yuen, KY2
Ho, D5
Issue Date2006
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/32763
CitationJournal Of Medical Virology, 2006, v. 78 n. 1, p. 1-8 [How to Cite?]
DOI: http://dx.doi.org/10.1002/jmv.20499
AbstractMost of the SARS-CoV-infected patients spontaneously recovered without clinical intervention while a small percentage succumbed to the disease. Here, we characterized temporal changes in N protein-specific and S glycoprotein-specific neutralizing antibody (Nab) responses in infected patients who have either recovered from or succumbed to SARS-CoV infection. Recovered patients were found to have higher and sustainable levels of both N protein-specific and S glycoprotein-specific Nab responses, suggesting that antibody responses likely play an important role in determining the ultimate disease outcome of SARS-CoV-infected patients. © 2005 Wiley-Liss, Inc.
ISSN0146-6615
2011 Impact Factor: 2.82
2011 SCImago Journal Rankings: 0.267
DOIhttp://dx.doi.org/10.1002/jmv.20499
ISI Accession Number IDWOS:000233738800001
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorZhang, L
dc.contributor.authorZhang, F
dc.contributor.authorYu, W
dc.contributor.authorHe, T
dc.contributor.authorYu, J
dc.contributor.authorYi, CE
dc.contributor.authorBa, L
dc.contributor.authorLi, W
dc.contributor.authorFarzan, M
dc.contributor.authorChen, Z
dc.contributor.authorYuen, KY
dc.contributor.authorHo, D
dc.date.accessioned2012-08-08T08:49:52Z
dc.date.available2012-08-08T08:49:52Z
dc.date.issued2006
dc.description.abstractMost of the SARS-CoV-infected patients spontaneously recovered without clinical intervention while a small percentage succumbed to the disease. Here, we characterized temporal changes in N protein-specific and S glycoprotein-specific neutralizing antibody (Nab) responses in infected patients who have either recovered from or succumbed to SARS-CoV infection. Recovered patients were found to have higher and sustainable levels of both N protein-specific and S glycoprotein-specific Nab responses, suggesting that antibody responses likely play an important role in determining the ultimate disease outcome of SARS-CoV-infected patients. © 2005 Wiley-Liss, Inc.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationJournal Of Medical Virology, 2006, v. 78 n. 1, p. 1-8 [How to Cite?]
DOI: http://dx.doi.org/10.1002/jmv.20499
dc.identifier.doihttp://dx.doi.org/10.1002/jmv.20499
dc.identifier.epage8
dc.identifier.isiWOS:000233738800001
dc.identifier.issn0146-6615
2011 Impact Factor: 2.82
2011 SCImago Journal Rankings: 0.267
dc.identifier.issue1
dc.identifier.pmid16299724
dc.identifier.scopuseid_2-s2.0-28944441428
dc.identifier.spage1
dc.identifier.urihttp://hdl.handle.net/10722/157427
dc.identifier.volume78
dc.languageeng
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/32763
dc.publisher.placeUnited States
dc.relation.ispartofJournal of Medical Virology
dc.relation.referencesReferences in Scopus
dc.subject.meshAntibodies, Viral - Blood - Immunology
dc.subject.meshDisease Progression
dc.subject.meshHumans
dc.subject.meshMembrane Glycoproteins - Immunology
dc.subject.meshNeutralization Tests
dc.subject.meshNucleocapsid Proteins - Immunology
dc.subject.meshSars Virus - Immunology
dc.subject.meshSevere Acute Respiratory Syndrome - Immunology - Physiopathology
dc.subject.meshViral Envelope Proteins - Immunology
dc.titleAntibody responses against SARS coronavirus are correlated with disease outcome of infected individuals
dc.typeArticle
Author Affiliations
  1. Harvard Medical School
  2. The University of Hong Kong
  3. Aaron Diamond AIDS Research Center
  4. Chinese Academy of Medical Sciences
  5. Rockefeller University