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Article: Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals
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TitleAntibody responses against SARS coronavirus are correlated with disease outcome of infected individuals
 
AuthorsZhang, L5 4 3
Zhang, F5
Yu, W5
He, T5
Yu, J5
Yi, CE5
Ba, L5
Li, W2
Farzan, M2
Chen, Z5
Yuen, KY1
Ho, D5
 
Issue Date2006
 
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/32763
 
CitationJournal Of Medical Virology, 2006, v. 78 n. 1, p. 1-8 [How to Cite?]
DOI: http://dx.doi.org/10.1002/jmv.20499
 
AbstractMost of the SARS-CoV-infected patients spontaneously recovered without clinical intervention while a small percentage succumbed to the disease. Here, we characterized temporal changes in N protein-specific and S glycoprotein-specific neutralizing antibody (Nab) responses in infected patients who have either recovered from or succumbed to SARS-CoV infection. Recovered patients were found to have higher and sustainable levels of both N protein-specific and S glycoprotein-specific Nab responses, suggesting that antibody responses likely play an important role in determining the ultimate disease outcome of SARS-CoV-infected patients. © 2005 Wiley-Liss, Inc.
 
ISSN0146-6615
2013 Impact Factor: 2.217
 
DOIhttp://dx.doi.org/10.1002/jmv.20499
 
ISI Accession Number IDWOS:000233738800001
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorZhang, L
 
dc.contributor.authorZhang, F
 
dc.contributor.authorYu, W
 
dc.contributor.authorHe, T
 
dc.contributor.authorYu, J
 
dc.contributor.authorYi, CE
 
dc.contributor.authorBa, L
 
dc.contributor.authorLi, W
 
dc.contributor.authorFarzan, M
 
dc.contributor.authorChen, Z
 
dc.contributor.authorYuen, KY
 
dc.contributor.authorHo, D
 
dc.date.accessioned2012-08-08T08:49:52Z
 
dc.date.available2012-08-08T08:49:52Z
 
dc.date.issued2006
 
dc.description.abstractMost of the SARS-CoV-infected patients spontaneously recovered without clinical intervention while a small percentage succumbed to the disease. Here, we characterized temporal changes in N protein-specific and S glycoprotein-specific neutralizing antibody (Nab) responses in infected patients who have either recovered from or succumbed to SARS-CoV infection. Recovered patients were found to have higher and sustainable levels of both N protein-specific and S glycoprotein-specific Nab responses, suggesting that antibody responses likely play an important role in determining the ultimate disease outcome of SARS-CoV-infected patients. © 2005 Wiley-Liss, Inc.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Medical Virology, 2006, v. 78 n. 1, p. 1-8 [How to Cite?]
DOI: http://dx.doi.org/10.1002/jmv.20499
 
dc.identifier.doihttp://dx.doi.org/10.1002/jmv.20499
 
dc.identifier.epage8
 
dc.identifier.isiWOS:000233738800001
 
dc.identifier.issn0146-6615
2013 Impact Factor: 2.217
 
dc.identifier.issue1
 
dc.identifier.pmid16299724
 
dc.identifier.scopuseid_2-s2.0-28944441428
 
dc.identifier.spage1
 
dc.identifier.urihttp://hdl.handle.net/10722/157427
 
dc.identifier.volume78
 
dc.languageeng
 
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/32763
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Medical Virology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAntibodies, Viral - Blood - Immunology
 
dc.subject.meshDisease Progression
 
dc.subject.meshHumans
 
dc.subject.meshMembrane Glycoproteins - Immunology
 
dc.subject.meshNeutralization Tests
 
dc.subject.meshNucleocapsid Proteins - Immunology
 
dc.subject.meshSars Virus - Immunology
 
dc.subject.meshSevere Acute Respiratory Syndrome - Immunology - Physiopathology
 
dc.subject.meshViral Envelope Proteins - Immunology
 
dc.titleAntibody responses against SARS coronavirus are correlated with disease outcome of infected individuals
 
dc.typeArticle
 
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<contributor.author>Yu, J</contributor.author>
<contributor.author>Yi, CE</contributor.author>
<contributor.author>Ba, L</contributor.author>
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Author Affiliations
  1. The University of Hong Kong
  2. Harvard Medical School
  3. Aaron Diamond AIDS Research Center
  4. Chinese Academy of Medical Sciences
  5. Rockefeller University