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Article: Structural biology: Structure of a V3-containing HIV-1 gp120 core

TitleStructural biology: Structure of a V3-containing HIV-1 gp120 core
Authors
Issue Date2005
PublisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.org
Citation
Science, 2005, v. 310 n. 5750, p. 1025-1028 How to Cite?
AbstractThe third variable region (V3) of the HIV-1 gp120 envelope glycoprotein is immunodominant and contains features essential for coreceptor binding. We determined the structure of V3 in the context of an HIV-1 gp120 core complexed to the CD4 receptor and to the X5 antibody at 3.5 angstrom resolution. Binding of gp120 to cell-surface CD4 would position V3 so that its coreceptor-binding tip protrudes 30 angstroms from the core toward the target cell membrane. The extended nature and antibody accessibility of V3 explain its immunodominance. Together, the results provide a structural rationale for the role of V3 in HIV entry and neutralization.
Persistent Identifierhttp://hdl.handle.net/10722/157424
ISSN
2015 Impact Factor: 34.661
2015 SCImago Journal Rankings: 13.217
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHuang, CCen_US
dc.contributor.authorTang, Men_US
dc.contributor.authorZhang, MYen_US
dc.contributor.authorMajeed, Sen_US
dc.contributor.authorMontabana, Een_US
dc.contributor.authorStanfield, RLen_US
dc.contributor.authorDimitrov, DSen_US
dc.contributor.authorKorber, Ben_US
dc.contributor.authorSodroski, Jen_US
dc.contributor.authorWilson, IAen_US
dc.contributor.authorWyatt, Ren_US
dc.contributor.authorKwong, PDen_US
dc.date.accessioned2012-08-08T08:49:51Z-
dc.date.available2012-08-08T08:49:51Z-
dc.date.issued2005en_US
dc.identifier.citationScience, 2005, v. 310 n. 5750, p. 1025-1028en_US
dc.identifier.issn0036-8075en_US
dc.identifier.urihttp://hdl.handle.net/10722/157424-
dc.description.abstractThe third variable region (V3) of the HIV-1 gp120 envelope glycoprotein is immunodominant and contains features essential for coreceptor binding. We determined the structure of V3 in the context of an HIV-1 gp120 core complexed to the CD4 receptor and to the X5 antibody at 3.5 angstrom resolution. Binding of gp120 to cell-surface CD4 would position V3 so that its coreceptor-binding tip protrudes 30 angstroms from the core toward the target cell membrane. The extended nature and antibody accessibility of V3 explain its immunodominance. Together, the results provide a structural rationale for the role of V3 in HIV entry and neutralization.en_US
dc.languageengen_US
dc.publisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.orgen_US
dc.relation.ispartofScienceen_US
dc.titleStructural biology: Structure of a V3-containing HIV-1 gp120 coreen_US
dc.typeArticleen_US
dc.identifier.emailZhang, MY:zhangmy@hku.hken_US
dc.identifier.authorityZhang, MY=rp01409en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1126/science.1118398en_US
dc.identifier.pmid16284180-
dc.identifier.scopuseid_2-s2.0-27744597054en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-27744597054&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume310en_US
dc.identifier.issue5750en_US
dc.identifier.spage1025en_US
dc.identifier.epage1028en_US
dc.identifier.isiWOS:000233343400046-
dc.publisher.placeUnited Statesen_US
dc.identifier.f10001029423-
dc.identifier.scopusauthoridHuang, CC=7406888371en_US
dc.identifier.scopusauthoridTang, M=55205546900en_US
dc.identifier.scopusauthoridZhang, MY=35316639300en_US
dc.identifier.scopusauthoridMajeed, S=7006490845en_US
dc.identifier.scopusauthoridMontabana, E=9237658800en_US
dc.identifier.scopusauthoridStanfield, RL=35513093100en_US
dc.identifier.scopusauthoridDimitrov, DS=7202564539en_US
dc.identifier.scopusauthoridKorber, B=19335057200en_US
dc.identifier.scopusauthoridSodroski, J=7102286559en_US
dc.identifier.scopusauthoridWilson, IA=7401743864en_US
dc.identifier.scopusauthoridWyatt, R=7402848241en_US
dc.identifier.scopusauthoridKwong, PD=7006992407en_US
dc.identifier.citeulike436475-

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