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Article: RANTES gene single nucleotide polymorphisms and expression in patients with chronic hepatitis B virus infection

TitleRANTES gene single nucleotide polymorphisms and expression in patients with chronic hepatitis B virus infection
Authors
Issue Date2005
PublisherZhonghua Yixuehui. The Journal's web site is located at http://www.cmj.org/
Citation
Chinese Medical Journal, 2005, v. 118 n. 11, p. 909-914 How to Cite?
AbstractBackground: Regulated on activation, normal T-cell expressed and secreted (RANTES) plays a critical role in T-lymphocyte activation and proliferation. The process is involved in both acute and chronic phases of inflammation. The present study was to ascertain the possible correlations between chronic hepatitis B virus (HBV) infection and the RANTES gene polymorphisms and their expression. Methods: The study included 130 HBV negative healthy donors and 152 patients with chronic hepatitis B (CHB) virus infection. The polymerase chain reaction (PCR) and restriction fragment length polymorphisms (RFLPs) were used to detect RANTES gene single nucleotide polymorphisms (SNPs). RANTES levels in the platelet depleted plasma were detected by enzyme linked immunosorbent assay (ELISA). Results: RANTES alleles -403G, -28C and In1. 1T were the predominant alleles in the subjects studied. No significant correlation was found between CHB infection and the RANTES alleles, while a significant correlation was found between CHB infection and increased RANTES expression in platelet depleted plasma (P <0.05). Conclusions: SNPs in RANTES gene do not affect chronic HBV infection or the outcome of interferon-α treatment in patients positive for HBV "e" antigen (HBeAg + ). However, patients with CHB infection express the higher levels of plasma RANTES, which is thus associated with CHB infection.
Persistent Identifierhttp://hdl.handle.net/10722/157410
ISSN
2015 Impact Factor: 0.957
2015 SCImago Journal Rankings: 0.428
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDuan, ZPen_US
dc.contributor.authorZhao, XYen_US
dc.contributor.authorHuang, DZen_US
dc.contributor.authorHe, LXen_US
dc.contributor.authorChen, Yen_US
dc.contributor.authorZhao, CHen_US
dc.contributor.authorZheng, Ben_US
dc.date.accessioned2012-08-08T08:49:43Z-
dc.date.available2012-08-08T08:49:43Z-
dc.date.issued2005en_US
dc.identifier.citationChinese Medical Journal, 2005, v. 118 n. 11, p. 909-914en_US
dc.identifier.issn0366-6999en_US
dc.identifier.urihttp://hdl.handle.net/10722/157410-
dc.description.abstractBackground: Regulated on activation, normal T-cell expressed and secreted (RANTES) plays a critical role in T-lymphocyte activation and proliferation. The process is involved in both acute and chronic phases of inflammation. The present study was to ascertain the possible correlations between chronic hepatitis B virus (HBV) infection and the RANTES gene polymorphisms and their expression. Methods: The study included 130 HBV negative healthy donors and 152 patients with chronic hepatitis B (CHB) virus infection. The polymerase chain reaction (PCR) and restriction fragment length polymorphisms (RFLPs) were used to detect RANTES gene single nucleotide polymorphisms (SNPs). RANTES levels in the platelet depleted plasma were detected by enzyme linked immunosorbent assay (ELISA). Results: RANTES alleles -403G, -28C and In1. 1T were the predominant alleles in the subjects studied. No significant correlation was found between CHB infection and the RANTES alleles, while a significant correlation was found between CHB infection and increased RANTES expression in platelet depleted plasma (P <0.05). Conclusions: SNPs in RANTES gene do not affect chronic HBV infection or the outcome of interferon-α treatment in patients positive for HBV "e" antigen (HBeAg + ). However, patients with CHB infection express the higher levels of plasma RANTES, which is thus associated with CHB infection.en_US
dc.languageengen_US
dc.publisherZhonghua Yixuehui. The Journal's web site is located at http://www.cmj.org/en_US
dc.relation.ispartofChinese Medical Journalen_US
dc.subject.meshAllelesen_US
dc.subject.meshChemokine Ccl5 - Geneticsen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHepatitis B, Chronic - Drug Therapy - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshInterferon-Alpha - Therapeutic Useen_US
dc.subject.meshPolymorphism, Single Nucleotideen_US
dc.titleRANTES gene single nucleotide polymorphisms and expression in patients with chronic hepatitis B virus infectionen_US
dc.typeArticleen_US
dc.identifier.emailZheng, B: bzheng@hkucc.hku.hken_US
dc.identifier.authorityZheng, BJ=rp00353en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.pmid15978191-
dc.identifier.scopuseid_2-s2.0-20944442464en_US
dc.identifier.hkuros99119-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-20944442464&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume118en_US
dc.identifier.issue11en_US
dc.identifier.spage909en_US
dc.identifier.epage914en_US
dc.identifier.isiWOS:000229823000005-
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridDuan, ZP=7101936556en_US
dc.identifier.scopusauthoridZhao, XY=7407577215en_US
dc.identifier.scopusauthoridHuang, DZ=7403891319en_US
dc.identifier.scopusauthoridHe, LX=7403374259en_US
dc.identifier.scopusauthoridChen, Y=25927793500en_US
dc.identifier.scopusauthoridZhao, CH=7403563984en_US
dc.identifier.scopusauthoridZheng, BJ=7201780588en_US
dc.customcontrol.immutablesml 130529-

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