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- Scopus: eid_2-s2.0-17144382020
- PMID: 15844623
- WOS: WOS:000228420800009
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Article: Human monoclonal antibodies to the S glycoprotein and related proteins as potential therapeutics for SARS
Title | Human monoclonal antibodies to the S glycoprotein and related proteins as potential therapeutics for SARS |
---|---|
Authors | |
Keywords | Antibodies Prophylaxis S glycoprotein S protein SARS Therapy Treatment |
Issue Date | 2005 |
Publisher | Current Drugs Ltd. The Journal's web site is located at http://www.biomedcentral.com/1464-8431 |
Citation | Current Opinion In Molecular Therapeutics, 2005, v. 7 n. 2, p. 151-156 How to Cite? |
Abstract | Polyclonal antibodies have a century-old history of being effective against some viruses and, recently, monoclonal antibodies (mAbs) have also shown some clinical success. Human mAbs to the severe acute respiratory syndrome (SARS) coronavirus spike glycoprotein have been developed by several research groups at an amazing pace. These antibodies potently neutralize infectious virus in tissue cultures and animal models, and, alone or in combination with vaccines and other drugs, may have potential for the prevention and treatment of SARS. © The Thomson Corporation. |
Persistent Identifier | http://hdl.handle.net/10722/157402 |
ISSN | 2012 Impact Factor: 3.416 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhang, MY | en_US |
dc.contributor.author | Choudhry, V | en_US |
dc.contributor.author | Xiao, X | en_US |
dc.contributor.author | Dimitrov, DS | en_US |
dc.date.accessioned | 2012-08-08T08:49:40Z | - |
dc.date.available | 2012-08-08T08:49:40Z | - |
dc.date.issued | 2005 | en_US |
dc.identifier.citation | Current Opinion In Molecular Therapeutics, 2005, v. 7 n. 2, p. 151-156 | en_US |
dc.identifier.issn | 1464-8431 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/157402 | - |
dc.description.abstract | Polyclonal antibodies have a century-old history of being effective against some viruses and, recently, monoclonal antibodies (mAbs) have also shown some clinical success. Human mAbs to the severe acute respiratory syndrome (SARS) coronavirus spike glycoprotein have been developed by several research groups at an amazing pace. These antibodies potently neutralize infectious virus in tissue cultures and animal models, and, alone or in combination with vaccines and other drugs, may have potential for the prevention and treatment of SARS. © The Thomson Corporation. | en_US |
dc.language | eng | en_US |
dc.publisher | Current Drugs Ltd. The Journal's web site is located at http://www.biomedcentral.com/1464-8431 | en_US |
dc.relation.ispartof | Current Opinion in Molecular Therapeutics | en_US |
dc.subject | Antibodies | - |
dc.subject | Prophylaxis | - |
dc.subject | S glycoprotein | - |
dc.subject | S protein | - |
dc.subject | SARS | - |
dc.subject | Therapy | - |
dc.subject | Treatment | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Antibodies, Monoclonal - Immunology - Therapeutic Use | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Immunoglobulins - Genetics - Immunology | en_US |
dc.subject.mesh | Mice | en_US |
dc.subject.mesh | Mice, Transgenic | en_US |
dc.subject.mesh | Sars Virus - Immunology | en_US |
dc.subject.mesh | Severe Acute Respiratory Syndrome - Drug Therapy - Immunology | en_US |
dc.subject.mesh | Viral Proteins - Immunology | en_US |
dc.title | Human monoclonal antibodies to the S glycoprotein and related proteins as potential therapeutics for SARS | en_US |
dc.type | Article | en_US |
dc.identifier.email | Zhang, MY:zhangmy@hku.hk | en_US |
dc.identifier.authority | Zhang, MY=rp01409 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 15844623 | - |
dc.identifier.scopus | eid_2-s2.0-17144382020 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-17144382020&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 7 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 151 | en_US |
dc.identifier.epage | 156 | en_US |
dc.identifier.isi | WOS:000228420800009 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Zhang, MY=35316639300 | en_US |
dc.identifier.scopusauthorid | Choudhry, V=8530897500 | en_US |
dc.identifier.scopusauthorid | Xiao, X=7402168892 | en_US |
dc.identifier.scopusauthorid | Dimitrov, DS=7202564539 | en_US |
dc.identifier.issnl | 1464-8431 | - |