File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: HIV-1 subtype B′ dictates the AIDS epidemic among paid blood donors in the Henan and Hubei provinces of China

TitleHIV-1 subtype B′ dictates the AIDS epidemic among paid blood donors in the Henan and Hubei provinces of China
Authors
Issue Date2003
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.AIDSonline.com
Citation
Aids, 2003, v. 17 n. 17, p. 2515-2520 How to Cite?
AbstractObjective: To investigate the genetic background of HIV-1 strains among infected paid blood donors (PBD) in the Henan and Hubei provinces of China. Methods: The polymerase chain reaction was used to amplify HIV-1 gag p17 fragments and some 5′-half or full-length viral genomes from peripheral blood mononuclear cells. The HIV-1 sequences obtained were analysed using phylogenetic and recombinant approaches. Results: Among the total of 62 samples studied, 59 (95.2%) came from PBD. Of those 59 PBD, 45 were collected from 14 different geographical locations in Henan, whereas the remaining 14 were from five locations in Hubei. A total of 62 HIV-1 gag p17 fragments, three 5′-half and one full HIV-1 genome sequences were obtained. Phylogenetic analysis of these sequences suggests that PBD from Henan and Hubei, despite being geographically distant, harbored a group of genetically closely related HIV-1 B′ strains. No recombinant forms have been detected in this cohort. Conclusion: Our data indicate that the AIDS epidemic among PBD in Henan and Hubei is caused largely by HIV-1 subtype B′, which contrasts greatly with the CB′ recombinant strains CRF-07 and CRF-08 currently dominating among the drug abusers in other regions of China. Our report has revealed the first complete genome background of the most dominant circulating HIV-1 strain in Henan and Hubei, which is essential for the design and development of an effective AIDS vaccine for the region. © 2003 Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/157400
ISSN
2015 Impact Factor: 4.407
2015 SCImago Journal Rankings: 3.112
References

 

DC FieldValueLanguage
dc.contributor.authorSu, Ben_US
dc.contributor.authorLiu, Len_US
dc.contributor.authorWang, Fen_US
dc.contributor.authorGui, Xen_US
dc.contributor.authorZhao, Men_US
dc.contributor.authorTien, Pen_US
dc.contributor.authorZhang, Len_US
dc.contributor.authorChen, Zen_US
dc.date.accessioned2012-08-08T08:49:38Z-
dc.date.available2012-08-08T08:49:38Z-
dc.date.issued2003en_US
dc.identifier.citationAids, 2003, v. 17 n. 17, p. 2515-2520en_US
dc.identifier.issn0269-9370en_US
dc.identifier.urihttp://hdl.handle.net/10722/157400-
dc.description.abstractObjective: To investigate the genetic background of HIV-1 strains among infected paid blood donors (PBD) in the Henan and Hubei provinces of China. Methods: The polymerase chain reaction was used to amplify HIV-1 gag p17 fragments and some 5′-half or full-length viral genomes from peripheral blood mononuclear cells. The HIV-1 sequences obtained were analysed using phylogenetic and recombinant approaches. Results: Among the total of 62 samples studied, 59 (95.2%) came from PBD. Of those 59 PBD, 45 were collected from 14 different geographical locations in Henan, whereas the remaining 14 were from five locations in Hubei. A total of 62 HIV-1 gag p17 fragments, three 5′-half and one full HIV-1 genome sequences were obtained. Phylogenetic analysis of these sequences suggests that PBD from Henan and Hubei, despite being geographically distant, harbored a group of genetically closely related HIV-1 B′ strains. No recombinant forms have been detected in this cohort. Conclusion: Our data indicate that the AIDS epidemic among PBD in Henan and Hubei is caused largely by HIV-1 subtype B′, which contrasts greatly with the CB′ recombinant strains CRF-07 and CRF-08 currently dominating among the drug abusers in other regions of China. Our report has revealed the first complete genome background of the most dominant circulating HIV-1 strain in Henan and Hubei, which is essential for the design and development of an effective AIDS vaccine for the region. © 2003 Lippincott Williams & Wilkins.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.AIDSonline.comen_US
dc.relation.ispartofAIDSen_US
dc.subject.meshAcquired Immunodeficiency Syndrome - Epidemiology - Geneticsen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshBlood Donorsen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshChina - Epidemiologyen_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshDisease Outbreaksen_US
dc.subject.meshGenes, Gagen_US
dc.subject.meshGenome, Viralen_US
dc.subject.meshHiv-1 - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPhylogenyen_US
dc.subject.meshReassortant Viruses - Geneticsen_US
dc.titleHIV-1 subtype B′ dictates the AIDS epidemic among paid blood donors in the Henan and Hubei provinces of Chinaen_US
dc.typeArticleen_US
dc.identifier.emailChen, Z:zchenai@hkucc.hku.hken_US
dc.identifier.authorityChen, Z=rp00243en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/00002030-200311210-00015en_US
dc.identifier.pmid14600524-
dc.identifier.scopuseid_2-s2.0-1642376008en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1642376008&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume17en_US
dc.identifier.issue17en_US
dc.identifier.spage2515en_US
dc.identifier.epage2520en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridSu, B=55041064400en_US
dc.identifier.scopusauthoridLiu, L=36068379000en_US
dc.identifier.scopusauthoridWang, F=7501310552en_US
dc.identifier.scopusauthoridGui, X=7006336209en_US
dc.identifier.scopusauthoridZhao, M=21744028000en_US
dc.identifier.scopusauthoridTien, P=7006421622en_US
dc.identifier.scopusauthoridZhang, L=8783285300en_US
dc.identifier.scopusauthoridChen, Z=35271180800en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats