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Article: HIV-1 encoded candidate micro-RNAs and their cellular targets

TitleHIV-1 encoded candidate micro-RNAs and their cellular targets
Authors
Issue Date2004
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.retrovirology.com/home/
Citation
Retrovirology, 2004, v. 1 How to Cite?
AbstractMicroRNAs (miRNAs) are small RNAs of 21-25 nucleotides that specifically regulate cellular gene expression at the post-transcriptional level. miRNAs are derived from the maturation by cellular RNases III of imperfect stem loop structures of ∼70 nucleotides. Evidence for hundreds of miRNAs and their corresponding targets has been reported in the literature for plants, insects, invertebrate animals, and mammals. While not all of these miRNA/target pairs have been functionally verified, some clearly serve roles in regulating normal development and physiology. Recently, it has been queried whether the genome of human viruses like their cellular counterpart also encode miRNA. To date, there has been only one report pertaining to this question. The Epstein-Barr virus (EBV) has been shown to encode five miRNAs. Here, we extend the analysis of miRNA-encoding potential to the human immunodeficiency virus (HIV). Using computer-directed analyses, we found that HIV putatively encodes five candidate pre-miRNAs. We then matched deduced mature miRNA sequences from these 5 pre-miRNAs against a database of 3′ untranslated sequences (UTR) from the human genome. These searches revealed a large number of cellular transcripts that could potentially be targeted by these viral miRNA (vmiRNA) sequences. We propose that HIV has evolved to use vmiRNAs as a means to regulate cellular milieu for its benefit. © 2004 Bennasser et al; licensee BioMed Central Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/157393
ISSN
2015 Impact Factor: 3.989
2015 SCImago Journal Rankings: 2.506
References

 

DC FieldValueLanguage
dc.contributor.authorBennasser, Yen_US
dc.contributor.authorLe, SYen_US
dc.contributor.authorYeung, MLen_US
dc.contributor.authorJeang, KTen_US
dc.date.accessioned2012-08-08T08:49:36Z-
dc.date.available2012-08-08T08:49:36Z-
dc.date.issued2004en_US
dc.identifier.citationRetrovirology, 2004, v. 1en_US
dc.identifier.issn1742-4690en_US
dc.identifier.urihttp://hdl.handle.net/10722/157393-
dc.description.abstractMicroRNAs (miRNAs) are small RNAs of 21-25 nucleotides that specifically regulate cellular gene expression at the post-transcriptional level. miRNAs are derived from the maturation by cellular RNases III of imperfect stem loop structures of ∼70 nucleotides. Evidence for hundreds of miRNAs and their corresponding targets has been reported in the literature for plants, insects, invertebrate animals, and mammals. While not all of these miRNA/target pairs have been functionally verified, some clearly serve roles in regulating normal development and physiology. Recently, it has been queried whether the genome of human viruses like their cellular counterpart also encode miRNA. To date, there has been only one report pertaining to this question. The Epstein-Barr virus (EBV) has been shown to encode five miRNAs. Here, we extend the analysis of miRNA-encoding potential to the human immunodeficiency virus (HIV). Using computer-directed analyses, we found that HIV putatively encodes five candidate pre-miRNAs. We then matched deduced mature miRNA sequences from these 5 pre-miRNAs against a database of 3′ untranslated sequences (UTR) from the human genome. These searches revealed a large number of cellular transcripts that could potentially be targeted by these viral miRNA (vmiRNA) sequences. We propose that HIV has evolved to use vmiRNAs as a means to regulate cellular milieu for its benefit. © 2004 Bennasser et al; licensee BioMed Central Ltd.en_US
dc.languageengen_US
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.retrovirology.com/home/en_US
dc.relation.ispartofRetrovirologyen_US
dc.titleHIV-1 encoded candidate micro-RNAs and their cellular targetsen_US
dc.typeArticleen_US
dc.identifier.emailYeung, ML:pmlyeung@hku.hken_US
dc.identifier.authorityYeung, ML=rp01402en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1186/1742-4690-1-43en_US
dc.identifier.scopuseid_2-s2.0-14344260087en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-14344260087&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume1en_US
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridBennasser, Y=8335747500en_US
dc.identifier.scopusauthoridLe, SY=7006184376en_US
dc.identifier.scopusauthoridYeung, ML=8350940900en_US
dc.identifier.scopusauthoridJeang, KT=7004824803en_US

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