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Article: Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120

TitleStructural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120
Authors
Issue Date2004
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
Citation
Proceedings Of The National Academy Of Sciences Of The United States Of America, 2004, v. 101 n. 9, p. 2706-2711 How to Cite?
AbstractThe conserved surface of the HIV-1 gp120 envelope glycoprotein that binds to the HIV-1 coreceptor is protected from humoral recognition by multiple layers of camouflage. Here we present sequence and genomic analyses for 12 antibodies that pierce these defenses and determine the crystal structures of 5. The data reveal mechanisms and atomic-level details for three unusual immune features: posttranslational mimicry of coreceptor by tyrosine sulfation of antibody, an alternative molecular mechanism controlling such sulfation, and highly selective VH-gene usage. When confronted by extraordinary viral defenses, the immune system unveils novel adaptive capabilities, with tyrosine sulfation enhancing the vocabulary of antigen recognition.
Persistent Identifierhttp://hdl.handle.net/10722/157390
ISSN
2015 Impact Factor: 9.423
2015 SCImago Journal Rankings: 6.883
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHuang, CCen_US
dc.contributor.authorVenturi, Men_US
dc.contributor.authorMajeed, Sen_US
dc.contributor.authorMoore, MJen_US
dc.contributor.authorPhogat, Sen_US
dc.contributor.authorZhang, MYen_US
dc.contributor.authorDimitrov, DSen_US
dc.contributor.authorHendrickson, WAen_US
dc.contributor.authorRobinson, Jen_US
dc.contributor.authorSodroski, Jen_US
dc.contributor.authorWyatt, Ren_US
dc.contributor.authorChoe, Hen_US
dc.contributor.authorFarzan, Men_US
dc.contributor.authorKwong, PDen_US
dc.date.accessioned2012-08-08T08:49:35Z-
dc.date.available2012-08-08T08:49:35Z-
dc.date.issued2004en_US
dc.identifier.citationProceedings Of The National Academy Of Sciences Of The United States Of America, 2004, v. 101 n. 9, p. 2706-2711en_US
dc.identifier.issn0027-8424en_US
dc.identifier.urihttp://hdl.handle.net/10722/157390-
dc.description.abstractThe conserved surface of the HIV-1 gp120 envelope glycoprotein that binds to the HIV-1 coreceptor is protected from humoral recognition by multiple layers of camouflage. Here we present sequence and genomic analyses for 12 antibodies that pierce these defenses and determine the crystal structures of 5. The data reveal mechanisms and atomic-level details for three unusual immune features: posttranslational mimicry of coreceptor by tyrosine sulfation of antibody, an alternative molecular mechanism controlling such sulfation, and highly selective VH-gene usage. When confronted by extraordinary viral defenses, the immune system unveils novel adaptive capabilities, with tyrosine sulfation enhancing the vocabulary of antigen recognition.en_US
dc.languageengen_US
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.orgen_US
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of Americaen_US
dc.subject.meshAcquired Immunodeficiency Syndrome - Immunologyen_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshAntibody Formationen_US
dc.subject.meshAntigens, Cd4 - Immunologyen_US
dc.subject.meshCrystallography, X-Rayen_US
dc.subject.meshGenes, Immunoglobulinen_US
dc.subject.meshHiv Envelope Protein Gp120 - Immunologyen_US
dc.subject.meshHiv Infections - Immunologyen_US
dc.subject.meshHiv-1 - Immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulin Fab Fragments - Chemistryen_US
dc.subject.meshImmunoglobulin Heavy Chains - Geneticsen_US
dc.subject.meshImmunoglobulin Joining Region - Chemistry - Geneticsen_US
dc.subject.meshImmunoglobulin Variable Region - Chemistry - Geneticsen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshSulfates - Metabolismen_US
dc.subject.meshTyrosine - Analogs & Derivatives - Metabolismen_US
dc.titleStructural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120en_US
dc.typeArticleen_US
dc.identifier.emailZhang, MY:zhangmy@hku.hken_US
dc.identifier.authorityZhang, MY=rp01409en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1073/pnas.0308527100en_US
dc.identifier.pmid14981267-
dc.identifier.scopuseid_2-s2.0-12144290520en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-12144290520&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume101en_US
dc.identifier.issue9en_US
dc.identifier.spage2706en_US
dc.identifier.epage2711en_US
dc.identifier.isiWOS:000220065300014-
dc.publisher.placeUnited Statesen_US
dc.identifier.f10001019175-
dc.identifier.scopusauthoridHuang, CC=7406888371en_US
dc.identifier.scopusauthoridVenturi, M=7006559806en_US
dc.identifier.scopusauthoridMajeed, S=7006490845en_US
dc.identifier.scopusauthoridMoore, MJ=7404469988en_US
dc.identifier.scopusauthoridPhogat, S=6602665528en_US
dc.identifier.scopusauthoridZhang, MY=35316639300en_US
dc.identifier.scopusauthoridDimitrov, DS=7202564539en_US
dc.identifier.scopusauthoridHendrickson, WA=7102832519en_US
dc.identifier.scopusauthoridRobinson, J=35418328400en_US
dc.identifier.scopusauthoridSodroski, J=7102286559en_US
dc.identifier.scopusauthoridWyatt, R=7402848241en_US
dc.identifier.scopusauthoridChoe, H=7103055410en_US
dc.identifier.scopusauthoridFarzan, M=7003535041en_US
dc.identifier.scopusauthoridKwong, PD=7006992407en_US
dc.identifier.citeulike5172806-

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