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Article: Identification of a novel CD4i human monoclonal antibody Fab that neutralizes HIV-1 primary isolates from different clades

TitleIdentification of a novel CD4i human monoclonal antibody Fab that neutralizes HIV-1 primary isolates from different clades
Authors
Issue Date2004
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/antiviral
Citation
Antiviral Research, 2004, v. 61 n. 3, p. 161-164 How to Cite?
AbstractA new human monoclonal antibody (hmAb), designated m16, was selected by sequential antigen panning (SAP) of a human phage display library against recombinant soluble HIV-1 envelope glycoproteins (Envs) (gp140s) and their complexes with soluble CD4. It bound with high (nM) affinity to gp120 and gp140; the binding was further enhanced by interactions of the Envs with CD4. m16 inhibited cell fusion mediated by the Envs of 9 HIV-1 isolates from clades A, B, E and G with potency on average comparable to that of the broadly neutralizing human monoclonal antibody Fab X5. The identification of a new hmAb with broad neutralizing activity that exhibits differential inhibitory profile suggests a potential for its use as a component of anti-HIV-1 treatments.
Persistent Identifierhttp://hdl.handle.net/10722/157381
ISSN
2014 Impact Factor: 3.938
2013 SCImago Journal Rankings: 1.512
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, MYen_US
dc.contributor.authorShu, Yen_US
dc.contributor.authorSidorov, Ien_US
dc.contributor.authorDimitrov, DSen_US
dc.date.accessioned2012-08-08T08:49:29Z-
dc.date.available2012-08-08T08:49:29Z-
dc.date.issued2004en_US
dc.identifier.citationAntiviral Research, 2004, v. 61 n. 3, p. 161-164en_US
dc.identifier.issn0166-3542en_US
dc.identifier.urihttp://hdl.handle.net/10722/157381-
dc.description.abstractA new human monoclonal antibody (hmAb), designated m16, was selected by sequential antigen panning (SAP) of a human phage display library against recombinant soluble HIV-1 envelope glycoproteins (Envs) (gp140s) and their complexes with soluble CD4. It bound with high (nM) affinity to gp120 and gp140; the binding was further enhanced by interactions of the Envs with CD4. m16 inhibited cell fusion mediated by the Envs of 9 HIV-1 isolates from clades A, B, E and G with potency on average comparable to that of the broadly neutralizing human monoclonal antibody Fab X5. The identification of a new hmAb with broad neutralizing activity that exhibits differential inhibitory profile suggests a potential for its use as a component of anti-HIV-1 treatments.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/antiviralen_US
dc.relation.ispartofAntiviral Researchen_US
dc.subject.meshAntibodies, Monoclonal - Immunologyen_US
dc.subject.meshAntibody Affinityen_US
dc.subject.meshAntigens, Cd4 - Immunologyen_US
dc.subject.meshCell Fusionen_US
dc.subject.meshGene Products, Env - Immunologyen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHiv Antibodies - Immunologyen_US
dc.subject.meshHiv Antigens - Immunologyen_US
dc.subject.meshHiv Envelope Protein Gp120 - Immunologyen_US
dc.subject.meshHiv-1 - Genetics - Immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulin Fab Fragments - Immunologyen_US
dc.subject.meshNeutralization Testsen_US
dc.subject.meshPeptide Libraryen_US
dc.subject.meshProtein Bindingen_US
dc.subject.meshRecombinant Proteins - Immunologyen_US
dc.subject.meshEnv Gene Products, Human Immunodeficiency Virusen_US
dc.titleIdentification of a novel CD4i human monoclonal antibody Fab that neutralizes HIV-1 primary isolates from different cladesen_US
dc.typeArticleen_US
dc.identifier.emailZhang, MY:zhangmy@hku.hken_US
dc.identifier.authorityZhang, MY=rp01409en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.antiviral.2003.09.009en_US
dc.identifier.pmid15168796en_US
dc.identifier.scopuseid_2-s2.0-0842311270en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0842311270&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume61en_US
dc.identifier.issue3en_US
dc.identifier.spage161en_US
dc.identifier.epage164en_US
dc.identifier.isiWOS:000189131000003-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridZhang, MY=35316639300en_US
dc.identifier.scopusauthoridShu, Y=7103239429en_US
dc.identifier.scopusauthoridSidorov, I=7005186545en_US
dc.identifier.scopusauthoridDimitrov, DS=7202564539en_US

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