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Article: Impact of donor arm skin disinfection on the bacterial contamination rate of platelet concentrates

TitleImpact of donor arm skin disinfection on the bacterial contamination rate of platelet concentrates
Authors
Issue Date2002
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/VOX
Citation
Vox Sanguinis, 2002, v. 83 n. 3, p. 204-208 How to Cite?
AbstractBackground and Objectives: Despite improved methods for detecting bacterial contamination of blood products, bacterial sepsis remains a significant risk in blood transfusion. This study was undertaken to investigate whether adopting a different skin disinfection protocol could reduce the rate of bacterial contamination of platelet concentrates. Materials and Methods: Two skin disinfection protocols were consecutively used in the routine blood collection setting during two 10-month periods: 0.5% cetrimide/0.05% chlorhexidine solution followed by 70% isopropyl alcohol (first 10-month time-period); and 10% povidone-iodine followed by 70% isopropyl alcohol (second 10-month time-period). The rates of bacterial contamination of platelet concentrates were monitored by using a surveillance programme described previously. Results: The overall bacterial contamination rate in the first time-period was 0.072%. After introduction of the povidone-iodine and isopropyl alcohol protocol, the bacterial contamination rate decreased to 0.042% (relative risk reduction: -0.42; 95% confidence interval, -0.12 to -0.61, P = 0.009). There were no differences in the types of micro-organisms identified (P = 0.7). Conclusions: Skin disinfection by povidone-iodine and isopropyl alcohol is more effective than that by cetrimide/chorhexidine and isopropyl alcohol in reducing venepuncture-associated contamination of platelet concentrates by skin flora. Our data indicate that the disinfection protocol should be used on a routine basis and such implementation should translate into a significant improvement in blood safety to patients receiving platelet transfusion.
Persistent Identifierhttp://hdl.handle.net/10722/157359
ISSN
2015 Impact Factor: 2.628
2015 SCImago Journal Rankings: 1.108
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, CKen_US
dc.contributor.authorHo, PLen_US
dc.contributor.authorChan, NKen_US
dc.contributor.authorMak, Aen_US
dc.contributor.authorHong, Jen_US
dc.contributor.authorLin, CKen_US
dc.date.accessioned2012-08-08T08:49:19Z-
dc.date.available2012-08-08T08:49:19Z-
dc.date.issued2002en_US
dc.identifier.citationVox Sanguinis, 2002, v. 83 n. 3, p. 204-208en_US
dc.identifier.issn0042-9007en_US
dc.identifier.urihttp://hdl.handle.net/10722/157359-
dc.description.abstractBackground and Objectives: Despite improved methods for detecting bacterial contamination of blood products, bacterial sepsis remains a significant risk in blood transfusion. This study was undertaken to investigate whether adopting a different skin disinfection protocol could reduce the rate of bacterial contamination of platelet concentrates. Materials and Methods: Two skin disinfection protocols were consecutively used in the routine blood collection setting during two 10-month periods: 0.5% cetrimide/0.05% chlorhexidine solution followed by 70% isopropyl alcohol (first 10-month time-period); and 10% povidone-iodine followed by 70% isopropyl alcohol (second 10-month time-period). The rates of bacterial contamination of platelet concentrates were monitored by using a surveillance programme described previously. Results: The overall bacterial contamination rate in the first time-period was 0.072%. After introduction of the povidone-iodine and isopropyl alcohol protocol, the bacterial contamination rate decreased to 0.042% (relative risk reduction: -0.42; 95% confidence interval, -0.12 to -0.61, P = 0.009). There were no differences in the types of micro-organisms identified (P = 0.7). Conclusions: Skin disinfection by povidone-iodine and isopropyl alcohol is more effective than that by cetrimide/chorhexidine and isopropyl alcohol in reducing venepuncture-associated contamination of platelet concentrates by skin flora. Our data indicate that the disinfection protocol should be used on a routine basis and such implementation should translate into a significant improvement in blood safety to patients receiving platelet transfusion.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/VOXen_US
dc.relation.ispartofVox Sanguinisen_US
dc.subject.mesh2-Propanol - Pharmacologyen_US
dc.subject.meshArmen_US
dc.subject.meshBacterial Infections - Prevention & Control - Transmissionen_US
dc.subject.meshBlood Donorsen_US
dc.subject.meshBlood Platelets - Microbiologyen_US
dc.subject.meshBlood Specimen Collectionen_US
dc.subject.meshCetrimonium Compounds - Pharmacologyen_US
dc.subject.meshDisinfectants - Pharmacologyen_US
dc.subject.meshDisinfection - Methodsen_US
dc.subject.meshHumansen_US
dc.subject.meshPlatelet Transfusion - Adverse Effectsen_US
dc.subject.meshPovidone-Iodine - Pharmacologyen_US
dc.subject.meshSkin - Microbiologyen_US
dc.titleImpact of donor arm skin disinfection on the bacterial contamination rate of platelet concentratesen_US
dc.typeArticleen_US
dc.identifier.emailHo, PL:plho@hkucc.hku.hken_US
dc.identifier.authorityHo, PL=rp00406en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1046/j.1423-0410.2002.00219.xen_US
dc.identifier.pmid12366760-
dc.identifier.scopuseid_2-s2.0-0038052936en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0038052936&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume83en_US
dc.identifier.issue3en_US
dc.identifier.spage204en_US
dc.identifier.epage208en_US
dc.identifier.isiWOS:000178478200002-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLee, CK=7410141588en_US
dc.identifier.scopusauthoridHo, PL=7402211363en_US
dc.identifier.scopusauthoridChan, NK=7101677541en_US
dc.identifier.scopusauthoridMak, A=7103123343en_US
dc.identifier.scopusauthoridHong, J=7404118670en_US
dc.identifier.scopusauthoridLin, CK=15034856400en_US

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