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Article: Assessment of nasopharyngeal carcinoma risk by EB virus antibody profile

TitleAssessment of nasopharyngeal carcinoma risk by EB virus antibody profile
Authors
Issue Date2002
Citation
Zhonghua Zhong Liu Za Zhi [Chinese Journal Of Oncology], 2002, v. 24 n. 6, p. 561-563 How to Cite?
AbstractOBJECTIVE: To evaluate the risk of nasopharyngeal carcinoma (NPC) through EB virus antibody profile by enzyme linked immunosorbent assay (ELISA). METHODS: EBNA 1/IgA, EBNA 1/IgG and zta/IgG by ELISA and VCA/IgA by immmunoenzymatic method were detected in 121 NPC patients and 332 healthy subjects (HS) in the Pearl river estuary. RESULTS: The sensitivity rates were 85%, 83% and 79% for EBNA 1/IgA, EBNA 1/IgG and zta/IgG, all three of which if combined was the highest 92%. The specificity rates were 86%, 86% and 80% for EBNA 1/IgA, EBNA 1/IgG and zta/IgG, all three of which if combined was also the highest 93%. According to the level of odds ratio, nasopharyngeal carcinoma risk could be divided into 3 groups: low, moderate and high-risk groups. 93% of HS had low risk of NPC with the odds ratio 0.0 to 0.3. 0.4% of HS had high risk of NPC with the odds ratio of 137.9%. CONCLUSION: ELISA is more objective than the traditional immunoenzymatic method in the detection and diagnosis of NPC. The combination of EBNA 1/IgA, EBNA 1/IgG and zta/IgG is able to evaluate the risk of NPC.
Persistent Identifierhttp://hdl.handle.net/10722/157358
ISSN
2015 SCImago Journal Rankings: 0.190

 

DC FieldValueLanguage
dc.contributor.authorCheng, Wen_US
dc.contributor.authorChen, Gen_US
dc.contributor.authorChen, Hen_US
dc.contributor.authorLuo, Ren_US
dc.contributor.authorWu, Zen_US
dc.contributor.authorLu, Yen_US
dc.contributor.authorZheng, Ben_US
dc.contributor.authorJi, Men_US
dc.contributor.authorLiang, Jen_US
dc.contributor.authorCen, Xen_US
dc.contributor.authorWang, Den_US
dc.contributor.authorZong, Yen_US
dc.contributor.authorWu, Wen_US
dc.date.accessioned2012-08-08T08:49:18Z-
dc.date.available2012-08-08T08:49:18Z-
dc.date.issued2002en_US
dc.identifier.citationZhonghua Zhong Liu Za Zhi [Chinese Journal Of Oncology], 2002, v. 24 n. 6, p. 561-563en_US
dc.identifier.issn0253-3766en_US
dc.identifier.urihttp://hdl.handle.net/10722/157358-
dc.description.abstractOBJECTIVE: To evaluate the risk of nasopharyngeal carcinoma (NPC) through EB virus antibody profile by enzyme linked immunosorbent assay (ELISA). METHODS: EBNA 1/IgA, EBNA 1/IgG and zta/IgG by ELISA and VCA/IgA by immmunoenzymatic method were detected in 121 NPC patients and 332 healthy subjects (HS) in the Pearl river estuary. RESULTS: The sensitivity rates were 85%, 83% and 79% for EBNA 1/IgA, EBNA 1/IgG and zta/IgG, all three of which if combined was the highest 92%. The specificity rates were 86%, 86% and 80% for EBNA 1/IgA, EBNA 1/IgG and zta/IgG, all three of which if combined was also the highest 93%. According to the level of odds ratio, nasopharyngeal carcinoma risk could be divided into 3 groups: low, moderate and high-risk groups. 93% of HS had low risk of NPC with the odds ratio 0.0 to 0.3. 0.4% of HS had high risk of NPC with the odds ratio of 137.9%. CONCLUSION: ELISA is more objective than the traditional immunoenzymatic method in the detection and diagnosis of NPC. The combination of EBNA 1/IgA, EBNA 1/IgG and zta/IgG is able to evaluate the risk of NPC.en_US
dc.languageengen_US
dc.relation.ispartofZhonghua zhong liu za zhi [Chinese journal of oncology]en_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAntibodies, Viral - Analysisen_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshEpstein-Barr Virus Nuclear Antigens - Analysisen_US
dc.subject.meshFemaleen_US
dc.subject.meshHerpesvirus 4, Human - Isolation & Purificationen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNasopharyngeal Neoplasms - Diagnosis - Virologyen_US
dc.subject.meshRisk Factorsen_US
dc.titleAssessment of nasopharyngeal carcinoma risk by EB virus antibody profileen_US
dc.typeArticleen_US
dc.identifier.emailZheng, B:bzheng@hkucc.hku.hken_US
dc.identifier.authorityZheng, B=rp00353en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid12667325-
dc.identifier.scopuseid_2-s2.0-0037665892en_US
dc.identifier.volume24en_US
dc.identifier.issue6en_US
dc.identifier.spage561en_US
dc.identifier.epage563en_US
dc.identifier.scopusauthoridCheng, W=23101970500en_US
dc.identifier.scopusauthoridChen, G=7406538304en_US
dc.identifier.scopusauthoridChen, H=29267451700en_US
dc.identifier.scopusauthoridLuo, R=7202671104en_US
dc.identifier.scopusauthoridWu, Z=7501411909en_US
dc.identifier.scopusauthoridLu, Y=7405479474en_US
dc.identifier.scopusauthoridZheng, B=7201780588en_US
dc.identifier.scopusauthoridJi, M=8229413000en_US
dc.identifier.scopusauthoridLiang, J=16145038900en_US
dc.identifier.scopusauthoridCen, X=55230203100en_US
dc.identifier.scopusauthoridWang, D=7407072857en_US
dc.identifier.scopusauthoridZong, Y=7005203474en_US
dc.identifier.scopusauthoridWu, W=7407077602en_US

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