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Article: Antibody-based resistance to plant pathogens

TitleAntibody-based resistance to plant pathogens
Authors
Issue Date2001
PublisherSpringer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0962-8819
Citation
Transgenic Research, 2001, v. 10 n. 1, p. 1-12 How to Cite?
AbstractPlant diseases are a major threat to the world food supply, as up to 15% of production is lost to pathogens. In the past, disease control and the generation of resistant plant lines protected against viral, bacterial or fungal pathogens, was achieved using conventional breeding based on crossings, mutant screenings and backcrossing. Many approaches in this field have failed or the resistance obtained has been rapidly broken by the pathogens. Recent advances in molecular biotechnology have made it possible to obtain and to modify genes that are useful for generating disease resistant crops. Several strategies, including expression of pathogen-derived sequences or anti-pathogenic agents, have been developed to engineer improved pathogen resistance in transgenic plants. Antibody-based resistance is a novel strategy for generating transgenic plants resistant to pathogens. Decades ago it was shown that polyclonal and monoclonal antibodies can neutralize viruses, bacteria and selected fungi. This approach has been improved recently by the development of recombinant antibodies (rAbs). Crop resistance can be engineered by the expression of pathogen-specific antibodies, antibody fragments or antibody fusion proteins. The advantages of this approach are that rAbs can be engineered against almost any target molecule, and it has been demonstrated that expression of functional pathogen-specific rAbs in plants confers effective pathogen protection. The efficacy of antibody-based resistance was first shown for plant viruses and its application to other plant pathogens is becoming more established. However, successful use of antibodies to generate plant pathogen resistance relies on appropriate target selection, careful antibody design, efficient antibody expression, stability and targeting to appropriate cellular compartments.
Persistent Identifierhttp://hdl.handle.net/10722/157327
ISSN
2015 Impact Factor: 2.054
2015 SCImago Journal Rankings: 0.932
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSchillberg, Sen_US
dc.contributor.authorZimmermann, Sen_US
dc.contributor.authorZhang, MYen_US
dc.contributor.authorFischer, Ren_US
dc.date.accessioned2012-08-08T08:48:57Z-
dc.date.available2012-08-08T08:48:57Z-
dc.date.issued2001en_US
dc.identifier.citationTransgenic Research, 2001, v. 10 n. 1, p. 1-12en_US
dc.identifier.issn0962-8819en_US
dc.identifier.urihttp://hdl.handle.net/10722/157327-
dc.description.abstractPlant diseases are a major threat to the world food supply, as up to 15% of production is lost to pathogens. In the past, disease control and the generation of resistant plant lines protected against viral, bacterial or fungal pathogens, was achieved using conventional breeding based on crossings, mutant screenings and backcrossing. Many approaches in this field have failed or the resistance obtained has been rapidly broken by the pathogens. Recent advances in molecular biotechnology have made it possible to obtain and to modify genes that are useful for generating disease resistant crops. Several strategies, including expression of pathogen-derived sequences or anti-pathogenic agents, have been developed to engineer improved pathogen resistance in transgenic plants. Antibody-based resistance is a novel strategy for generating transgenic plants resistant to pathogens. Decades ago it was shown that polyclonal and monoclonal antibodies can neutralize viruses, bacteria and selected fungi. This approach has been improved recently by the development of recombinant antibodies (rAbs). Crop resistance can be engineered by the expression of pathogen-specific antibodies, antibody fragments or antibody fusion proteins. The advantages of this approach are that rAbs can be engineered against almost any target molecule, and it has been demonstrated that expression of functional pathogen-specific rAbs in plants confers effective pathogen protection. The efficacy of antibody-based resistance was first shown for plant viruses and its application to other plant pathogens is becoming more established. However, successful use of antibodies to generate plant pathogen resistance relies on appropriate target selection, careful antibody design, efficient antibody expression, stability and targeting to appropriate cellular compartments.en_US
dc.languageengen_US
dc.publisherSpringer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0962-8819en_US
dc.relation.ispartofTransgenic Researchen_US
dc.subject.meshAntibodies, Viral - Immunologyen_US
dc.subject.meshBiotechnology - Methodsen_US
dc.subject.meshGenes, Planten_US
dc.subject.meshGenetic Engineering - Methodsen_US
dc.subject.meshImmunity, Innateen_US
dc.subject.meshPlant Diseases - Virologyen_US
dc.subject.meshPlants - Genetics - Immunologyen_US
dc.subject.meshPlants, Genetically Modified - Genetics - Immunologyen_US
dc.titleAntibody-based resistance to plant pathogensen_US
dc.typeArticleen_US
dc.identifier.emailZhang, MY:zhangmy@hku.hken_US
dc.identifier.authorityZhang, MY=rp01409en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1023/A:1008945126359en_US
dc.identifier.pmid11252378-
dc.identifier.scopuseid_2-s2.0-0035119811en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035119811&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume10en_US
dc.identifier.issue1en_US
dc.identifier.spage1en_US
dc.identifier.epage12en_US
dc.identifier.isiWOS:000166545500001-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridSchillberg, S=6701655632en_US
dc.identifier.scopusauthoridZimmermann, S=7102073465en_US
dc.identifier.scopusauthoridZhang, MY=35316639300en_US
dc.identifier.scopusauthoridFischer, R=7403086967en_US

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