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Article: Invasive disease due to Mucorales: A case report and review of the literature

TitleInvasive disease due to Mucorales: A case report and review of the literature
Authors
Issue Date2001
PublisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.html
Citation
Hong Kong Medical Journal, 2001, v. 7 n. 2, p. 180-188 How to Cite?
AbstractObjective. To review the mycology, pathogenesis, clinical characteristics, investigations, and treatment modalities of mucormycosis. Data sources. A local case of mucormycosis; MEDLINE and non-MEDLINE search of the literature. Study selection. Key words for the literature search were 'mucormycosis' and 'Mucorales'; all available years of study were reviewed. Data extraction. Original articles, review papers, meta-analyses, and relevant book chapters were reviewed. Data synthesis. Mucormycosis is a fungal infection that is rare but increasingly recognised in the growing population of immunocompromised patients. It is caused by saprophytic non-septate hyphae of the order Mucorales. The pulmonary and disseminated forms commonly occur in patients with haematological malignancy, especially acute leukaemia and lymphoma, and those receiving treatment with immunosuppressive effects. The rhinocerebral form is more prevalent in patients with diabetes mellitus, particularly those with the complication of diabetic ketoacidosis. The use of amphotericin B combined with surgery remains the mainstay of treatment. The prognosis largely depends on prompt correction of the underlying risk factors. New strategies to combat this life-threatening infection will result from better understanding of its pathogenesis. Conclusion. A high index of suspicion is needed, in appropriate clinical settings, to diagnose and aggressively treat this infection in view of the high mortality rate for susceptible patients.
Persistent Identifierhttp://hdl.handle.net/10722/157323
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279
References

 

DC FieldValueLanguage
dc.contributor.authorYeung, CKen_US
dc.contributor.authorCheng, VCCen_US
dc.contributor.authorLie, AKWen_US
dc.contributor.authorYuen, KYen_US
dc.date.accessioned2012-08-08T08:48:55Z-
dc.date.available2012-08-08T08:48:55Z-
dc.date.issued2001en_US
dc.identifier.citationHong Kong Medical Journal, 2001, v. 7 n. 2, p. 180-188en_US
dc.identifier.issn1024-2708en_US
dc.identifier.urihttp://hdl.handle.net/10722/157323-
dc.description.abstractObjective. To review the mycology, pathogenesis, clinical characteristics, investigations, and treatment modalities of mucormycosis. Data sources. A local case of mucormycosis; MEDLINE and non-MEDLINE search of the literature. Study selection. Key words for the literature search were 'mucormycosis' and 'Mucorales'; all available years of study were reviewed. Data extraction. Original articles, review papers, meta-analyses, and relevant book chapters were reviewed. Data synthesis. Mucormycosis is a fungal infection that is rare but increasingly recognised in the growing population of immunocompromised patients. It is caused by saprophytic non-septate hyphae of the order Mucorales. The pulmonary and disseminated forms commonly occur in patients with haematological malignancy, especially acute leukaemia and lymphoma, and those receiving treatment with immunosuppressive effects. The rhinocerebral form is more prevalent in patients with diabetes mellitus, particularly those with the complication of diabetic ketoacidosis. The use of amphotericin B combined with surgery remains the mainstay of treatment. The prognosis largely depends on prompt correction of the underlying risk factors. New strategies to combat this life-threatening infection will result from better understanding of its pathogenesis. Conclusion. A high index of suspicion is needed, in appropriate clinical settings, to diagnose and aggressively treat this infection in view of the high mortality rate for susceptible patients.en_US
dc.languageengen_US
dc.publisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.htmlen_US
dc.relation.ispartofHong Kong Medical Journalen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMucormycosis - Complications - Drug Therapy - Microbiologyen_US
dc.titleInvasive disease due to Mucorales: A case report and review of the literatureen_US
dc.typeArticleen_US
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_US
dc.identifier.authorityYuen, KY=rp00366en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid11514754-
dc.identifier.scopuseid_2-s2.0-0034880601en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034880601&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume7en_US
dc.identifier.issue2en_US
dc.identifier.spage180en_US
dc.identifier.epage188en_US
dc.publisher.placeHong Kongen_US
dc.identifier.scopusauthoridYeung, CK=7201354123en_US
dc.identifier.scopusauthoridCheng, VCC=23670479400en_US
dc.identifier.scopusauthoridLie, AKW=24284842400en_US
dc.identifier.scopusauthoridYuen, KY=36078079100en_US

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