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Article: Sputum elastase in steady-state bronchiectasis

TitleSputum elastase in steady-state bronchiectasis
Authors
Issue Date2000
PublisherAmerican College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.org
Citation
Chest, 2000, v. 117 n. 2, p. 420-426 How to Cite?
AbstractStudy objectives: To study the correlations between sputum elastase output with clinical and sputum inflammatory and microbial factors in steady- state bronchiectasis. Design: Prospective recruitment of patients with bronchiectasis (17 women; 48.5 ± 16.5 years old; FEV 1/FVC, 1.3 ± 0.6/2.1 ± 0.9) for assessment of 24-h sputum output of elastase, bacteria, leukocytes, interleukin (IL)-1β, IL-8, tumor necrosis factor-α, and leukotriene B 4. Clinical variables assessed concomitantly included 24-h sputum volume, lung spirometry, number of lung lobes affected by bronchiectasis, and exacerbation frequency. Setting: Consecutive recruitment of outpatients (n = 30) in steady-state bronchiectasis. Measurements and results: Twenty-four-hour sputum elastase output correlated with 24-h sputum volume (r = 0.79, p = 0.0001); number of bronchiectatic lung lobes (r = 0.54, p = 0.0026); percent predicted FEV 1 (r = -0.48, p = 0.0068); percent predicted FVC (r = -0.49, p = 0.001); and leukocyte output (r = 0.75, p = 0.0001). There was no correlation between the sputum output of bacteria with either inflammatory or enzymatic factors (p > 0.05). Conclusion: Our data highlight the importance of elastase and the possibility of independent roles for enzymatic, inflammatory, and microbial components in the pathogenesis of bronchiectasis. Further research on novel therapy targeting each of these components should be pursued.
Persistent Identifierhttp://hdl.handle.net/10722/157312
ISSN
2015 Impact Factor: 5.94
2015 SCImago Journal Rankings: 3.176
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTsang, KWen_US
dc.contributor.authorChan, KNen_US
dc.contributor.authorHo, PLen_US
dc.contributor.authorZheng, Len_US
dc.contributor.authorOoi, GCen_US
dc.contributor.authorHo, JCMen_US
dc.contributor.authorLam, WKen_US
dc.date.accessioned2012-08-08T08:48:50Z-
dc.date.available2012-08-08T08:48:50Z-
dc.date.issued2000en_US
dc.identifier.citationChest, 2000, v. 117 n. 2, p. 420-426en_US
dc.identifier.issn0012-3692en_US
dc.identifier.urihttp://hdl.handle.net/10722/157312-
dc.description.abstractStudy objectives: To study the correlations between sputum elastase output with clinical and sputum inflammatory and microbial factors in steady- state bronchiectasis. Design: Prospective recruitment of patients with bronchiectasis (17 women; 48.5 ± 16.5 years old; FEV 1/FVC, 1.3 ± 0.6/2.1 ± 0.9) for assessment of 24-h sputum output of elastase, bacteria, leukocytes, interleukin (IL)-1β, IL-8, tumor necrosis factor-α, and leukotriene B 4. Clinical variables assessed concomitantly included 24-h sputum volume, lung spirometry, number of lung lobes affected by bronchiectasis, and exacerbation frequency. Setting: Consecutive recruitment of outpatients (n = 30) in steady-state bronchiectasis. Measurements and results: Twenty-four-hour sputum elastase output correlated with 24-h sputum volume (r = 0.79, p = 0.0001); number of bronchiectatic lung lobes (r = 0.54, p = 0.0026); percent predicted FEV 1 (r = -0.48, p = 0.0068); percent predicted FVC (r = -0.49, p = 0.001); and leukocyte output (r = 0.75, p = 0.0001). There was no correlation between the sputum output of bacteria with either inflammatory or enzymatic factors (p > 0.05). Conclusion: Our data highlight the importance of elastase and the possibility of independent roles for enzymatic, inflammatory, and microbial components in the pathogenesis of bronchiectasis. Further research on novel therapy targeting each of these components should be pursued.en_US
dc.languageengen_US
dc.publisherAmerican College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.orgen_US
dc.relation.ispartofChesten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBronchiectasis - Diagnosis - Enzymologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshForced Expiratory Volume - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInflammation Mediators - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPancreatic Elastase - Blooden_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshSputum - Enzymologyen_US
dc.subject.meshVital Capacity - Physiologyen_US
dc.titleSputum elastase in steady-state bronchiectasisen_US
dc.typeArticleen_US
dc.identifier.emailHo, PL:plho@hkucc.hku.hken_US
dc.identifier.emailHo, JCM:jhocm@hku.hken_US
dc.identifier.authorityHo, PL=rp00406en_US
dc.identifier.authorityHo, JCM=rp00258en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid10669685-
dc.identifier.scopuseid_2-s2.0-0033994202en_US
dc.identifier.hkuros49985-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033994202&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume117en_US
dc.identifier.issue2en_US
dc.identifier.spage420en_US
dc.identifier.epage426en_US
dc.identifier.isiWOS:000085449400024-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridTsang, KW=7201555024en_US
dc.identifier.scopusauthoridChan, KN=15737866400en_US
dc.identifier.scopusauthoridHo, PL=7402211363en_US
dc.identifier.scopusauthoridZheng, L=7403404086en_US
dc.identifier.scopusauthoridOoi, GC=7006176119en_US
dc.identifier.scopusauthoridHo, JCM=7402649981en_US
dc.identifier.scopusauthoridLam, WK=7203021937en_US

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