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Article: Intestinal inflammatory pseudotumour with regional lymph node involvement: Identification of a new bacterium as the aetiological agent

TitleIntestinal inflammatory pseudotumour with regional lymph node involvement: Identification of a new bacterium as the aetiological agent
Authors
Issue Date2000
PublisherJohn Wiley & Sons. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/1130
Citation
Journal Of Pathology, 2000, v. 192 n. 3, p. 289-292 How to Cite?
AbstractInflammatory pseudotumours are the morphological expression of diverse processes such as reactive/reparative, infective, and neoplastic. This paper reports an example of intestinal inflammatory pseudotumour, with identification of a newly characterized bacterium in the lesion. The patient presented with intestinal obstruction. Laparotomy revealed a tumour in the terminal ileum causing stricture, and multiple enlarged regional lymph nodes. Histologically, the tumour and lymph nodes were composed of plump spindle cells disposed in a vague storiform pattern, and associated with lymphocytes and plasma cells. Immunohistochemical studies showed that most of the spindle cells were histiocytes (CD68 positive), prompting a search for a bacterial aetiology, akin to mycobacterial spindle cell pseudotumour. All histochemical stains for micro-organisms were unrewarding. Ultrastructural studies, however, revealed abundant bacteria within the spindle histiocytes. Polymerase chain reaction, using conserved oligonucleotide primers complementary to the 16S rRNA genes of eubacteria, was employed to amplify 16S rRNA gene fragments directly from the involved lymph node tissue. Phylogenetic analysis of the amplified DNA sequences revealed an organism with 99% sequence conformity to Pseudomonas veronii, a bacterium which has hitherto not been implicated in human infection. The importance of searching for an infective agent in inflammatory pseudotumour in the appropriate setting is re-emphasized. Copyright (C) 2000 John Wiley and Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/157308
ISSN
2015 Impact Factor: 7.381
2015 SCImago Journal Rankings: 4.176
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheuk, Wen_US
dc.contributor.authorWoo, PCYen_US
dc.contributor.authorYuen, KYen_US
dc.contributor.authorYu, PHen_US
dc.contributor.authorChan, JKCen_US
dc.date.accessioned2012-08-08T08:48:49Z-
dc.date.available2012-08-08T08:48:49Z-
dc.date.issued2000en_US
dc.identifier.citationJournal Of Pathology, 2000, v. 192 n. 3, p. 289-292en_US
dc.identifier.issn0022-3417en_US
dc.identifier.urihttp://hdl.handle.net/10722/157308-
dc.description.abstractInflammatory pseudotumours are the morphological expression of diverse processes such as reactive/reparative, infective, and neoplastic. This paper reports an example of intestinal inflammatory pseudotumour, with identification of a newly characterized bacterium in the lesion. The patient presented with intestinal obstruction. Laparotomy revealed a tumour in the terminal ileum causing stricture, and multiple enlarged regional lymph nodes. Histologically, the tumour and lymph nodes were composed of plump spindle cells disposed in a vague storiform pattern, and associated with lymphocytes and plasma cells. Immunohistochemical studies showed that most of the spindle cells were histiocytes (CD68 positive), prompting a search for a bacterial aetiology, akin to mycobacterial spindle cell pseudotumour. All histochemical stains for micro-organisms were unrewarding. Ultrastructural studies, however, revealed abundant bacteria within the spindle histiocytes. Polymerase chain reaction, using conserved oligonucleotide primers complementary to the 16S rRNA genes of eubacteria, was employed to amplify 16S rRNA gene fragments directly from the involved lymph node tissue. Phylogenetic analysis of the amplified DNA sequences revealed an organism with 99% sequence conformity to Pseudomonas veronii, a bacterium which has hitherto not been implicated in human infection. The importance of searching for an infective agent in inflammatory pseudotumour in the appropriate setting is re-emphasized. Copyright (C) 2000 John Wiley and Sons, Ltd.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/1130en_US
dc.relation.ispartofJournal of Pathologyen_US
dc.rightsJournal of Pathology. Copyright © John Wiley & Sons Ltd.-
dc.subject.meshGranuloma, Plasma Cell - Etiology - Metabolism - Pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshIleal Diseases - Etiology - Metabolism - Pathologyen_US
dc.subject.meshLymphatic Diseases - Etiology - Metabolism - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMicroscopy, Electronen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOligonucleotide Probesen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPseudomonas Infections - Complications - Metabolism - Pathologyen_US
dc.subject.meshRna, Bacterialen_US
dc.subject.meshSequence Analysis, Rnaen_US
dc.titleIntestinal inflammatory pseudotumour with regional lymph node involvement: Identification of a new bacterium as the aetiological agenten_US
dc.typeArticleen_US
dc.identifier.emailWoo, PCY:pcywoo@hkucc.hku.hken_US
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_US
dc.identifier.authorityWoo, PCY=rp00430en_US
dc.identifier.authorityYuen, KY=rp00366en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/1096-9896(2000)9999:9999<::AID-PATH767>3.0.CO;2-Fen_US
dc.identifier.pmid11054710-
dc.identifier.scopuseid_2-s2.0-0033651434en_US
dc.identifier.hkuros61732-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033651434&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume192en_US
dc.identifier.issue3en_US
dc.identifier.spage289en_US
dc.identifier.epage292en_US
dc.identifier.isiWOS:000165505600003-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridCheuk, W=7003958432en_US
dc.identifier.scopusauthoridWoo, PCY=7201801340en_US
dc.identifier.scopusauthoridYuen, KY=36078079100en_US
dc.identifier.scopusauthoridYu, PH=36168916600en_US
dc.identifier.scopusauthoridChan, JKC=7403287069en_US

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