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Article: Emergence of Streptococcus pneumoniae with high-level resistance to cefotaxime in Hong Kong

TitleEmergence of Streptococcus pneumoniae with high-level resistance to cefotaxime in Hong Kong
Authors
KeywordsCefotaxime/Adverse Effects
Drug Resistance, Microbial
Microbial Sensitivity Tests
Pneumococcal Infections/Drug Therapy
Streptococcus Pneumoniae/Drug Effects
Issue Date1999
PublisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.html
Citation
Hong Kong Medical Journal, 1999, v. 5 n. 4, p. 406-409 How to Cite?
AbstractWe report on two cases of pneumococcal infection caused by strains demonstrating high-level cefotaxime resistance (minimal inhibitory concentration, 4 μg/mL). One patient had acute community-acquired meningitis with bacteraemia and the other had bacteraemia probably as a result of nosocomial pneumonia. Both patients died despite treatment with third generation cephalosporins. This is the first report from Hong Kong of infection with Streptococcus pneumonia with high-level cefotaxime resistance that resulted in death. The emergence of high-level resistance to third- generation cephalosporins will result in treatment failure when these agents or penicillin are used alone, especially in cases of severe infection, such as meningitis, in which drug penetration of the blood-brain barrier is critical. The treatment of severe infections due to these isolates is problematic. Indiscriminate use of life-saving third-generation cephalosporins as out-patient treatment of minor infections or as first-line therapy for uncomplicated community-acquired infections in the hospital and in the community should be discouraged.
Persistent Identifierhttp://hdl.handle.net/10722/157303
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorWong, SSYen_US
dc.contributor.authorWoo, PCYen_US
dc.contributor.authorHo, PLen_US
dc.contributor.authorCheng, VCCen_US
dc.contributor.authorYuen, KYen_US
dc.date.accessioned2012-08-08T08:48:47Z-
dc.date.available2012-08-08T08:48:47Z-
dc.date.issued1999en_US
dc.identifier.citationHong Kong Medical Journal, 1999, v. 5 n. 4, p. 406-409en_US
dc.identifier.issn1024-2708en_US
dc.identifier.urihttp://hdl.handle.net/10722/157303-
dc.description.abstractWe report on two cases of pneumococcal infection caused by strains demonstrating high-level cefotaxime resistance (minimal inhibitory concentration, 4 μg/mL). One patient had acute community-acquired meningitis with bacteraemia and the other had bacteraemia probably as a result of nosocomial pneumonia. Both patients died despite treatment with third generation cephalosporins. This is the first report from Hong Kong of infection with Streptococcus pneumonia with high-level cefotaxime resistance that resulted in death. The emergence of high-level resistance to third- generation cephalosporins will result in treatment failure when these agents or penicillin are used alone, especially in cases of severe infection, such as meningitis, in which drug penetration of the blood-brain barrier is critical. The treatment of severe infections due to these isolates is problematic. Indiscriminate use of life-saving third-generation cephalosporins as out-patient treatment of minor infections or as first-line therapy for uncomplicated community-acquired infections in the hospital and in the community should be discouraged.en_US
dc.languageengen_US
dc.publisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.htmlen_US
dc.relation.ispartofHong Kong Medical Journalen_US
dc.subjectCefotaxime/Adverse Effectsen_US
dc.subjectDrug Resistance, Microbialen_US
dc.subjectMicrobial Sensitivity Testsen_US
dc.subjectPneumococcal Infections/Drug Therapyen_US
dc.subjectStreptococcus Pneumoniae/Drug Effectsen_US
dc.titleEmergence of Streptococcus pneumoniae with high-level resistance to cefotaxime in Hong Kongen_US
dc.typeArticleen_US
dc.identifier.emailWong, SSY:samsonsy@hkucc.hku.hken_US
dc.identifier.emailWoo, PCY:pcywoo@hkucc.hku.hken_US
dc.identifier.emailHo, PL:plho@hkucc.hku.hken_US
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_US
dc.identifier.authorityWong, SSY=rp00395en_US
dc.identifier.authorityWoo, PCY=rp00430en_US
dc.identifier.authorityHo, PL=rp00406en_US
dc.identifier.authorityYuen, KY=rp00366en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-0033369992en_US
dc.identifier.volume5en_US
dc.identifier.issue4en_US
dc.identifier.spage406en_US
dc.identifier.epage409en_US
dc.publisher.placeHong Kongen_US
dc.identifier.scopusauthoridWong, SSY=13310021400en_US
dc.identifier.scopusauthoridWoo, PCY=7201801340en_US
dc.identifier.scopusauthoridHo, PL=7402211363en_US
dc.identifier.scopusauthoridCheng, VCC=23670479400en_US
dc.identifier.scopusauthoridYuen, KY=36078079100en_US

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