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Article: Ribotoxins are a more widespread group of proteins within the filamentous fungi than previously believed

TitleRibotoxins are a more widespread group of proteins within the filamentous fungi than previously believed
Authors
Issue Date1999
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/toxicon
Citation
Toxicon, 1999, v. 37 n. 11, p. 1549-1563 How to Cite?
Abstractα-Sarcin, restrictocin and mitogillin are the best known members of the family of fungal ribotoxins. In recent years, new members of this family have been discovered and characterised. In this work, we study the occurrence of ribotoxins among different species of fungi. The presence of ribotoxins has been identified in some new species by means of genetic studies, as well as expression and activity assays. The ribotoxin genes have been partially sequenced, and demonstrate a high degree of similarity. These studies demonstrate that these toxins are more widespread than previously considered. This is surprising, considering the ribotoxins are such specific and potent toxins, of unknown biological function. These studies confirm the hypothesis that these proteins are naturally engineered toxins derived from ribonucleases of broad substrate specificity. Copyright (C) 1999 Elsevier Science Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/157301
ISSN
2015 Impact Factor: 2.309
2015 SCImago Journal Rankings: 0.889
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMartínezRuiz, Aen_US
dc.contributor.authorKao, Ren_US
dc.contributor.authorDavies, Jen_US
dc.contributor.authorMartínez Del Pozo, Aen_US
dc.date.accessioned2012-08-08T08:48:46Z-
dc.date.available2012-08-08T08:48:46Z-
dc.date.issued1999en_US
dc.identifier.citationToxicon, 1999, v. 37 n. 11, p. 1549-1563en_US
dc.identifier.issn0041-0101en_US
dc.identifier.urihttp://hdl.handle.net/10722/157301-
dc.description.abstractα-Sarcin, restrictocin and mitogillin are the best known members of the family of fungal ribotoxins. In recent years, new members of this family have been discovered and characterised. In this work, we study the occurrence of ribotoxins among different species of fungi. The presence of ribotoxins has been identified in some new species by means of genetic studies, as well as expression and activity assays. The ribotoxin genes have been partially sequenced, and demonstrate a high degree of similarity. These studies demonstrate that these toxins are more widespread than previously considered. This is surprising, considering the ribotoxins are such specific and potent toxins, of unknown biological function. These studies confirm the hypothesis that these proteins are naturally engineered toxins derived from ribonucleases of broad substrate specificity. Copyright (C) 1999 Elsevier Science Ltd.en_US
dc.languageengen_US
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/toxiconen_US
dc.relation.ispartofToxiconen_US
dc.subject.meshAllergensen_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshAntibiotics, Antineoplastic - Analysisen_US
dc.subject.meshAntigens, Planten_US
dc.subject.meshAspergillus - Chemistryen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshBlotting, Southernen_US
dc.subject.meshDna, Fungal - Isolation & Purificationen_US
dc.subject.meshEndoribonucleases - Analysisen_US
dc.subject.meshFungal Proteins - Analysisen_US
dc.subject.meshFungi - Chemistryen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshPenicillium - Chemistryen_US
dc.subject.meshPhylogenyen_US
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_US
dc.subject.meshRibonucleases - Analysisen_US
dc.subject.meshRibosomes - Drug Effectsen_US
dc.subject.meshSpores, Fungal - Chemistryen_US
dc.titleRibotoxins are a more widespread group of proteins within the filamentous fungi than previously believeden_US
dc.typeArticleen_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0041-0101(99)00103-8en_US
dc.identifier.pmid10482390-
dc.identifier.scopuseid_2-s2.0-0033231653en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033231653&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume37en_US
dc.identifier.issue11en_US
dc.identifier.spage1549en_US
dc.identifier.epage1563en_US
dc.identifier.isiWOS:000082142600007-
dc.publisher.placeUnited Kingdomen_US

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