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Article: The function of simian chemokine receptors in the replication of SIV

TitleThe function of simian chemokine receptors in the replication of SIV
Authors
Issue Date1998
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/issn/10445323
Citation
Seminars In Immunology, 1998, v. 10 n. 3, p. 215-223 How to Cite?
AbstractThe long sought after co-receptors for primate lentiviruses were identified as belonging to a large family of cell surface proteins - the seven transmembrane proteins. These proteins normally function as cell surface receptors for chemokines and other ligands. The families of genetically divergent Simian Immunodeficiency Viruses (SIV), which include the origins of HIV-1 and HIV-2, use simian and human chemokine receptors as their co-receptors. SIVmac, SIVsm, SIVagm and SIVcpz use monkey and human CCR5 for cell fusion and entry. Human-derived STRL33 (BONZO) and human-derived GPR-15 (BOB) are also used, but with variable efficiency. True primary strains of SIVsm, obtained from the naturally infected simian host, the sooty mangabey, use simian and human CCR5 in a strongly CD4 dependent manner. However, some brain and lymphoid isolates from the experimental simian host, the macaque use CCR5 independently of CD4. Unlike T cell line adapted (TCLA) CXCR4-tropic HIV strains (XR4 HIV), only a few laboratory SIV strains use CXCR4 for entry. Macaque and mangabey CXCR4 are fully functional, because they are highly efficient for entry of XR4 HIV. The CCR5 co-receptor is used by three of four SIV families tested thus far. The fourth family, represented by the isolate, SIVrcm95BG1, is unique among SIV and HIV in its use of CCR2b but not CCR5.
Persistent Identifierhttp://hdl.handle.net/10722/157287
ISSN
2015 Impact Factor: 8.461
2015 SCImago Journal Rankings: 4.866
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMarx, PAen_US
dc.contributor.authorChen, Zen_US
dc.date.accessioned2012-08-08T08:48:40Z-
dc.date.available2012-08-08T08:48:40Z-
dc.date.issued1998en_US
dc.identifier.citationSeminars In Immunology, 1998, v. 10 n. 3, p. 215-223en_US
dc.identifier.issn1044-5323en_US
dc.identifier.urihttp://hdl.handle.net/10722/157287-
dc.description.abstractThe long sought after co-receptors for primate lentiviruses were identified as belonging to a large family of cell surface proteins - the seven transmembrane proteins. These proteins normally function as cell surface receptors for chemokines and other ligands. The families of genetically divergent Simian Immunodeficiency Viruses (SIV), which include the origins of HIV-1 and HIV-2, use simian and human chemokine receptors as their co-receptors. SIVmac, SIVsm, SIVagm and SIVcpz use monkey and human CCR5 for cell fusion and entry. Human-derived STRL33 (BONZO) and human-derived GPR-15 (BOB) are also used, but with variable efficiency. True primary strains of SIVsm, obtained from the naturally infected simian host, the sooty mangabey, use simian and human CCR5 in a strongly CD4 dependent manner. However, some brain and lymphoid isolates from the experimental simian host, the macaque use CCR5 independently of CD4. Unlike T cell line adapted (TCLA) CXCR4-tropic HIV strains (XR4 HIV), only a few laboratory SIV strains use CXCR4 for entry. Macaque and mangabey CXCR4 are fully functional, because they are highly efficient for entry of XR4 HIV. The CCR5 co-receptor is used by three of four SIV families tested thus far. The fourth family, represented by the isolate, SIVrcm95BG1, is unique among SIV and HIV in its use of CCR2b but not CCR5.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/issn/10445323en_US
dc.relation.ispartofSeminars in Immunologyen_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshChemokines - Immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshReceptors, Chemokine - Genetics - Immunologyen_US
dc.subject.meshSequence Alignmenten_US
dc.subject.meshSimian Acquired Immunodeficiency Syndrome - Immunology - Virologyen_US
dc.subject.meshSimian Immunodeficiency Virus - Physiologyen_US
dc.subject.meshVirus Replication - Immunologyen_US
dc.titleThe function of simian chemokine receptors in the replication of SIVen_US
dc.typeArticleen_US
dc.identifier.emailChen, Z:zchenai@hkucc.hku.hken_US
dc.identifier.authorityChen, Z=rp00243en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1006/smim.1998.0135en_US
dc.identifier.pmid9653048-
dc.identifier.scopuseid_2-s2.0-0032104461en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032104461&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume10en_US
dc.identifier.issue3en_US
dc.identifier.spage215en_US
dc.identifier.epage223en_US
dc.identifier.isiWOS:000076581700007-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridMarx, PA=7102894750en_US
dc.identifier.scopusauthoridChen, Z=35271180800en_US

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