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Article: The relative pathogenicity of Candida krusei and C. albicans in the rat oral mucosa

TitleThe relative pathogenicity of Candida krusei and C. albicans in the rat oral mucosa
Authors
Issue Date1998
PublisherSociety for General Microbiology. The Journal's web site is located at http://jmm.sgmjournals.org
Citation
Journal Of Medical Microbiology, 1998, v. 47 n. 12, p. 1047-1057 How to Cite?
AbstractThe relative pathogenicity of Candida krusei and C. albicans was investigated by assessing their colonisation and infectivity of the Sprague-Dawley rat oral mucosa. During an initial 21-week period with intermittent oral inoculation, both Candida spp. demonstrated variable surface colonisation of the oral mucosa. After 3 days of oral inoculation, both yeast species were recovered from all animals. During the 21-week period the mean oral load of C. albicans in the control group of rats varied between (26-274) x 101 cfu/ml whereas the two test groups of rats carrying C. krusei CK9 and CK13 had a mean load of (2-10) x 101 cfu/ml. Although oral colonisation by C. albicans was greater than that of C. krusei, neither species induced candidal infection during this period. Subsequent immunosuppression of the rats by intramuscular cyclophosphamide (40 mg/kg body weight) initiated C. albicans infection of the dorsal tongue (around the conical papillae area) after 4 weeks, in all of three animals while similar lesions due to C. krusei were seen - albeit after 5-7 weeks - in three of eight animals. Characteristic histological changes of mucosal candidosis were discernible on the lingual mucosa of rats infected with both Candida spp. including parakeratosis, absence of a stratum granulosum, thickened rete ridges, micro-abscess formation and polymorph infiltration of the lingual epithelium. Although both species produced fungal hyphae that penetrated the epithelium up to the prickle cell layer, C. albicans hyphae tended to be relatively more profuse. Taken together these results substantiate, for the first time in an animal model, the clinical evidence that C. krusei, once considered an innocuous commensal, is capable of transforming into an invasive pathogen under conditions of immunosuppression.
Persistent Identifierhttp://hdl.handle.net/10722/157284
ISSN
2015 Impact Factor: 2.269
2015 SCImago Journal Rankings: 1.060
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSamaranayake, YHen_US
dc.contributor.authorWu, PCen_US
dc.contributor.authorSamaranayake, LPen_US
dc.contributor.authorHo, PLen_US
dc.date.accessioned2012-08-08T08:48:39Z-
dc.date.available2012-08-08T08:48:39Z-
dc.date.issued1998en_US
dc.identifier.citationJournal Of Medical Microbiology, 1998, v. 47 n. 12, p. 1047-1057en_US
dc.identifier.issn0022-2615en_US
dc.identifier.urihttp://hdl.handle.net/10722/157284-
dc.description.abstractThe relative pathogenicity of Candida krusei and C. albicans was investigated by assessing their colonisation and infectivity of the Sprague-Dawley rat oral mucosa. During an initial 21-week period with intermittent oral inoculation, both Candida spp. demonstrated variable surface colonisation of the oral mucosa. After 3 days of oral inoculation, both yeast species were recovered from all animals. During the 21-week period the mean oral load of C. albicans in the control group of rats varied between (26-274) x 101 cfu/ml whereas the two test groups of rats carrying C. krusei CK9 and CK13 had a mean load of (2-10) x 101 cfu/ml. Although oral colonisation by C. albicans was greater than that of C. krusei, neither species induced candidal infection during this period. Subsequent immunosuppression of the rats by intramuscular cyclophosphamide (40 mg/kg body weight) initiated C. albicans infection of the dorsal tongue (around the conical papillae area) after 4 weeks, in all of three animals while similar lesions due to C. krusei were seen - albeit after 5-7 weeks - in three of eight animals. Characteristic histological changes of mucosal candidosis were discernible on the lingual mucosa of rats infected with both Candida spp. including parakeratosis, absence of a stratum granulosum, thickened rete ridges, micro-abscess formation and polymorph infiltration of the lingual epithelium. Although both species produced fungal hyphae that penetrated the epithelium up to the prickle cell layer, C. albicans hyphae tended to be relatively more profuse. Taken together these results substantiate, for the first time in an animal model, the clinical evidence that C. krusei, once considered an innocuous commensal, is capable of transforming into an invasive pathogen under conditions of immunosuppression.en_US
dc.languageengen_US
dc.publisherSociety for General Microbiology. The Journal's web site is located at http://jmm.sgmjournals.orgen_US
dc.relation.ispartofJournal of Medical Microbiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCandida - Pathogenicityen_US
dc.subject.meshCandida Albicans - Pathogenicityen_US
dc.subject.meshCandidiasis, Oral - Immunology - Microbiology - Pathologyen_US
dc.subject.meshCarrier State - Immunology - Microbiology - Pathologyen_US
dc.subject.meshCyclophosphamideen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshImmunosuppressionen_US
dc.subject.meshImmunosuppressive Agentsen_US
dc.subject.meshLeukocyte Counten_US
dc.subject.meshMaleen_US
dc.subject.meshMouth Mucosa - Microbiology - Pathologyen_US
dc.subject.meshRandom Allocationen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshTongue - Microbiology - Pathologyen_US
dc.titleThe relative pathogenicity of Candida krusei and C. albicans in the rat oral mucosaen_US
dc.typeArticleen_US
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-2615&volume=47&spage=1047&epage=1057&date=1998&atitle=The+relative+pathogenicity+of+Candida+krusei+and+C.+albicans+in+the+rat+oral+mucosa-
dc.identifier.emailSamaranayake, YH: hema@hkucc.hku.hken_US
dc.identifier.emailSamaranayake, LP: lakshman@hku.hken_US
dc.identifier.emailHo, PL: plho@hkucc.hku.hken_US
dc.identifier.authoritySamaranayake, YH=rp00025en_US
dc.identifier.authoritySamaranayake, LP=rp00023en_US
dc.identifier.authorityHo, PL=rp00406en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid9856640-
dc.identifier.scopuseid_2-s2.0-0031755543en_US
dc.identifier.hkuros38957-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031755543&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume47en_US
dc.identifier.issue12en_US
dc.identifier.spage1047en_US
dc.identifier.epage1057en_US
dc.identifier.isiWOS:000077266200004-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridSamaranayake, YH=6602677237en_US
dc.identifier.scopusauthoridWu, PC=7403119323en_US
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_US
dc.identifier.scopusauthoridHo, PL=7402211363en_US

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