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Article: Correlation of in vitro susceptibility testing results for amoxicillin- clavulanate and ampicillin-sulbactam using a panel of lactamase-producing Enterobacteriaceae

TitleCorrelation of in vitro susceptibility testing results for amoxicillin- clavulanate and ampicillin-sulbactam using a panel of lactamase-producing Enterobacteriaceae
Authors
Issue Date1998
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APMIS
Citation
APMIS, 1998, v. 106 n. 9, p. 917-920 How to Cite?
AbstractCorrelation between in vitro susceptibility results for amoxicillin- clavulanate (AMC) and ampicillinsulbactam (SAM) was studied using 136 clinical and control strains of Enterobacteriaceae harboring TEM-1, SHV-1 or OXA-1-like β-lactamases. Determination of minimal inhibitory concentration of antibiotics was performed by agar dilution. The β-lactamases were initially characterized using isoelectric focusing. Further identification was done by DNA hybridization with or without prior PCR amplification. All strains sensitive to SAM were found to be sensitive also to AMC. In contrast, among those susceptible to AMC, only 50% were sensitive to SAM while 36% gave intermediate results and 14% were resistant. Major differences were found solely among SHV-producers while minor differences occurred mostly among TEM- producers. This phenomenon is probably related to the differential activities of etavulanate and sulbactam against various β-lactamases. In conclusion, testing of Enterobacteriaceae isolates for susceptibility to AMC and SAM should be performed and reported individually to avoid erroneous designation of susceptibility.
Persistent Identifierhttp://hdl.handle.net/10722/157283
ISSN
2015 Impact Factor: 1.933
2015 SCImago Journal Rankings: 0.855
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSiu, LKen_US
dc.contributor.authorCheng, WLen_US
dc.contributor.authorHo, PLen_US
dc.contributor.authorNg, WSen_US
dc.contributor.authorChau, PYen_US
dc.contributor.authorLo, JYCen_US
dc.date.accessioned2012-08-08T08:48:38Z-
dc.date.available2012-08-08T08:48:38Z-
dc.date.issued1998en_US
dc.identifier.citationAPMIS, 1998, v. 106 n. 9, p. 917-920en_US
dc.identifier.issn0903-4641en_US
dc.identifier.urihttp://hdl.handle.net/10722/157283-
dc.description.abstractCorrelation between in vitro susceptibility results for amoxicillin- clavulanate (AMC) and ampicillinsulbactam (SAM) was studied using 136 clinical and control strains of Enterobacteriaceae harboring TEM-1, SHV-1 or OXA-1-like β-lactamases. Determination of minimal inhibitory concentration of antibiotics was performed by agar dilution. The β-lactamases were initially characterized using isoelectric focusing. Further identification was done by DNA hybridization with or without prior PCR amplification. All strains sensitive to SAM were found to be sensitive also to AMC. In contrast, among those susceptible to AMC, only 50% were sensitive to SAM while 36% gave intermediate results and 14% were resistant. Major differences were found solely among SHV-producers while minor differences occurred mostly among TEM- producers. This phenomenon is probably related to the differential activities of etavulanate and sulbactam against various β-lactamases. In conclusion, testing of Enterobacteriaceae isolates for susceptibility to AMC and SAM should be performed and reported individually to avoid erroneous designation of susceptibility.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APMISen_US
dc.relation.ispartofAPMISen_US
dc.subject.meshAmoxicillin-Potassium Clavulanate Combination - Pharmacologyen_US
dc.subject.meshAmpicillin - Pharmacologyen_US
dc.subject.meshDrug Therapy, Combination - Pharmacologyen_US
dc.subject.meshEnterobacteriaceae - Drug Effects - Enzymologyen_US
dc.subject.meshIsoelectric Focusingen_US
dc.subject.meshMicrobial Sensitivity Testsen_US
dc.subject.meshNucleic Acid Hybridizationen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshSulbactam - Pharmacologyen_US
dc.subject.meshBeta-Lactam Resistanceen_US
dc.subject.meshBeta-Lactamases - Analysisen_US
dc.titleCorrelation of in vitro susceptibility testing results for amoxicillin- clavulanate and ampicillin-sulbactam using a panel of lactamase-producing Enterobacteriaceaeen_US
dc.typeArticleen_US
dc.identifier.emailHo, PL: plho@hkucc.hku.hken_US
dc.identifier.authorityHo, PL=rp00406en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1699-0463.1998.tb00239.x-
dc.identifier.pmid9808419-
dc.identifier.scopuseid_2-s2.0-0031720694en_US
dc.identifier.hkuros44930-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031720694&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume106en_US
dc.identifier.issue9en_US
dc.identifier.spage917en_US
dc.identifier.epage920en_US
dc.identifier.isiWOS:000076380700011-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridSiu, LK=7006651154en_US
dc.identifier.scopusauthoridCheng, WL=20633800000en_US
dc.identifier.scopusauthoridHo, PL=7402211363en_US
dc.identifier.scopusauthoridNg, WS=36787042500en_US
dc.identifier.scopusauthoridChau, PY=36509704300en_US
dc.identifier.scopusauthoridLo, JYC=7201650939en_US

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