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Article: Human herpesvirus-6 and human herpesvirus-7 infections in bone marrow transplant recipients

TitleHuman herpesvirus-6 and human herpesvirus-7 infections in bone marrow transplant recipients
Authors
KeywordsAntiviral
CMV
Cofactors
Encephalities
Myelosuppression
PCR
Issue Date1997
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/32763
Citation
Journal Of Medical Virology, 1997, v. 53 n. 3, p. 295-305 How to Cite?
AbstractHuman cytomegalovirus (HCMV), human herpesvirus-6 (HHV-6), and human herpesvirus-7 (HHV-7) DNA in peripheral blood leukocytes (PBL) of 61 bone marrow transplant recipients was monitored weekly during the first 12 weeks post-transplantation by a nested polymerase chain reaction (PCR). Thirty- seven (61%), 17 (28%), and 23 (53%) of patients had one or more PBL specimens positive for HCMV, HHV-6 or HHV-7 DNA, respectively. HHV-7 DNA in PBL during the early post-transplant period was associated with a longer time to neutrophil engraftment (mean 28.8 days vs 19.8 days; P = 0.01). In two patients who failed to engraft, HHV-6 DNA and HHV-7 DNA was detected in plasma and PBL, respectively, early in their post-transplant period. Patients with HCMV disease were more likely to have concurrent HHV-7 DNA in PBL prior to onset of disease than were patients with asymptomatic HCMV infection, suggesting that HHV-7 may be a cofactor in the progression from HCMV infection to HCMV disease. In the 17 patients (179 specimens) in whom viral DNA in plasma was studied (in addition to PBL), a positive result was found only in 3. In each, viral DNA in plasma appeared to correlate with clinically significant disease. HHV-7 DNA in plasma was associated with encephalitis in an allograft recipient.
Persistent Identifierhttp://hdl.handle.net/10722/157280
ISSN
2015 Impact Factor: 1.998
2015 SCImago Journal Rankings: 1.015
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, PKSen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorYuen, KYen_HK
dc.contributor.authorLiang, RHSen_HK
dc.contributor.authorLau, YLen_HK
dc.contributor.authorChen, FEen_HK
dc.contributor.authorLo, SKFen_HK
dc.contributor.authorCheung, CYen_HK
dc.contributor.authorChan, TKen_HK
dc.contributor.authorNg, MHen_HK
dc.date.accessioned2012-08-08T08:48:37Z-
dc.date.available2012-08-08T08:48:37Z-
dc.date.issued1997en_HK
dc.identifier.citationJournal Of Medical Virology, 1997, v. 53 n. 3, p. 295-305en_HK
dc.identifier.issn0146-6615en_HK
dc.identifier.urihttp://hdl.handle.net/10722/157280-
dc.description.abstractHuman cytomegalovirus (HCMV), human herpesvirus-6 (HHV-6), and human herpesvirus-7 (HHV-7) DNA in peripheral blood leukocytes (PBL) of 61 bone marrow transplant recipients was monitored weekly during the first 12 weeks post-transplantation by a nested polymerase chain reaction (PCR). Thirty- seven (61%), 17 (28%), and 23 (53%) of patients had one or more PBL specimens positive for HCMV, HHV-6 or HHV-7 DNA, respectively. HHV-7 DNA in PBL during the early post-transplant period was associated with a longer time to neutrophil engraftment (mean 28.8 days vs 19.8 days; P = 0.01). In two patients who failed to engraft, HHV-6 DNA and HHV-7 DNA was detected in plasma and PBL, respectively, early in their post-transplant period. Patients with HCMV disease were more likely to have concurrent HHV-7 DNA in PBL prior to onset of disease than were patients with asymptomatic HCMV infection, suggesting that HHV-7 may be a cofactor in the progression from HCMV infection to HCMV disease. In the 17 patients (179 specimens) in whom viral DNA in plasma was studied (in addition to PBL), a positive result was found only in 3. In each, viral DNA in plasma appeared to correlate with clinically significant disease. HHV-7 DNA in plasma was associated with encephalitis in an allograft recipient.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/32763en_HK
dc.relation.ispartofJournal of Medical Virologyen_HK
dc.subjectAntiviralen_HK
dc.subjectCMVen_HK
dc.subjectCofactorsen_HK
dc.subjectEncephalitiesen_HK
dc.subjectMyelosuppressionen_HK
dc.subjectPCRen_HK
dc.subject.meshAcyclovir - Therapeutic Useen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAntiviral Agents - Therapeutic Useen_US
dc.subject.meshBone Marrow Transplantation - Adverse Effectsen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshCytomegalovirus - Drug Effects - Genetics - Isolation & Purificationen_US
dc.subject.meshDna, Viral - Blood - Drug Effectsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGraft Vs Host Diseaseen_US
dc.subject.meshHerpesviridae Infections - Blood - Drug Therapy - Etiologyen_US
dc.subject.meshHerpesvirus 6, Human - Drug Effects - Genetics - Isolation & Purificationen_US
dc.subject.meshHerpesvirus 7, Human - Drug Effects - Genetics - Isolation & Purificationen_US
dc.subject.meshHumansen_US
dc.subject.meshLeukocytes, Mononuclear - Virologyen_US
dc.subject.meshLongitudinal Studiesen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.titleHuman herpesvirus-6 and human herpesvirus-7 infections in bone marrow transplant recipientsen_HK
dc.typeArticleen_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hken_HK
dc.identifier.emailLiang, RHS: rliang@hku.hken_HK
dc.identifier.emailLau, YL: lauylung@hku.hken_HK
dc.identifier.emailCheung, CY: chungey@hkucc.hku.hken_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.identifier.authorityLiang, RHS=rp00345en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.identifier.authorityCheung, CY=rp00404en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/(SICI)1096-9071(199711)53:3<295::AID-JMV20>3.0.CO;2-Fen_HK
dc.identifier.pmid9365899-
dc.identifier.scopuseid_2-s2.0-0031429631en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031429631&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume53en_HK
dc.identifier.issue3en_HK
dc.identifier.spage295en_HK
dc.identifier.epage305en_HK
dc.identifier.isiWOS:A1997YE75500020-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChan, PKS=7403497792en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.scopusauthoridLiang, RHS=26643224900en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.scopusauthoridChen, FE=17934080100en_HK
dc.identifier.scopusauthoridLo, SKF=7401542391en_HK
dc.identifier.scopusauthoridCheung, CY=7202061836en_HK
dc.identifier.scopusauthoridChan, TK=37076590700en_HK
dc.identifier.scopusauthoridNg, MH=7202076421en_HK

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