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Article: Nocardiosis in systemic lupus erythematosus

TitleNocardiosis in systemic lupus erythematosus
Authors
Issue Date1997
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/semarthrit
Citation
Seminars In Arthritis And Rheumatism, 1997, v. 26 n. 4, p. 675-683 How to Cite?
AbstractObjectives: This study was performed to study the clinical presentations, treatment, and outcome of six cases of nocardial infection in the systemic lupus erythematosus (SLE) population living in Hong Kong and compare these cases with those reported in the English literature. Methods: Records of 215 SLE patients who attended our lupus and rheumatology clinics were reviewed, and cases of nocardial infection were retrieved and studied in detail. A Medline search from 1966 to 1995 was performed to identify other reported cases. The microbiology, diagnosis, and treatment strategies of nocardiosis were assessed. Results: Six cases of nocardiosis were found in our lupus series, giving a prevalence of 2.8%. Another 26 cases of nocardial infection in SLE were reported in the literature. All except one were caused by Nocardia asteroides. The lung was the commonest site of involvement (81%), followed by the central nervous system (CNS) (13%). The mortality was high (35%), especially when the CNS was involved (75%). Sulphonamides were the mainstay of treatment, and adjunctive surgical procedures may be needed for suppurative complications. Conclusions: Nocardiosis has been increasingly recognized in SLE. Although still uncommon, it is an important opportunistic infection because it is curable and mortality is usually caused by delay in diagnosis and treatment. A high index of suspicion, an aggressive approach to diagnosis, and early empirical therapy are essential principles of management.
Persistent Identifierhttp://hdl.handle.net/10722/157277
ISSN
2015 Impact Factor: 3.946
2015 SCImago Journal Rankings: 1.659
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChi Chiu Moken_US
dc.contributor.authorKwok Yung Yuenen_US
dc.contributor.authorChak Sing Lauen_US
dc.date.accessioned2012-08-08T08:48:35Z-
dc.date.available2012-08-08T08:48:35Z-
dc.date.issued1997en_US
dc.identifier.citationSeminars In Arthritis And Rheumatism, 1997, v. 26 n. 4, p. 675-683en_US
dc.identifier.issn0049-0172en_US
dc.identifier.urihttp://hdl.handle.net/10722/157277-
dc.description.abstractObjectives: This study was performed to study the clinical presentations, treatment, and outcome of six cases of nocardial infection in the systemic lupus erythematosus (SLE) population living in Hong Kong and compare these cases with those reported in the English literature. Methods: Records of 215 SLE patients who attended our lupus and rheumatology clinics were reviewed, and cases of nocardial infection were retrieved and studied in detail. A Medline search from 1966 to 1995 was performed to identify other reported cases. The microbiology, diagnosis, and treatment strategies of nocardiosis were assessed. Results: Six cases of nocardiosis were found in our lupus series, giving a prevalence of 2.8%. Another 26 cases of nocardial infection in SLE were reported in the literature. All except one were caused by Nocardia asteroides. The lung was the commonest site of involvement (81%), followed by the central nervous system (CNS) (13%). The mortality was high (35%), especially when the CNS was involved (75%). Sulphonamides were the mainstay of treatment, and adjunctive surgical procedures may be needed for suppurative complications. Conclusions: Nocardiosis has been increasingly recognized in SLE. Although still uncommon, it is an important opportunistic infection because it is curable and mortality is usually caused by delay in diagnosis and treatment. A high index of suspicion, an aggressive approach to diagnosis, and early empirical therapy are essential principles of management.en_US
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/semarthriten_US
dc.relation.ispartofSeminars in Arthritis and Rheumatismen_US
dc.subject.meshAdulten_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLupus Erythematosus, Systemic - Epidemiology - Microbiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshNocardia Infections - Epidemiologyen_US
dc.subject.meshOpportunistic Infections - Epidemiologyen_US
dc.subject.meshPrevalenceen_US
dc.titleNocardiosis in systemic lupus erythematosusen_US
dc.typeArticleen_US
dc.identifier.emailKwok Yung Yuen:kyyuen@hkucc.hku.hken_US
dc.identifier.emailChak Sing Lau:cslau@hku.hken_US
dc.identifier.authorityKwok Yung Yuen=rp00366en_US
dc.identifier.authorityChak Sing Lau=rp01348en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0049-0172(97)80003-0en_US
dc.identifier.pmid9062948-
dc.identifier.scopuseid_2-s2.0-0030996276en_US
dc.identifier.volume26en_US
dc.identifier.issue4en_US
dc.identifier.spage675en_US
dc.identifier.epage683en_US
dc.identifier.isiWOS:A1997WK86500003-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChi Chiu Mok=7409717748en_US
dc.identifier.scopusauthoridKwok Yung Yuen=36078079100en_US
dc.identifier.scopusauthoridChak Sing Lau=14035682100en_US

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