File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Fungal ribotoxins: a family of naturally engineered targeted toxins?

TitleFungal ribotoxins: a family of naturally engineered targeted toxins?
Authors
Issue Date1995
PublisherN R C Research Press. The Journal's web site is located at http://pubs.nrc-cnrc.gc.ca/cgi-bin/rp/rp2_desc_e?bcb
Citation
Biochemistry And Cell Biology = Biochimie Et Biologie Cellulaire, 1995, v. 73 n. 11-12, p. 1151-1159 How to Cite?
Abstractalpha-Sarcin, mitogillin, and restrictocin are small (approximately 17 kDa) basic robosome-inactivating proteins (RIPs) produced by the Aspergilli that catalytically inactivate the large ribosomal subunits of all organisms tested to date. These three fungal ribotoxins act as specific ribonucleases by hydrolyzing one single phosphodiester bond in the universally conserved alpha-sarcin domain of 23-28S rRNAs and are among the most potent inhibitors of protein synthesis known. Previous molecular studies of ribotoxins indicated that they belong to the superfamily of ribonucleases and analysis of the mitogillin gene employing PCR-mediated site-specific mutagenesis suggests that certain domains in ribotoxins, which share homologies with motifs in ribosome-related proteins, may be responsible for the targeting of ribotoxins to the ribosome. The applications of the ribotoxins as tools in research and their uses as therapeutic and diagnostic agents are also reviewed in this paper.
Persistent Identifierhttp://hdl.handle.net/10722/157273
ISSN
2015 Impact Factor: 1.527
2015 SCImago Journal Rankings: 0.859
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKao, Ren_US
dc.contributor.authorDavies, Jen_US
dc.date.accessioned2012-08-08T08:48:33Z-
dc.date.available2012-08-08T08:48:33Z-
dc.date.issued1995en_US
dc.identifier.citationBiochemistry And Cell Biology = Biochimie Et Biologie Cellulaire, 1995, v. 73 n. 11-12, p. 1151-1159en_US
dc.identifier.issn0829-8211en_US
dc.identifier.urihttp://hdl.handle.net/10722/157273-
dc.description.abstractalpha-Sarcin, mitogillin, and restrictocin are small (approximately 17 kDa) basic robosome-inactivating proteins (RIPs) produced by the Aspergilli that catalytically inactivate the large ribosomal subunits of all organisms tested to date. These three fungal ribotoxins act as specific ribonucleases by hydrolyzing one single phosphodiester bond in the universally conserved alpha-sarcin domain of 23-28S rRNAs and are among the most potent inhibitors of protein synthesis known. Previous molecular studies of ribotoxins indicated that they belong to the superfamily of ribonucleases and analysis of the mitogillin gene employing PCR-mediated site-specific mutagenesis suggests that certain domains in ribotoxins, which share homologies with motifs in ribosome-related proteins, may be responsible for the targeting of ribotoxins to the ribosome. The applications of the ribotoxins as tools in research and their uses as therapeutic and diagnostic agents are also reviewed in this paper.en_US
dc.languageengen_US
dc.publisherN R C Research Press. The Journal's web site is located at http://pubs.nrc-cnrc.gc.ca/cgi-bin/rp/rp2_desc_e?bcben_US
dc.relation.ispartofBiochemistry and cell biology = Biochimie et biologie cellulaireen_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshAspergillus - Pathogenicityen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshFungal Proteins - Toxicityen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshMycotoxins - Toxicityen_US
dc.subject.meshProtein Structure, Tertiaryen_US
dc.subject.meshRibosomes - Drug Effectsen_US
dc.subject.meshSequence Homology, Amino Aciden_US
dc.titleFungal ribotoxins: a family of naturally engineered targeted toxins?en_US
dc.typeArticleen_US
dc.identifier.emailKao, R:rytkao@hkucc.hku.hken_US
dc.identifier.authorityKao, R=rp00481en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8722032-
dc.identifier.scopuseid_2-s2.0-0029402948en_US
dc.identifier.volume73en_US
dc.identifier.issue11-12en_US
dc.identifier.spage1151en_US
dc.identifier.epage1159en_US
dc.identifier.isiWOS:A1995UE60300044-
dc.publisher.placeCanadaen_US
dc.identifier.scopusauthoridKao, R=7101675499en_US
dc.identifier.scopusauthoridDavies, J=7404982789en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats