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Article: Evidence for potential application of zinc as an antidote to acetaminophen-induced hepatotoxicity

TitleEvidence for potential application of zinc as an antidote to acetaminophen-induced hepatotoxicity
Authors
Issue Date1995
Citation
European Journal Of Pharmacology - Environmental Toxicology And Pharmacology Section, 1995, v. 293 n. 3, p. 217-224 How to Cite?
AbstractThe therapeutic application of zinc sulphate as an antidote to acetaminophen overdose was examined in ICR mice. Hepatotoxicity was induced by a single oral dose of acetaminophen (750 mg/kg). Various treatments (normal saline, 15 or 30 mg/kg zinc sulphate, 150 mg/kg N-acetylcysteine, 15 mg/kg zinc sulphate + 150 mg/kg N-acetylcysteine) were given i.p. 1 h after acetaminophen overdose. Serum alanine aminotransferase, hepatic glutathione and malondialdehyde levels were measured before experiments and at various intervals after the administration of acetaminophen. Serum acetaminophen levels were also measured at different time intervals. Zinc sulphate showed protection by dose-dependently reducing alanine aminotransferase and malondialdehyde levels. The drug also partially prevented the depletion of hepatic glutathione. These effects were not as good as those of N-acetylcysteine. However, the combination of zinc sulphate with N-acetylcysteine produced even better protective effects. Furthermore, drug treatments did not affect serum acetaminophen levels. It is concluded that both drugs attenuate acetaminophen-induced hepatic toxicity, and the action is likely to be mediated through replenishment of hepatic glutathione levels. The use of zinc sulphate alone or in combination with N-acetylcysteine could be another alternative for the treatment of acetaminophen overdose in view of possible side effects produced by N-acetylcysteine.
Persistent Identifierhttp://hdl.handle.net/10722/157272
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWoo, PCYen_US
dc.contributor.authorKaan, SKen_US
dc.contributor.authorCho, CHen_US
dc.date.accessioned2012-08-08T08:48:33Z-
dc.date.available2012-08-08T08:48:33Z-
dc.date.issued1995en_US
dc.identifier.citationEuropean Journal Of Pharmacology - Environmental Toxicology And Pharmacology Section, 1995, v. 293 n. 3, p. 217-224en_US
dc.identifier.issn0926-6917en_US
dc.identifier.urihttp://hdl.handle.net/10722/157272-
dc.description.abstractThe therapeutic application of zinc sulphate as an antidote to acetaminophen overdose was examined in ICR mice. Hepatotoxicity was induced by a single oral dose of acetaminophen (750 mg/kg). Various treatments (normal saline, 15 or 30 mg/kg zinc sulphate, 150 mg/kg N-acetylcysteine, 15 mg/kg zinc sulphate + 150 mg/kg N-acetylcysteine) were given i.p. 1 h after acetaminophen overdose. Serum alanine aminotransferase, hepatic glutathione and malondialdehyde levels were measured before experiments and at various intervals after the administration of acetaminophen. Serum acetaminophen levels were also measured at different time intervals. Zinc sulphate showed protection by dose-dependently reducing alanine aminotransferase and malondialdehyde levels. The drug also partially prevented the depletion of hepatic glutathione. These effects were not as good as those of N-acetylcysteine. However, the combination of zinc sulphate with N-acetylcysteine produced even better protective effects. Furthermore, drug treatments did not affect serum acetaminophen levels. It is concluded that both drugs attenuate acetaminophen-induced hepatic toxicity, and the action is likely to be mediated through replenishment of hepatic glutathione levels. The use of zinc sulphate alone or in combination with N-acetylcysteine could be another alternative for the treatment of acetaminophen overdose in view of possible side effects produced by N-acetylcysteine.en_US
dc.languageengen_US
dc.relation.ispartofEuropean Journal of Pharmacology - Environmental Toxicology and Pharmacology Sectionen_US
dc.subject.meshAcetaminophen - Blood - Toxicityen_US
dc.subject.meshAcetylcysteine - Pharmacologyen_US
dc.subject.meshAlanine Transaminase - Blooden_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntidotes - Pharmacologyen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshDrug-Induced Liver Injury - Blood - Pathology - Prevention & Controlen_US
dc.subject.meshGlutathione - Metabolismen_US
dc.subject.meshLiver - Drug Effects - Metabolism - Pathologyen_US
dc.subject.meshMalondialdehyde - Metabolismen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred Icren_US
dc.subject.meshOverdoseen_US
dc.subject.meshSulfates - Pharmacologyen_US
dc.subject.meshZinc Compounds - Pharmacologyen_US
dc.subject.meshZinc Sulfateen_US
dc.titleEvidence for potential application of zinc as an antidote to acetaminophen-induced hepatotoxicityen_US
dc.typeArticleen_US
dc.identifier.emailWoo, PCY:pcywoo@hkucc.hku.hken_US
dc.identifier.authorityWoo, PCY=rp00430en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8666038-
dc.identifier.scopuseid_2-s2.0-0028980892en_US
dc.identifier.volume293en_US
dc.identifier.issue3en_US
dc.identifier.spage217en_US
dc.identifier.epage224en_US
dc.identifier.isiWOS:A1995TA16800004-
dc.identifier.scopusauthoridWoo, PCY=7201801340en_US
dc.identifier.scopusauthoridKaan, SK=6603358809en_US
dc.identifier.scopusauthoridCho, CH=7403100461en_US

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