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- Publisher Website: 10.1111/j.2042-7158.1994.tb03748.x
- Scopus: eid_2-s2.0-0028201862
- PMID: 7912727
- WOS: WOS:A1994MY78400005
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Article: Effects of β-adrenoceptor antagonists on portal vein hypertension and ethanol-induced gastric mucosal damage in rats
Title | Effects of β-adrenoceptor antagonists on portal vein hypertension and ethanol-induced gastric mucosal damage in rats |
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Authors | |
Issue Date | 1994 |
Publisher | Pharmaceutical Press. The Journal's web site is located at http://www.pharmpress.com/jpp |
Citation | Journal of Pharmacy and Pharmacology, 1994, v. 46 n. 2, p. 95-97 How to Cite? |
Abstract | The effects of various β-adrenoceptor antagonists, with different pharmacological properties, on systemic and portal vein blood pressure and on ethanol-induced gastric mucosal damage were examined in surgically-induced portal hypertensive rats. Propranolol (5, 10 or 20 mg kg-1), nadolol (5 or 10 mg kg-1) metoprolol (10 or 20 mg kg-1), labetalol (20 or 40 mg kg-1) and pindolol (3 or 6 mg kg-1) reduced systemic blood pressure to a similar degree in both portal vein-ligated and sham-operated rats. All β-adrenoceptor antagonists, except for pindolol, significantly reduced portal venous pressure and ethanol-induced macroscopic gastric mucosal damage in portal hypertensive animals. Sham-operated rats had lower portal venous pressure and less gastric damage compared with portal hypertensive rats, but both were unaffected by β-adrenoceptor antagonist pretreatment. We conclude that: propranolol, nadolol, metoprolol and labetalol are effective in reducing the portal venous pressure and ethanol-induced gastric mucosal damage in portal hypertensive rats, but not in portal normotensive animals; there was no direct relationship between the reduction of portal vein and systemic blood pressure, and local anaesthetic action is probably important in reducing the portal vein pressure and ethanol-induced gastric mucosal lesions, while the intrinsic sympathomimetic effect can counteract the actions of the β-adrenoceptor antagonists on portal venous pressure and gastric mucosa. |
Persistent Identifier | http://hdl.handle.net/10722/157268 |
ISSN | 2023 Impact Factor: 2.8 2023 SCImago Journal Rankings: 0.648 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Woo, PCY | en_US |
dc.contributor.author | Cho, CH | en_US |
dc.date.accessioned | 2012-08-08T08:48:32Z | - |
dc.date.available | 2012-08-08T08:48:32Z | - |
dc.date.issued | 1994 | en_US |
dc.identifier.citation | Journal of Pharmacy and Pharmacology, 1994, v. 46 n. 2, p. 95-97 | en_US |
dc.identifier.issn | 0022-3573 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/157268 | - |
dc.description.abstract | The effects of various β-adrenoceptor antagonists, with different pharmacological properties, on systemic and portal vein blood pressure and on ethanol-induced gastric mucosal damage were examined in surgically-induced portal hypertensive rats. Propranolol (5, 10 or 20 mg kg-1), nadolol (5 or 10 mg kg-1) metoprolol (10 or 20 mg kg-1), labetalol (20 or 40 mg kg-1) and pindolol (3 or 6 mg kg-1) reduced systemic blood pressure to a similar degree in both portal vein-ligated and sham-operated rats. All β-adrenoceptor antagonists, except for pindolol, significantly reduced portal venous pressure and ethanol-induced macroscopic gastric mucosal damage in portal hypertensive animals. Sham-operated rats had lower portal venous pressure and less gastric damage compared with portal hypertensive rats, but both were unaffected by β-adrenoceptor antagonist pretreatment. We conclude that: propranolol, nadolol, metoprolol and labetalol are effective in reducing the portal venous pressure and ethanol-induced gastric mucosal damage in portal hypertensive rats, but not in portal normotensive animals; there was no direct relationship between the reduction of portal vein and systemic blood pressure, and local anaesthetic action is probably important in reducing the portal vein pressure and ethanol-induced gastric mucosal lesions, while the intrinsic sympathomimetic effect can counteract the actions of the β-adrenoceptor antagonists on portal venous pressure and gastric mucosa. | en_US |
dc.language | eng | en_US |
dc.publisher | Pharmaceutical Press. The Journal's web site is located at http://www.pharmpress.com/jpp | en_US |
dc.relation.ispartof | Journal of Pharmacy and Pharmacology | en_US |
dc.subject.mesh | Adrenergic Beta-Antagonists - Pharmacology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Ethanol | en_US |
dc.subject.mesh | Gastric Mucosa - Drug Effects - Pathology | en_US |
dc.subject.mesh | Hemodynamics | en_US |
dc.subject.mesh | Hypertension, Portal - Drug Therapy | en_US |
dc.subject.mesh | Labetalol - Pharmacology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Metoprolol - Pharmacology | en_US |
dc.subject.mesh | Nadolol - Pharmacology | en_US |
dc.subject.mesh | Pindolol - Pharmacology | en_US |
dc.subject.mesh | Propranolol - Pharmacology | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Sprague-Dawley | en_US |
dc.subject.mesh | Stomach Ulcer - Chemically Induced - Drug Therapy - Pathology | en_US |
dc.title | Effects of β-adrenoceptor antagonists on portal vein hypertension and ethanol-induced gastric mucosal damage in rats | en_US |
dc.type | Article | en_US |
dc.identifier.email | Woo, PCY: pcywoo@hkucc.hku.hk | en_US |
dc.identifier.authority | Woo, PCY=rp00430 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1111/j.2042-7158.1994.tb03748.x | - |
dc.identifier.pmid | 7912727 | - |
dc.identifier.scopus | eid_2-s2.0-0028201862 | en_US |
dc.identifier.hkuros | 27431 | - |
dc.identifier.volume | 46 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 95 | en_US |
dc.identifier.epage | 97 | en_US |
dc.identifier.isi | WOS:A1994MY78400005 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Woo, PCY=7201801340 | en_US |
dc.identifier.scopusauthorid | Cho, CH=7403100461 | en_US |
dc.customcontrol.immutable | sml 130530 | - |
dc.identifier.issnl | 0022-3573 | - |