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Article: Effects of β-adrenoceptor antagonists on portal vein hypertension and ethanol-induced gastric mucosal damage in rats

TitleEffects of β-adrenoceptor antagonists on portal vein hypertension and ethanol-induced gastric mucosal damage in rats
Authors
Issue Date1994
PublisherPharmaceutical Press. The Journal's web site is located at http://www.pharmpress.com/jpp
Citation
Journal of Pharmacy and Pharmacology, 1994, v. 46 n. 2, p. 95-97 How to Cite?
AbstractThe effects of various β-adrenoceptor antagonists, with different pharmacological properties, on systemic and portal vein blood pressure and on ethanol-induced gastric mucosal damage were examined in surgically-induced portal hypertensive rats. Propranolol (5, 10 or 20 mg kg-1), nadolol (5 or 10 mg kg-1) metoprolol (10 or 20 mg kg-1), labetalol (20 or 40 mg kg-1) and pindolol (3 or 6 mg kg-1) reduced systemic blood pressure to a similar degree in both portal vein-ligated and sham-operated rats. All β-adrenoceptor antagonists, except for pindolol, significantly reduced portal venous pressure and ethanol-induced macroscopic gastric mucosal damage in portal hypertensive animals. Sham-operated rats had lower portal venous pressure and less gastric damage compared with portal hypertensive rats, but both were unaffected by β-adrenoceptor antagonist pretreatment. We conclude that: propranolol, nadolol, metoprolol and labetalol are effective in reducing the portal venous pressure and ethanol-induced gastric mucosal damage in portal hypertensive rats, but not in portal normotensive animals; there was no direct relationship between the reduction of portal vein and systemic blood pressure, and local anaesthetic action is probably important in reducing the portal vein pressure and ethanol-induced gastric mucosal lesions, while the intrinsic sympathomimetic effect can counteract the actions of the β-adrenoceptor antagonists on portal venous pressure and gastric mucosa.
Persistent Identifierhttp://hdl.handle.net/10722/157268
ISSN
2015 Impact Factor: 2.363
2015 SCImago Journal Rankings: 0.686

 

DC FieldValueLanguage
dc.contributor.authorWoo, PCYen_US
dc.contributor.authorCho, CHen_US
dc.date.accessioned2012-08-08T08:48:32Z-
dc.date.available2012-08-08T08:48:32Z-
dc.date.issued1994en_US
dc.identifier.citationJournal of Pharmacy and Pharmacology, 1994, v. 46 n. 2, p. 95-97en_US
dc.identifier.issn0022-3573en_US
dc.identifier.urihttp://hdl.handle.net/10722/157268-
dc.description.abstractThe effects of various β-adrenoceptor antagonists, with different pharmacological properties, on systemic and portal vein blood pressure and on ethanol-induced gastric mucosal damage were examined in surgically-induced portal hypertensive rats. Propranolol (5, 10 or 20 mg kg-1), nadolol (5 or 10 mg kg-1) metoprolol (10 or 20 mg kg-1), labetalol (20 or 40 mg kg-1) and pindolol (3 or 6 mg kg-1) reduced systemic blood pressure to a similar degree in both portal vein-ligated and sham-operated rats. All β-adrenoceptor antagonists, except for pindolol, significantly reduced portal venous pressure and ethanol-induced macroscopic gastric mucosal damage in portal hypertensive animals. Sham-operated rats had lower portal venous pressure and less gastric damage compared with portal hypertensive rats, but both were unaffected by β-adrenoceptor antagonist pretreatment. We conclude that: propranolol, nadolol, metoprolol and labetalol are effective in reducing the portal venous pressure and ethanol-induced gastric mucosal damage in portal hypertensive rats, but not in portal normotensive animals; there was no direct relationship between the reduction of portal vein and systemic blood pressure, and local anaesthetic action is probably important in reducing the portal vein pressure and ethanol-induced gastric mucosal lesions, while the intrinsic sympathomimetic effect can counteract the actions of the β-adrenoceptor antagonists on portal venous pressure and gastric mucosa.en_US
dc.languageengen_US
dc.publisherPharmaceutical Press. The Journal's web site is located at http://www.pharmpress.com/jppen_US
dc.relation.ispartofJournal of Pharmacy and Pharmacologyen_US
dc.subject.meshAdrenergic Beta-Antagonists - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshEthanolen_US
dc.subject.meshGastric Mucosa - Drug Effects - Pathologyen_US
dc.subject.meshHemodynamicsen_US
dc.subject.meshHypertension, Portal - Drug Therapyen_US
dc.subject.meshLabetalol - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMetoprolol - Pharmacologyen_US
dc.subject.meshNadolol - Pharmacologyen_US
dc.subject.meshPindolol - Pharmacologyen_US
dc.subject.meshPropranolol - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshStomach Ulcer - Chemically Induced - Drug Therapy - Pathologyen_US
dc.titleEffects of β-adrenoceptor antagonists on portal vein hypertension and ethanol-induced gastric mucosal damage in ratsen_US
dc.typeArticleen_US
dc.identifier.emailWoo, PCY: pcywoo@hkucc.hku.hken_US
dc.identifier.authorityWoo, PCY=rp00430en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.2042-7158.1994.tb03748.x-
dc.identifier.pmid7912727-
dc.identifier.scopuseid_2-s2.0-0028201862en_US
dc.identifier.hkuros27431-
dc.identifier.volume46en_US
dc.identifier.issue2en_US
dc.identifier.spage95en_US
dc.identifier.epage97en_US
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridWoo, PCY=7201801340en_US
dc.identifier.scopusauthoridCho, CH=7403100461en_US
dc.customcontrol.immutablesml 130530-

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