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Article: Disseminated Penicillium marneffei infection responding to treatment with oral fluconazole

TitleDisseminated Penicillium marneffei infection responding to treatment with oral fluconazole
Authors
KeywordsDisseminated Infection
Fluconazole
Penicillium Marneffei
Issue Date1992
Citation
Journal Of The Hong Kong Medical Association, 1992, v. 44 n. 3, p. 176-180 How to Cite?
AbstractAn ill and stunted 17-year-old boy with biopsy and culture proven recurrent disseminated Penicillium marneffei infection and possible immune deficiency (natural killer cell defect) (1) manifested progressive disease despite receiving repeated prolonged courses of intravenous amphotericin B (cumulative dose 5.33 g over seven years) and (2) there were unacceptable treatment complications (venous thrombophlebitis and febrile reactions). Dramatic subjective and objective improvement ensued, when treatment was changed to oral fluconazole (300 mg daily). Thereafter, all of his various lesions (including those in bone, lymph nodes and other soft tissues) regressed, excepting one superior mediastinal mass which enlarged and was shown to be normal thymic tissue. Having received out-patient fluconazole therapy for just over a year, the patient remains active and virtually asymptomatic; there being no evidence of persisting infection.
Persistent Identifierhttp://hdl.handle.net/10722/157257
ISSN

 

DC FieldValueLanguage
dc.contributor.authorLau, GKKen_US
dc.contributor.authorKumana, CRen_US
dc.contributor.authorWong, KLen_US
dc.contributor.authorYuen, KYen_US
dc.contributor.authorChau, PYen_US
dc.contributor.authorChan, FLen_US
dc.contributor.authorJones, BMen_US
dc.date.accessioned2012-08-08T08:48:28Z-
dc.date.available2012-08-08T08:48:28Z-
dc.date.issued1992en_US
dc.identifier.citationJournal Of The Hong Kong Medical Association, 1992, v. 44 n. 3, p. 176-180en_US
dc.identifier.issn1010-8424en_US
dc.identifier.urihttp://hdl.handle.net/10722/157257-
dc.description.abstractAn ill and stunted 17-year-old boy with biopsy and culture proven recurrent disseminated Penicillium marneffei infection and possible immune deficiency (natural killer cell defect) (1) manifested progressive disease despite receiving repeated prolonged courses of intravenous amphotericin B (cumulative dose 5.33 g over seven years) and (2) there were unacceptable treatment complications (venous thrombophlebitis and febrile reactions). Dramatic subjective and objective improvement ensued, when treatment was changed to oral fluconazole (300 mg daily). Thereafter, all of his various lesions (including those in bone, lymph nodes and other soft tissues) regressed, excepting one superior mediastinal mass which enlarged and was shown to be normal thymic tissue. Having received out-patient fluconazole therapy for just over a year, the patient remains active and virtually asymptomatic; there being no evidence of persisting infection.en_US
dc.languageengen_US
dc.relation.ispartofJournal of the Hong Kong Medical Associationen_US
dc.subjectDisseminated Infectionen_US
dc.subjectFluconazoleen_US
dc.subjectPenicillium Marneffeien_US
dc.titleDisseminated Penicillium marneffei infection responding to treatment with oral fluconazoleen_US
dc.typeArticleen_US
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_US
dc.identifier.authorityYuen, KY=rp00366en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-0026968717en_US
dc.identifier.volume44en_US
dc.identifier.issue3en_US
dc.identifier.spage176en_US
dc.identifier.epage180en_US
dc.publisher.placeHong Kongen_US
dc.identifier.scopusauthoridLau, GKK=7102301257en_US
dc.identifier.scopusauthoridKumana, CR=7005112381en_US
dc.identifier.scopusauthoridWong, KL=7404759833en_US
dc.identifier.scopusauthoridYuen, KY=36078079100en_US
dc.identifier.scopusauthoridChau, PY=36509704300en_US
dc.identifier.scopusauthoridChan, FL=54913448800en_US
dc.identifier.scopusauthoridJones, BM=7404958958en_US

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