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Article: Distinct populations of rotaviruses circulating among neonates and older infants

TitleDistinct populations of rotaviruses circulating among neonates and older infants
Authors
Issue Date1990
Citation
Journal Of Clinical Microbiology, 1990, v. 28 n. 5, p. 1033-1038 How to Cite?
AbstractWe obtained three stool specimens from each of 371 neonates. Two specimens were obtained between days 1 and 3 after birth, while they were in the hospital, and one specimen was obtained between days 6 and 14 after birth, after they had been discharged from the hospital. Seventy neonates excreted human rotavirus (HRV) while they were in the hospital, and the incidence rate for the cohort was 0.094 episodes per infant day. The incidence rate of community-acquired neonatal infections was markedly reduced to 0.022 episodes per infant day, with eight additional episodes of infection being detected after the infants were discharged from the hospital. Nevertheless, this was higher than the incidence of community-acquired HRV infection of 0.0037 episodes per infant day previously estimated by serology for the same cohort during the subsequent 2 years of infancy. None of the 78 episodes of neonatal HRV infection was accompanied by diarrhea. There were at least 44 distinct electropherotypes of HRV circulating among older infants in the community during the study period, and they comprised at least four different serotypes. Despite the genetic and antigenic diversity of the prevalent HRV isolates, only five electropherotypes with either serotype 2 or 4 specificity were isolated from the neonates, while serotype 1 and 3 viruses were not detected. Two of these electropherotypes, including one which was isolated from 57 of the 78 infants with episodes of infection, were isolated exclusively from the neonates. The other three electropherotypes were also isolated from the older infants; one was a major electropherotype and two were minor electropherotypes which were prevalent among the older infants. These results suggest that distinct populations of HRV cocirculate among neonates and older infants.
Persistent Identifierhttp://hdl.handle.net/10722/157245
ISSN
2015 Impact Factor: 3.631
2015 SCImago Journal Rankings: 2.151
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTam, JSLen_US
dc.contributor.authorZheng, BJen_US
dc.contributor.authorLo, SKen_US
dc.contributor.authorYeung, CYen_US
dc.contributor.authorLo, Men_US
dc.contributor.authorNg, MHen_US
dc.date.accessioned2012-08-08T08:48:22Z-
dc.date.available2012-08-08T08:48:22Z-
dc.date.issued1990en_US
dc.identifier.citationJournal Of Clinical Microbiology, 1990, v. 28 n. 5, p. 1033-1038en_US
dc.identifier.issn0095-1137en_US
dc.identifier.urihttp://hdl.handle.net/10722/157245-
dc.description.abstractWe obtained three stool specimens from each of 371 neonates. Two specimens were obtained between days 1 and 3 after birth, while they were in the hospital, and one specimen was obtained between days 6 and 14 after birth, after they had been discharged from the hospital. Seventy neonates excreted human rotavirus (HRV) while they were in the hospital, and the incidence rate for the cohort was 0.094 episodes per infant day. The incidence rate of community-acquired neonatal infections was markedly reduced to 0.022 episodes per infant day, with eight additional episodes of infection being detected after the infants were discharged from the hospital. Nevertheless, this was higher than the incidence of community-acquired HRV infection of 0.0037 episodes per infant day previously estimated by serology for the same cohort during the subsequent 2 years of infancy. None of the 78 episodes of neonatal HRV infection was accompanied by diarrhea. There were at least 44 distinct electropherotypes of HRV circulating among older infants in the community during the study period, and they comprised at least four different serotypes. Despite the genetic and antigenic diversity of the prevalent HRV isolates, only five electropherotypes with either serotype 2 or 4 specificity were isolated from the neonates, while serotype 1 and 3 viruses were not detected. Two of these electropherotypes, including one which was isolated from 57 of the 78 infants with episodes of infection, were isolated exclusively from the neonates. The other three electropherotypes were also isolated from the older infants; one was a major electropherotype and two were minor electropherotypes which were prevalent among the older infants. These results suggest that distinct populations of HRV cocirculate among neonates and older infants.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Clinical Microbiologyen_US
dc.subject.meshAge Factorsen_US
dc.subject.meshDiarrhea - Microbiologyen_US
dc.subject.meshFeces - Microbiologyen_US
dc.subject.meshHong Kong - Epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshRotavirus - Classification - Isolation & Purificationen_US
dc.subject.meshRotavirus Infections - Epidemiology - Microbiologyen_US
dc.subject.meshSeroepidemiologic Studiesen_US
dc.subject.meshSerotypingen_US
dc.titleDistinct populations of rotaviruses circulating among neonates and older infantsen_US
dc.typeArticleen_US
dc.identifier.emailZheng, BJ:bzheng@hkucc.hku.hken_US
dc.identifier.authorityZheng, BJ=rp00353en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2161863-
dc.identifier.scopuseid_2-s2.0-0025308069en_US
dc.identifier.volume28en_US
dc.identifier.issue5en_US
dc.identifier.spage1033en_US
dc.identifier.epage1038en_US
dc.identifier.isiWOS:A1990CZ59600042-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridTam, JSL=24788939600en_US
dc.identifier.scopusauthoridZheng, BJ=7201780588en_US
dc.identifier.scopusauthoridLo, SK=7401542391en_US
dc.identifier.scopusauthoridYeung, CY=7201354144en_US
dc.identifier.scopusauthoridLo, M=7101896986en_US
dc.identifier.scopusauthoridNg, MH=7202076421en_US

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