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Article: Prolonged release from PLGA/HAp scaffolds containing drug-loaded PLGA/gelatin composite microspheres

TitleProlonged release from PLGA/HAp scaffolds containing drug-loaded PLGA/gelatin composite microspheres
Authors
Issue Date2012
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0957-4530
Citation
Journal of Materials Science: Materials in Medicine, 2012, v. 23 n. 2, p. 419-429 How to Cite?
AbstractPorous scaffolds that can prolong the release of bioactive factors are urgently required in bone tissue engineering. In this study, PLGA/gelatin composite microspheres (PGMs) were carefully designed and prepared by entrapping poly(L: -lactide-co-glycolide) (PLGA) microspheres (PMs) in gelatin matrix. By mixing PGMs with PLGA solution directly, drug-loaded PLGA/carbonated hydroxyapatite (HAp)/PGMs composite scaffolds were successfully fabricated. In vitro release of fluorescein isothiocyanate-dextran (FD70S) as a model drug from the scaffolds as well as PMs and PGMs was studied by immersing samples in phosphate buffered saline (pH = 7.4) at 37 degrees C for 32 days. Compared with PMs, PGMs and PLGA/HAp/PGMs scaffolds exhibited slow and steady release behavior with constant release rate and insignificantly original burst release. The swelling of PGMs, diffusion of drugs, and degradation of polymer dominated the release behaviors synergistically. The PLGA/HAp/PGMs scaffold offers a novel option for sequential or simultaneous release of several drugs in terms of bone regeneration.
Persistent Identifierhttp://hdl.handle.net/10722/157158
ISSN
2014 Impact Factor: 2.587
2013 SCImago Journal Rankings: 0.926
ISI Accession Number ID
Funding AgencyGrant Number
Natural Science Foundation of China30828008
51073117
Scientific Research Foundation of Graduate School of Tianjin University
Funding Information:

This work was supported by Natural Science Foundation of China via grant Nos. 30828008 and 51073117 and also by the Scientific Research Foundation of Graduate School of Tianjin University.

 

DC FieldValueLanguage
dc.contributor.authorTang, Gen_US
dc.contributor.authorZhang, Hen_US
dc.contributor.authorZhao, Yen_US
dc.contributor.authorLi, Xen_US
dc.contributor.authorYuan, Xen_US
dc.contributor.authorWang, Men_US
dc.date.accessioned2012-08-08T08:45:35Z-
dc.date.available2012-08-08T08:45:35Z-
dc.date.issued2012en_US
dc.identifier.citationJournal of Materials Science: Materials in Medicine, 2012, v. 23 n. 2, p. 419-429en_US
dc.identifier.issn0957-4530en_US
dc.identifier.urihttp://hdl.handle.net/10722/157158-
dc.description.abstractPorous scaffolds that can prolong the release of bioactive factors are urgently required in bone tissue engineering. In this study, PLGA/gelatin composite microspheres (PGMs) were carefully designed and prepared by entrapping poly(L: -lactide-co-glycolide) (PLGA) microspheres (PMs) in gelatin matrix. By mixing PGMs with PLGA solution directly, drug-loaded PLGA/carbonated hydroxyapatite (HAp)/PGMs composite scaffolds were successfully fabricated. In vitro release of fluorescein isothiocyanate-dextran (FD70S) as a model drug from the scaffolds as well as PMs and PGMs was studied by immersing samples in phosphate buffered saline (pH = 7.4) at 37 degrees C for 32 days. Compared with PMs, PGMs and PLGA/HAp/PGMs scaffolds exhibited slow and steady release behavior with constant release rate and insignificantly original burst release. The swelling of PGMs, diffusion of drugs, and degradation of polymer dominated the release behaviors synergistically. The PLGA/HAp/PGMs scaffold offers a novel option for sequential or simultaneous release of several drugs in terms of bone regeneration.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0957-4530en_US
dc.relation.ispartofJournal of Materials Science: Materials in Medicineen_US
dc.rightsThe original publication is available at www.springerlink.com-
dc.subject.meshDurapatite - chemistry-
dc.subject.meshGelatin - chemistry-
dc.subject.meshLactic Acid - chemistry-
dc.subject.meshMicrospheres-
dc.subject.meshPolyglycolic Acid - chemistry-
dc.titleProlonged release from PLGA/HAp scaffolds containing drug-loaded PLGA/gelatin composite microspheresen_US
dc.typeArticleen_US
dc.identifier.emailYuan, X: yuanxy@tju.edu.cnen_US
dc.identifier.emailWang, M: memwang@hku.hk-
dc.identifier.authorityWang, M=rp00185en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s10856-011-4493-2en_US
dc.identifier.pmid22095448-
dc.identifier.scopuseid_2-s2.0-84863441856en_US
dc.identifier.hkuros207521-
dc.identifier.volume23-
dc.identifier.issue2-
dc.identifier.spage419en_US
dc.identifier.epage429en_US
dc.identifier.isiWOS:000301640800022-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWang, M=15749714100en_US
dc.identifier.scopusauthoridYuan, X=7402202655en_US
dc.identifier.scopusauthoridLi, X=36012686700en_US
dc.identifier.scopusauthoridZhao, Y=7406633316en_US
dc.identifier.scopusauthoridZhang, H=36071184600en_US
dc.identifier.scopusauthoridTang, G=23494188700en_US
dc.identifier.citeulike10053218-

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