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Article: Prolonged release from PLGA/HAp scaffolds containing drug-loaded PLGA/gelatin composite microspheres
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TitleProlonged release from PLGA/HAp scaffolds containing drug-loaded PLGA/gelatin composite microspheres
 
AuthorsTang, G2
Zhang, H2
Zhao, Y2
Li, X2
Yuan, X2
Wang, M1
 
Issue Date2012
 
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0957-4530
 
CitationJournal of Materials Science: Materials in Medicine, 2012, v. 23 n. 2, p. 419-429 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s10856-011-4493-2
 
AbstractPorous scaffolds that can prolong the release of bioactive factors are urgently required in bone tissue engineering. In this study, PLGA/gelatin composite microspheres (PGMs) were carefully designed and prepared by entrapping poly(L: -lactide-co-glycolide) (PLGA) microspheres (PMs) in gelatin matrix. By mixing PGMs with PLGA solution directly, drug-loaded PLGA/carbonated hydroxyapatite (HAp)/PGMs composite scaffolds were successfully fabricated. In vitro release of fluorescein isothiocyanate-dextran (FD70S) as a model drug from the scaffolds as well as PMs and PGMs was studied by immersing samples in phosphate buffered saline (pH = 7.4) at 37 degrees C for 32 days. Compared with PMs, PGMs and PLGA/HAp/PGMs scaffolds exhibited slow and steady release behavior with constant release rate and insignificantly original burst release. The swelling of PGMs, diffusion of drugs, and degradation of polymer dominated the release behaviors synergistically. The PLGA/HAp/PGMs scaffold offers a novel option for sequential or simultaneous release of several drugs in terms of bone regeneration.
 
ISSN0957-4530
2012 Impact Factor: 2.141
 
DOIhttp://dx.doi.org/10.1007/s10856-011-4493-2
 
ISI Accession Number IDWOS:000301640800022
Funding AgencyGrant Number
Natural Science Foundation of China30828008
51073117
Scientific Research Foundation of Graduate School of Tianjin University
Funding Information:

This work was supported by Natural Science Foundation of China via grant Nos. 30828008 and 51073117 and also by the Scientific Research Foundation of Graduate School of Tianjin University.

 
DC FieldValue
dc.contributor.authorTang, G
 
dc.contributor.authorZhang, H
 
dc.contributor.authorZhao, Y
 
dc.contributor.authorLi, X
 
dc.contributor.authorYuan, X
 
dc.contributor.authorWang, M
 
dc.date.accessioned2012-08-08T08:45:35Z
 
dc.date.available2012-08-08T08:45:35Z
 
dc.date.issued2012
 
dc.description.abstractPorous scaffolds that can prolong the release of bioactive factors are urgently required in bone tissue engineering. In this study, PLGA/gelatin composite microspheres (PGMs) were carefully designed and prepared by entrapping poly(L: -lactide-co-glycolide) (PLGA) microspheres (PMs) in gelatin matrix. By mixing PGMs with PLGA solution directly, drug-loaded PLGA/carbonated hydroxyapatite (HAp)/PGMs composite scaffolds were successfully fabricated. In vitro release of fluorescein isothiocyanate-dextran (FD70S) as a model drug from the scaffolds as well as PMs and PGMs was studied by immersing samples in phosphate buffered saline (pH = 7.4) at 37 degrees C for 32 days. Compared with PMs, PGMs and PLGA/HAp/PGMs scaffolds exhibited slow and steady release behavior with constant release rate and insignificantly original burst release. The swelling of PGMs, diffusion of drugs, and degradation of polymer dominated the release behaviors synergistically. The PLGA/HAp/PGMs scaffold offers a novel option for sequential or simultaneous release of several drugs in terms of bone regeneration.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationJournal of Materials Science: Materials in Medicine, 2012, v. 23 n. 2, p. 419-429 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s10856-011-4493-2
 
dc.identifier.citeulike10053218
 
dc.identifier.doihttp://dx.doi.org/10.1007/s10856-011-4493-2
 
dc.identifier.epage429
 
dc.identifier.hkuros207521
 
dc.identifier.isiWOS:000301640800022
Funding AgencyGrant Number
Natural Science Foundation of China30828008
51073117
Scientific Research Foundation of Graduate School of Tianjin University
Funding Information:

This work was supported by Natural Science Foundation of China via grant Nos. 30828008 and 51073117 and also by the Scientific Research Foundation of Graduate School of Tianjin University.

 
dc.identifier.issn0957-4530
2012 Impact Factor: 2.141
 
dc.identifier.issue2
 
dc.identifier.pmid22095448
 
dc.identifier.scopuseid_2-s2.0-84863441856
 
dc.identifier.spage419
 
dc.identifier.urihttp://hdl.handle.net/10722/157158
 
dc.identifier.volume23
 
dc.languageeng
 
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0957-4530
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Materials Science: Materials in Medicine
 
dc.rightsThe original publication is available at www.springerlink.com
 
dc.subject.meshDurapatite - chemistry
 
dc.subject.meshGelatin - chemistry
 
dc.subject.meshLactic Acid - chemistry
 
dc.subject.meshMicrospheres
 
dc.subject.meshPolyglycolic Acid - chemistry
 
dc.titleProlonged release from PLGA/HAp scaffolds containing drug-loaded PLGA/gelatin composite microspheres
 
dc.typeArticle
 
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<item><contributor.author>Tang, G</contributor.author>
<contributor.author>Zhang, H</contributor.author>
<contributor.author>Zhao, Y</contributor.author>
<contributor.author>Li, X</contributor.author>
<contributor.author>Yuan, X</contributor.author>
<contributor.author>Wang, M</contributor.author>
<date.accessioned>2012-08-08T08:45:35Z</date.accessioned>
<date.available>2012-08-08T08:45:35Z</date.available>
<date.issued>2012</date.issued>
<identifier.citation>Journal of Materials Science: Materials in Medicine, 2012, v. 23 n. 2, p. 419-429</identifier.citation>
<identifier.issn>0957-4530</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/157158</identifier.uri>
<description.abstract>Porous scaffolds that can prolong the release of bioactive factors are urgently required in bone tissue engineering. In this study, PLGA/gelatin composite microspheres (PGMs) were carefully designed and prepared by entrapping poly(L: -lactide-co-glycolide) (PLGA) microspheres (PMs) in gelatin matrix. By mixing PGMs with PLGA solution directly, drug-loaded PLGA/carbonated hydroxyapatite (HAp)/PGMs composite scaffolds were successfully fabricated. In vitro release of fluorescein isothiocyanate-dextran (FD70S) as a model drug from the scaffolds as well as PMs and PGMs was studied by immersing samples in phosphate buffered saline (pH = 7.4) at 37 degrees C for 32 days. Compared with PMs, PGMs and PLGA/HAp/PGMs scaffolds exhibited slow and steady release behavior with constant release rate and insignificantly original burst release. The swelling of PGMs, diffusion of drugs, and degradation of polymer dominated the release behaviors synergistically. The PLGA/HAp/PGMs scaffold offers a novel option for sequential or simultaneous release of several drugs in terms of bone regeneration.</description.abstract>
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<subject.mesh>Durapatite - chemistry</subject.mesh>
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Author Affiliations
  1. The University of Hong Kong
  2. Tianjin University