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Article: A new nanofiber fabrication technique based on coaxial electrospinning

TitleA new nanofiber fabrication technique based on coaxial electrospinning
Authors
KeywordsBiological response
Coaxial electrospinning
Core-shell
Electrospuns
Fabrication technique
Issue Date2012
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/matlet
Citation
Materials Letters, 2012, v. 66 n. 1, p. 257-260 How to Cite?
AbstractIn tissue engineering, nanofibrous scaffolds can achieve better biological responses than microfibrous scaffolds and electrospinning is a common method for producing fibrous scaffolds. However, not all biopolymers can be made into nanofibers through conventional electrospinning. The current investigation developed an innovative nanofiber fabrication technique based on coaxial electrospinning and used poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) as an example for achieving nanofibers. For obtaining PHBV nanofibers, core-shell structured fibers were fabricated first via coaxial electrospinning, with PHBV being the core and chitosan being the shell. The chitosan shell was then removed by washing electrospun scaffolds with water, leading to the formation of nanofibrous PHBV scaffolds. The PHBV nanofiber diameter was affected by the inner polymer (i.e., PHBV) solution concentration during coaxial electrospinning, which can be explained in terms of the coaxial electrospinning process and polymer solution viscosity. Compared to the approach of using a conductivity-enhancing salt in polymer solution to produce polymer nanofibers, the new technique not only eliminates the biocompatibility concerns but also provides a more effective way of reducing fiber diameters to the nano-size range. © 2011 Elsevier B.V.
Persistent Identifierhttp://hdl.handle.net/10722/157146
ISSN
2014 Impact Factor: 2.489
2014 SCImago Journal Rankings: 0.850
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTong, HWen_US
dc.contributor.authorZhang, Xen_US
dc.contributor.authorWang, Men_US
dc.date.accessioned2012-08-08T08:45:32Z-
dc.date.available2012-08-08T08:45:32Z-
dc.date.issued2012en_US
dc.identifier.citationMaterials Letters, 2012, v. 66 n. 1, p. 257-260en_US
dc.identifier.issn0167-577Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/157146-
dc.description.abstractIn tissue engineering, nanofibrous scaffolds can achieve better biological responses than microfibrous scaffolds and electrospinning is a common method for producing fibrous scaffolds. However, not all biopolymers can be made into nanofibers through conventional electrospinning. The current investigation developed an innovative nanofiber fabrication technique based on coaxial electrospinning and used poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) as an example for achieving nanofibers. For obtaining PHBV nanofibers, core-shell structured fibers were fabricated first via coaxial electrospinning, with PHBV being the core and chitosan being the shell. The chitosan shell was then removed by washing electrospun scaffolds with water, leading to the formation of nanofibrous PHBV scaffolds. The PHBV nanofiber diameter was affected by the inner polymer (i.e., PHBV) solution concentration during coaxial electrospinning, which can be explained in terms of the coaxial electrospinning process and polymer solution viscosity. Compared to the approach of using a conductivity-enhancing salt in polymer solution to produce polymer nanofibers, the new technique not only eliminates the biocompatibility concerns but also provides a more effective way of reducing fiber diameters to the nano-size range. © 2011 Elsevier B.V.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/matleten_US
dc.relation.ispartofMaterials Lettersen_US
dc.subjectBiological responseen_US
dc.subjectCoaxial electrospinningen_US
dc.subjectCore-shellen_US
dc.subjectElectrospunsen_US
dc.subjectFabrication techniqueen_US
dc.titleA new nanofiber fabrication technique based on coaxial electrospinningen_US
dc.typeArticleen_US
dc.identifier.emailTong, HW: meboris@hku.hken_US
dc.identifier.emailWang, M: memwang@hku.hk-
dc.identifier.authorityWang, M=rp00185en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.matlet.2011.08.095en_US
dc.identifier.scopuseid_2-s2.0-80053174879en_US
dc.identifier.hkuros204410-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80053174879&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume66en_US
dc.identifier.issue1en_US
dc.identifier.spage257en_US
dc.identifier.epage260en_US
dc.identifier.isiWOS:000297660300077-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridWang, M=15749714100en_US
dc.identifier.scopusauthoridZhang, X=36066911900en_US
dc.identifier.scopusauthoridTong, HW=23476100900en_US

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