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Article: A new nanofiber fabrication technique based on coaxial electrospinning
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TitleA new nanofiber fabrication technique based on coaxial electrospinning
 
AuthorsTong, HW1
Zhang, X1
Wang, M1
 
KeywordsBiological response
Coaxial electrospinning
Core-shell
Electrospuns
Fabrication technique
 
Issue Date2012
 
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/matlet
 
CitationMaterials Letters, 2012, v. 66 n. 1, p. 257-260 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.matlet.2011.08.095
 
AbstractIn tissue engineering, nanofibrous scaffolds can achieve better biological responses than microfibrous scaffolds and electrospinning is a common method for producing fibrous scaffolds. However, not all biopolymers can be made into nanofibers through conventional electrospinning. The current investigation developed an innovative nanofiber fabrication technique based on coaxial electrospinning and used poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) as an example for achieving nanofibers. For obtaining PHBV nanofibers, core-shell structured fibers were fabricated first via coaxial electrospinning, with PHBV being the core and chitosan being the shell. The chitosan shell was then removed by washing electrospun scaffolds with water, leading to the formation of nanofibrous PHBV scaffolds. The PHBV nanofiber diameter was affected by the inner polymer (i.e., PHBV) solution concentration during coaxial electrospinning, which can be explained in terms of the coaxial electrospinning process and polymer solution viscosity. Compared to the approach of using a conductivity-enhancing salt in polymer solution to produce polymer nanofibers, the new technique not only eliminates the biocompatibility concerns but also provides a more effective way of reducing fiber diameters to the nano-size range. © 2011 Elsevier B.V.
 
ISSN0167-577X
2013 Impact Factor: 2.269
2013 SCImago Journal Rankings: 0.898
 
DOIhttp://dx.doi.org/10.1016/j.matlet.2011.08.095
 
ISI Accession Number IDWOS:000297660300077
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorTong, HW
 
dc.contributor.authorZhang, X
 
dc.contributor.authorWang, M
 
dc.date.accessioned2012-08-08T08:45:32Z
 
dc.date.available2012-08-08T08:45:32Z
 
dc.date.issued2012
 
dc.description.abstractIn tissue engineering, nanofibrous scaffolds can achieve better biological responses than microfibrous scaffolds and electrospinning is a common method for producing fibrous scaffolds. However, not all biopolymers can be made into nanofibers through conventional electrospinning. The current investigation developed an innovative nanofiber fabrication technique based on coaxial electrospinning and used poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) as an example for achieving nanofibers. For obtaining PHBV nanofibers, core-shell structured fibers were fabricated first via coaxial electrospinning, with PHBV being the core and chitosan being the shell. The chitosan shell was then removed by washing electrospun scaffolds with water, leading to the formation of nanofibrous PHBV scaffolds. The PHBV nanofiber diameter was affected by the inner polymer (i.e., PHBV) solution concentration during coaxial electrospinning, which can be explained in terms of the coaxial electrospinning process and polymer solution viscosity. Compared to the approach of using a conductivity-enhancing salt in polymer solution to produce polymer nanofibers, the new technique not only eliminates the biocompatibility concerns but also provides a more effective way of reducing fiber diameters to the nano-size range. © 2011 Elsevier B.V.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationMaterials Letters, 2012, v. 66 n. 1, p. 257-260 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.matlet.2011.08.095
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.matlet.2011.08.095
 
dc.identifier.epage260
 
dc.identifier.hkuros204410
 
dc.identifier.isiWOS:000297660300077
 
dc.identifier.issn0167-577X
2013 Impact Factor: 2.269
2013 SCImago Journal Rankings: 0.898
 
dc.identifier.issue1
 
dc.identifier.scopuseid_2-s2.0-80053174879
 
dc.identifier.spage257
 
dc.identifier.urihttp://hdl.handle.net/10722/157146
 
dc.identifier.volume66
 
dc.languageeng
 
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/matlet
 
dc.publisher.placeNetherlands
 
dc.relation.ispartofMaterials Letters
 
dc.relation.referencesReferences in Scopus
 
dc.subjectBiological response
 
dc.subjectCoaxial electrospinning
 
dc.subjectCore-shell
 
dc.subjectElectrospuns
 
dc.subjectFabrication technique
 
dc.titleA new nanofiber fabrication technique based on coaxial electrospinning
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong