Article: A new nanofiber fabrication technique based on coaxial electrospinning

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TitleA new nanofiber fabrication technique based on coaxial electrospinning
AuthorsTong, HW1
Zhang, X1
Wang, M1
KeywordsBiological response
Coaxial electrospinning
Core-shell
Electrospuns
Fabrication technique
Issue Date2012
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/matlet
CitationMaterials Letters, 2012, v. 66 n. 1, p. 257-260 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.matlet.2011.08.095
AbstractIn tissue engineering, nanofibrous scaffolds can achieve better biological responses than microfibrous scaffolds and electrospinning is a common method for producing fibrous scaffolds. However, not all biopolymers can be made into nanofibers through conventional electrospinning. The current investigation developed an innovative nanofiber fabrication technique based on coaxial electrospinning and used poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) as an example for achieving nanofibers. For obtaining PHBV nanofibers, core-shell structured fibers were fabricated first via coaxial electrospinning, with PHBV being the core and chitosan being the shell. The chitosan shell was then removed by washing electrospun scaffolds with water, leading to the formation of nanofibrous PHBV scaffolds. The PHBV nanofiber diameter was affected by the inner polymer (i.e., PHBV) solution concentration during coaxial electrospinning, which can be explained in terms of the coaxial electrospinning process and polymer solution viscosity. Compared to the approach of using a conductivity-enhancing salt in polymer solution to produce polymer nanofibers, the new technique not only eliminates the biocompatibility concerns but also provides a more effective way of reducing fiber diameters to the nano-size range. © 2011 Elsevier B.V.
ISSN0167-577X
2011 Impact Factor: 2.307
2011 SCImago Journal Rankings: 0.164
DOIhttp://dx.doi.org/10.1016/j.matlet.2011.08.095
ISI Accession Number IDWOS:000297660300077
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorTong, HW
dc.contributor.authorZhang, X
dc.contributor.authorWang, M
dc.date.accessioned2012-08-08T08:45:32Z
dc.date.available2012-08-08T08:45:32Z
dc.date.issued2012
dc.description.abstractIn tissue engineering, nanofibrous scaffolds can achieve better biological responses than microfibrous scaffolds and electrospinning is a common method for producing fibrous scaffolds. However, not all biopolymers can be made into nanofibers through conventional electrospinning. The current investigation developed an innovative nanofiber fabrication technique based on coaxial electrospinning and used poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) as an example for achieving nanofibers. For obtaining PHBV nanofibers, core-shell structured fibers were fabricated first via coaxial electrospinning, with PHBV being the core and chitosan being the shell. The chitosan shell was then removed by washing electrospun scaffolds with water, leading to the formation of nanofibrous PHBV scaffolds. The PHBV nanofiber diameter was affected by the inner polymer (i.e., PHBV) solution concentration during coaxial electrospinning, which can be explained in terms of the coaxial electrospinning process and polymer solution viscosity. Compared to the approach of using a conductivity-enhancing salt in polymer solution to produce polymer nanofibers, the new technique not only eliminates the biocompatibility concerns but also provides a more effective way of reducing fiber diameters to the nano-size range. © 2011 Elsevier B.V.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationMaterials Letters, 2012, v. 66 n. 1, p. 257-260 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.matlet.2011.08.095
dc.identifier.doihttp://dx.doi.org/10.1016/j.matlet.2011.08.095
dc.identifier.epage260
dc.identifier.hkuros204410
dc.identifier.isiWOS:000297660300077
dc.identifier.issn0167-577X
2011 Impact Factor: 2.307
2011 SCImago Journal Rankings: 0.164
dc.identifier.issue1
dc.identifier.scopuseid_2-s2.0-80053174879
dc.identifier.spage257
dc.identifier.urihttp://hdl.handle.net/10722/157146
dc.identifier.volume66
dc.languageeng
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/matlet
dc.publisher.placeNetherlands
dc.relation.ispartofMaterials Letters
dc.relation.referencesReferences in Scopus
dc.subjectBiological response
dc.subjectCoaxial electrospinning
dc.subjectCore-shell
dc.subjectElectrospuns
dc.subjectFabrication technique
dc.titleA new nanofiber fabrication technique based on coaxial electrospinning
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong