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Article: Multiple polymersomes for programmed release of multiple components

TitleMultiple polymersomes for programmed release of multiple components
Authors
Issue Date2011
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.html
Citation
Journal Of The American Chemical Society, 2011, v. 133 n. 38, p. 15165-15171 How to Cite?
AbstractLong-term storage and controlled release of multiple components while avoiding cross-contamination have potentially important applications for pharmaceuticals and cosmetics. Polymersomes are very promising delivery vehicles but cannot be used to encapsulate multiple independent components and release them in a controlled manner. Here, we report a microfluidic approach to produce multiple polymersomes, or polymersomes-in-polymersome by design, enabling encapsulation and programmed release of multiple components. Monodisperse polymersomes are prepared from templates of double-emulsion drops, which in turn are injected as the innermost phase to form the second level of double-emulsion drops, producing double polymersomes. Using the same strategy, higher-order polymersomes are also prepared. In addition, incorporation of hydrophobic homopolymer into the different bilayers of the multiple polymersomes enables controlled and sequential dissociation of the different bilayer membranes in a programmed fashion. The high encapsulation efficiency of this microfluidic approach, as well as its programmability and the biocompatibility of the materials used to form the polymersomes, will provide new opportunities for practical delivery systems of multiple components. © 2011 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/157145
ISSN
2015 Impact Factor: 13.038
2015 SCImago Journal Rankings: 7.123
ISI Accession Number ID
Funding AgencyGrant Number
Amore-Pacific
NSFDMR-1006546
Harvard MRSECDMR-0820484
Capsum
Funding Information:

This work was supported by Amore-Pacific, Capsum, and the NSF (DMR-1006546) and the Harvard MRSEC (DMR-0820484).

References

 

DC FieldValueLanguage
dc.contributor.authorKim, SHen_US
dc.contributor.authorShum, HCen_US
dc.contributor.authorKim, JWen_US
dc.contributor.authorCho, JCen_US
dc.contributor.authorWeitz, DAen_US
dc.date.accessioned2012-08-08T08:45:31Z-
dc.date.available2012-08-08T08:45:31Z-
dc.date.issued2011en_US
dc.identifier.citationJournal Of The American Chemical Society, 2011, v. 133 n. 38, p. 15165-15171en_US
dc.identifier.issn0002-7863en_US
dc.identifier.urihttp://hdl.handle.net/10722/157145-
dc.description.abstractLong-term storage and controlled release of multiple components while avoiding cross-contamination have potentially important applications for pharmaceuticals and cosmetics. Polymersomes are very promising delivery vehicles but cannot be used to encapsulate multiple independent components and release them in a controlled manner. Here, we report a microfluidic approach to produce multiple polymersomes, or polymersomes-in-polymersome by design, enabling encapsulation and programmed release of multiple components. Monodisperse polymersomes are prepared from templates of double-emulsion drops, which in turn are injected as the innermost phase to form the second level of double-emulsion drops, producing double polymersomes. Using the same strategy, higher-order polymersomes are also prepared. In addition, incorporation of hydrophobic homopolymer into the different bilayers of the multiple polymersomes enables controlled and sequential dissociation of the different bilayer membranes in a programmed fashion. The high encapsulation efficiency of this microfluidic approach, as well as its programmability and the biocompatibility of the materials used to form the polymersomes, will provide new opportunities for practical delivery systems of multiple components. © 2011 American Chemical Society.en_US
dc.languageengen_US
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.htmlen_US
dc.relation.ispartofJournal of the American Chemical Societyen_US
dc.subject.meshLactates - Chemical Synthesis - Chemistryen_US
dc.subject.meshMembranes, Artificialen_US
dc.subject.meshMicrofluidic Analytical Techniquesen_US
dc.subject.meshParticle Sizeen_US
dc.subject.meshPolyethylene Glycols - Chemical Synthesis - Chemistryen_US
dc.subject.meshSurface Propertiesen_US
dc.titleMultiple polymersomes for programmed release of multiple componentsen_US
dc.typeArticleen_US
dc.identifier.emailShum, HC:ashum@hku.hken_US
dc.identifier.authorityShum, HC=rp01439en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1021/ja205687ken_US
dc.identifier.pmid21838246en_US
dc.identifier.scopuseid_2-s2.0-80053074605en_US
dc.identifier.hkuros207255-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80053074605&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume133en_US
dc.identifier.issue38en_US
dc.identifier.spage15165en_US
dc.identifier.epage15171en_US
dc.identifier.isiWOS:000295604400055-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKim, SH=8906177700en_US
dc.identifier.scopusauthoridShum, HC=23976513800en_US
dc.identifier.scopusauthoridKim, JW=48461428900en_US
dc.identifier.scopusauthoridCho, JC=50561111600en_US
dc.identifier.scopusauthoridWeitz, DA=7006798731en_US

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