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Article: In vitro behavior of osteoblast-like cells on PLLA films with a biomimetic apatite or apatite/collagen composite coating

TitleIn vitro behavior of osteoblast-like cells on PLLA films with a biomimetic apatite or apatite/collagen composite coating
Authors
Issue Date2008
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0957-4530
Citation
Journal Of Materials Science: Materials In Medicine, 2008, v. 19 n. 6, p. 2261-2268 How to Cite?
AbstractTo investigate the methods to improve the cell-material interaction of devices or tissue engineering scaffolds made of poly(l-lactic acid) (PLLA) polymer, apatite and apatite/collagen composite coatings were formed on PLLA films within 24 h through accelerated biomimetic processes. In vitro investigation using Saos-2 osteoblast-like cells through cell culture was conducted to assess the biological performance of these biomimetic coatings. The cell morphology on three types of surfaces, viz., PLLA film, PLLA film with the apatite coating, and PLLA film with the apatite/collagen composite coating, was studied using scanning electron microscopy (SEM). Cell viability was estimated using the MTT assay. The differentiated cell function was assessed by measuring the alkaline phosphatase (ALP) activity. The results obtained indicated that the biomimetic apatite and apatite/collagen composite coatings could significantly enhance the proliferation and differentiation of osteoblast-like cells. The apatite/collagen composite coating appears to be promising for the surface modification of PLLA-based devices with much improved interactions with osteoblastic cells. © 2007 Springer Science+Business Media, LLC.
Persistent Identifierhttp://hdl.handle.net/10722/156951
ISSN
2015 Impact Factor: 2.272
2013 SCImago Journal Rankings: 0.897
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, Yen_US
dc.contributor.authorMak, AFTen_US
dc.contributor.authorWang, Men_US
dc.contributor.authorLi, JSen_US
dc.contributor.authorWong, MSen_US
dc.date.accessioned2012-08-08T08:44:41Z-
dc.date.available2012-08-08T08:44:41Z-
dc.date.issued2008en_US
dc.identifier.citationJournal Of Materials Science: Materials In Medicine, 2008, v. 19 n. 6, p. 2261-2268en_US
dc.identifier.issn0957-4530en_US
dc.identifier.urihttp://hdl.handle.net/10722/156951-
dc.description.abstractTo investigate the methods to improve the cell-material interaction of devices or tissue engineering scaffolds made of poly(l-lactic acid) (PLLA) polymer, apatite and apatite/collagen composite coatings were formed on PLLA films within 24 h through accelerated biomimetic processes. In vitro investigation using Saos-2 osteoblast-like cells through cell culture was conducted to assess the biological performance of these biomimetic coatings. The cell morphology on three types of surfaces, viz., PLLA film, PLLA film with the apatite coating, and PLLA film with the apatite/collagen composite coating, was studied using scanning electron microscopy (SEM). Cell viability was estimated using the MTT assay. The differentiated cell function was assessed by measuring the alkaline phosphatase (ALP) activity. The results obtained indicated that the biomimetic apatite and apatite/collagen composite coatings could significantly enhance the proliferation and differentiation of osteoblast-like cells. The apatite/collagen composite coating appears to be promising for the surface modification of PLLA-based devices with much improved interactions with osteoblastic cells. © 2007 Springer Science+Business Media, LLC.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0957-4530en_US
dc.relation.ispartofJournal of Materials Science: Materials in Medicineen_US
dc.subject.meshAlkaline Phosphatase - Metabolismen_US
dc.subject.meshApatites - Chemistryen_US
dc.subject.meshBiocompatible Materials - Chemistryen_US
dc.subject.meshBiomimeticsen_US
dc.subject.meshCell Adhesionen_US
dc.subject.meshCell Culture Techniques - Instrumentationen_US
dc.subject.meshCell Proliferationen_US
dc.subject.meshCollagen - Chemistryen_US
dc.subject.meshEquipment Designen_US
dc.subject.meshHumansen_US
dc.subject.meshLactic Acid - Chemistryen_US
dc.subject.meshMaterials Testingen_US
dc.subject.meshOsteoblasts - Cytology - Metabolismen_US
dc.subject.meshPolymers - Chemistryen_US
dc.subject.meshViscosityen_US
dc.titleIn vitro behavior of osteoblast-like cells on PLLA films with a biomimetic apatite or apatite/collagen composite coatingen_US
dc.typeArticleen_US
dc.identifier.emailWang, M:memwang@hku.hken_US
dc.identifier.authorityWang, M=rp00185en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s10856-007-3335-8en_US
dc.identifier.pmid18058196-
dc.identifier.scopuseid_2-s2.0-41649103369en_US
dc.identifier.hkuros157729-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-41649103369&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume19en_US
dc.identifier.issue6en_US
dc.identifier.spage2261en_US
dc.identifier.epage2268en_US
dc.identifier.isiWOS:000254624600003-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChen, Y=8643007600en_US
dc.identifier.scopusauthoridMak, AFT=35516744100en_US
dc.identifier.scopusauthoridWang, M=15749714100en_US
dc.identifier.scopusauthoridLi, JS=7410064873en_US
dc.identifier.scopusauthoridWong, MS=23394345200en_US

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