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Article: An lower bound on receptor density for stable cell adhesion due to thermal undulations

TitleAn lower bound on receptor density for stable cell adhesion due to thermal undulations
Authors
Issue Date2007
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0022-2461
Citation
Journal Of Materials Science, 2007, v. 42 n. 21, p. 8904-8910 How to Cite?
AbstractThe adhesion of a living cell to an extracellular matrix surface is effected through the bonding of receptor molecules in the cell membrane to compatible ligand molecules on the surface. In a series of experiments on adhesion of cells to a substrate surface with a controlled density of ligand binding sites, Arnold et al. (ChemPhysChem 5:383, 2004) showed that tight cell adhesions could form only if the areal density of binding sites on the substrate was higher than some critical value. Furthermore, this critical value was consistent across the four cell types examined in the experiments. For ligand density below the critical level, on the other hand, virtually no adhesions formed. In this article, we examine the competition between thermal undulations of the cell membrane and its adhesion to the substrate. In particular, we show that thermal undulations destabilize membrane bonding to the substrate unless the bond spacing is below a certain level. By following this line of reasoning in the context of classical statistical mechanics, we obtain an estimate of the critical value of spacing which is in reasonable agreement with the observations. © 2007 Springer Science+Business Media, LLC.
Persistent Identifierhttp://hdl.handle.net/10722/156913
ISSN
2015 Impact Factor: 2.302
2015 SCImago Journal Rankings: 0.836
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLin, Yen_US
dc.contributor.authorFreund, LBen_US
dc.date.accessioned2012-08-08T08:44:31Z-
dc.date.available2012-08-08T08:44:31Z-
dc.date.issued2007en_US
dc.identifier.citationJournal Of Materials Science, 2007, v. 42 n. 21, p. 8904-8910en_US
dc.identifier.issn0022-2461en_US
dc.identifier.urihttp://hdl.handle.net/10722/156913-
dc.description.abstractThe adhesion of a living cell to an extracellular matrix surface is effected through the bonding of receptor molecules in the cell membrane to compatible ligand molecules on the surface. In a series of experiments on adhesion of cells to a substrate surface with a controlled density of ligand binding sites, Arnold et al. (ChemPhysChem 5:383, 2004) showed that tight cell adhesions could form only if the areal density of binding sites on the substrate was higher than some critical value. Furthermore, this critical value was consistent across the four cell types examined in the experiments. For ligand density below the critical level, on the other hand, virtually no adhesions formed. In this article, we examine the competition between thermal undulations of the cell membrane and its adhesion to the substrate. In particular, we show that thermal undulations destabilize membrane bonding to the substrate unless the bond spacing is below a certain level. By following this line of reasoning in the context of classical statistical mechanics, we obtain an estimate of the critical value of spacing which is in reasonable agreement with the observations. © 2007 Springer Science+Business Media, LLC.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0022-2461en_US
dc.relation.ispartofJournal of Materials Scienceen_US
dc.titleAn lower bound on receptor density for stable cell adhesion due to thermal undulationsen_US
dc.typeArticleen_US
dc.identifier.emailLin, Y:ylin@hku.hken_US
dc.identifier.authorityLin, Y=rp00080en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s10853-007-1720-9en_US
dc.identifier.scopuseid_2-s2.0-34548409622en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34548409622&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume42en_US
dc.identifier.issue21en_US
dc.identifier.spage8904en_US
dc.identifier.epage8910en_US
dc.identifier.isiWOS:000249213300015-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLin, Y=7406585339en_US
dc.identifier.scopusauthoridFreund, LB=7102315296en_US

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