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Article: Self-assembled collagen-human mesenchymal stem cell microspheres for regenerative medicine

TitleSelf-assembled collagen-human mesenchymal stem cell microspheres for regenerative medicine
Authors
KeywordsCell delivery
Collagen
Mesenchymal stem cell
Microencapsulation
Microspheres
Issue Date2007
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterials
Citation
Biomaterials, 2007, v. 28 n. 31, p. 4652-4666 How to Cite?
AbstractMesenchymal stem cells (MSCs)-based therapy is a promising approach in regenerative medicine and tissue engineering. However, the outcomes of existing treatments have not been satisfactory owing to suboptimal localization to implantation site, poor viability, low engraftment efficacy and lack of functional remodeling of the delivered cells. Therefore, adopting an effective cell delivery modality is among the biggest technological challenges for successful clinical applications of MSC-based therapy. We developed a novel microencapsulation technique producing self-assembled collagen-MSC microspheres and demonstrated that these microspheres could serve as excellent cell delivery devices as they were stable, injectable and able to provide a protective, growth- and migration-supporting matrix to MSCs. We also showed that MSCs could preserve their stem cell nature upon microencapsulation and easily be localized with retained viability upon in vivo implantation. These microspheres present novel cell delivery devices with optimal biological and functional profile that may facilitate clinical applications of MSC-based therapy. © 2007 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/156910
ISSN
2015 Impact Factor: 8.387
2015 SCImago Journal Rankings: 3.565
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, BPen_HK
dc.contributor.authorHui, TYen_HK
dc.contributor.authorYeung, CWen_HK
dc.contributor.authorLi, Jen_HK
dc.contributor.authorMo, Ien_HK
dc.contributor.authorChan, GCFen_HK
dc.date.accessioned2012-08-08T08:44:31Z-
dc.date.available2012-08-08T08:44:31Z-
dc.date.issued2007en_HK
dc.identifier.citationBiomaterials, 2007, v. 28 n. 31, p. 4652-4666en_HK
dc.identifier.issn0142-9612en_HK
dc.identifier.urihttp://hdl.handle.net/10722/156910-
dc.description.abstractMesenchymal stem cells (MSCs)-based therapy is a promising approach in regenerative medicine and tissue engineering. However, the outcomes of existing treatments have not been satisfactory owing to suboptimal localization to implantation site, poor viability, low engraftment efficacy and lack of functional remodeling of the delivered cells. Therefore, adopting an effective cell delivery modality is among the biggest technological challenges for successful clinical applications of MSC-based therapy. We developed a novel microencapsulation technique producing self-assembled collagen-MSC microspheres and demonstrated that these microspheres could serve as excellent cell delivery devices as they were stable, injectable and able to provide a protective, growth- and migration-supporting matrix to MSCs. We also showed that MSCs could preserve their stem cell nature upon microencapsulation and easily be localized with retained viability upon in vivo implantation. These microspheres present novel cell delivery devices with optimal biological and functional profile that may facilitate clinical applications of MSC-based therapy. © 2007 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterialsen_HK
dc.relation.ispartofBiomaterialsen_HK
dc.subjectCell deliveryen_HK
dc.subjectCollagenen_HK
dc.subjectMesenchymal stem cellen_HK
dc.subjectMicroencapsulationen_HK
dc.subjectMicrospheresen_HK
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshCell Culture Techniques - Methodsen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshCoated Materials, Biocompatible - Chemistryen_US
dc.subject.meshCollagen - Chemistryen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMesenchymal Stem Cell Transplantation - Methodsen_US
dc.subject.meshMesenchymal Stem Cells - Cytology - Physiologyen_US
dc.subject.meshMicrospheresen_US
dc.subject.meshRegenerative Medicine - Methodsen_US
dc.subject.meshTissue Engineering - Methodsen_US
dc.titleSelf-assembled collagen-human mesenchymal stem cell microspheres for regenerative medicineen_HK
dc.typeArticleen_HK
dc.identifier.emailChan, BP: bpchan@hkucc.hku.hken_HK
dc.identifier.emailLi, J: jamesli@hku.hken_HK
dc.identifier.emailChan, GCF: gcfchan@hku.hken_HK
dc.identifier.authorityChan, BP=rp00087en_HK
dc.identifier.authorityLi, J=rp00496en_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.biomaterials.2007.07.041en_HK
dc.identifier.pmid17681374-
dc.identifier.scopuseid_2-s2.0-34547892217en_HK
dc.identifier.hkuros137699-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34547892217&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue31en_HK
dc.identifier.spage4652en_HK
dc.identifier.epage4666en_HK
dc.identifier.eissn1878-5905-
dc.identifier.isiWOS:000249717500013-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridChan, BP=7201530390en_HK
dc.identifier.scopusauthoridHui, TY=36192803300en_HK
dc.identifier.scopusauthoridYeung, CW=18635690500en_HK
dc.identifier.scopusauthoridLi, J=23103447500en_HK
dc.identifier.scopusauthoridMo, I=25422283300en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK

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