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Article: Regular moderate exercise training prevents decrease of CD4 + T-lymphocytes induced by a single bout of strenuous exercise in mice

TitleRegular moderate exercise training prevents decrease of CD4 + T-lymphocytes induced by a single bout of strenuous exercise in mice
Authors
Issue Date2003
PublisherNational Research Council of Canada (N R C). The Journal's web site is located at http://apnm.nrc.ca
Citation
Canadian Journal Of Applied Physiology, 2003, v. 28 n. 3, p. 370-381 How to Cite?
AbstractThe biphasic effects of exercise training on the immune system have been studied extensively and represented by the well-known J-shaped curve with respect to training intensity. However, the relationship and interactions between "beneficial" exercise training and "harmful" strenuous exercise have not been researched. This study was designed to determine whether regular moderate exercise training could affect the changes of percentage of T-lymphocytes induced by a single bout of strenuous exercise. A protocol to run uphill on a 10° tilted treadmill for 4 weeks was employed as moderate exercise training in mice, while a sedentary control group of mice was exposed to the same handling stress without training. The trained and untrained mice were then exposed to a single bout of strenuous exercise until exhaustion. Total leukocytes were collected from spleen and peripheral blood at 0 hr, 3 hrs, and 24 hrs postexhaustion, as well as from the control groups. Flow cytometric analyses were conducted to determine the percentages of selected leukocyte populations. It was demonstrated that moderate exercise training prevented the decrease of CD4 + but stimulated the increase of CD25 +CD8 + T-lymphocytes induced by a single bout of strenuous exercise, indicating an adaptive response that can affect changes of leukocyte subpopuplations.
Persistent Identifierhttp://hdl.handle.net/10722/156682
ISSN
2007 Impact Factor: 1.302
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFu, SCen_US
dc.contributor.authorQin, Len_US
dc.contributor.authorLeung, CKen_US
dc.contributor.authorChan, BPen_US
dc.contributor.authorChan, KMen_US
dc.date.accessioned2012-08-08T08:43:30Z-
dc.date.available2012-08-08T08:43:30Z-
dc.date.issued2003en_US
dc.identifier.citationCanadian Journal Of Applied Physiology, 2003, v. 28 n. 3, p. 370-381en_US
dc.identifier.issn1066-7814en_US
dc.identifier.urihttp://hdl.handle.net/10722/156682-
dc.description.abstractThe biphasic effects of exercise training on the immune system have been studied extensively and represented by the well-known J-shaped curve with respect to training intensity. However, the relationship and interactions between "beneficial" exercise training and "harmful" strenuous exercise have not been researched. This study was designed to determine whether regular moderate exercise training could affect the changes of percentage of T-lymphocytes induced by a single bout of strenuous exercise. A protocol to run uphill on a 10° tilted treadmill for 4 weeks was employed as moderate exercise training in mice, while a sedentary control group of mice was exposed to the same handling stress without training. The trained and untrained mice were then exposed to a single bout of strenuous exercise until exhaustion. Total leukocytes were collected from spleen and peripheral blood at 0 hr, 3 hrs, and 24 hrs postexhaustion, as well as from the control groups. Flow cytometric analyses were conducted to determine the percentages of selected leukocyte populations. It was demonstrated that moderate exercise training prevented the decrease of CD4 + but stimulated the increase of CD25 +CD8 + T-lymphocytes induced by a single bout of strenuous exercise, indicating an adaptive response that can affect changes of leukocyte subpopuplations.en_US
dc.languageengen_US
dc.publisherNational Research Council of Canada (N R C). The Journal's web site is located at http://apnm.nrc.caen_US
dc.relation.ispartofCanadian Journal of Applied Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCd4 Lymphocyte Counten_US
dc.subject.meshCd4-Cd8 Ratioen_US
dc.subject.meshCd4-Positive T-Lymphocytes - Cytology - Immunologyen_US
dc.subject.meshCd8-Positive T-Lymphocytes - Cytology - Immunologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshLymphocyte Counten_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred Balb Cen_US
dc.subject.meshMotor Activity - Physiologyen_US
dc.subject.meshMultivariate Analysisen_US
dc.subject.meshPhysical Conditioning, Animal - Physiologyen_US
dc.subject.meshPhysical Endurance - Physiologyen_US
dc.subject.meshReceptors, Interleukin-2 - Analysisen_US
dc.subject.meshT-Lymphocytes - Cytologyen_US
dc.titleRegular moderate exercise training prevents decrease of CD4 + T-lymphocytes induced by a single bout of strenuous exercise in miceen_US
dc.typeArticleen_US
dc.identifier.emailChan, BP:bpchan@hkucc.hku.hken_US
dc.identifier.authorityChan, BP=rp00087en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid12955865-
dc.identifier.scopuseid_2-s2.0-0042883970en_US
dc.identifier.hkuros89221-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0042883970&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume28en_US
dc.identifier.issue3en_US
dc.identifier.spage370en_US
dc.identifier.epage381en_US
dc.identifier.isiWOS:000183580500004-
dc.publisher.placeCanadaen_US
dc.identifier.scopusauthoridFu, SC=7402732268en_US
dc.identifier.scopusauthoridQin, L=55245251000en_US
dc.identifier.scopusauthoridLeung, CK=36725512100en_US
dc.identifier.scopusauthoridChan, BP=7201530390en_US
dc.identifier.scopusauthoridChan, KM=7406034671en_US

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