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Article: In vitro evaluation of hydroxyapatite reinforced polyhydroxybutyrate composite

TitleIn vitro evaluation of hydroxyapatite reinforced polyhydroxybutyrate composite
Authors
KeywordsBioactivity
Biodegradation
Composite
Hydroxyapatite
In Vitro Behaviour
Polyhydroxybutyrate
Issue Date2002
PublisherElsevier SA. The Journal's web site is located at http://www.elsevier.com/locate/msec
Citation
Materials Science and Engineering C, 2002, v. 20 n. 1-2, p. 101-109 How to Cite?
AbstractParticulate hydroxyapatite (HA) was incorporated into polyhydroxybutyrate (PHB) to form a bioactive and biodegradable composite for applications in hard tissue replacement and regeneration. HA/PHB composite containing 10, 20, and 30 vol.% of HA was made for in vitro evaluation. In vitro studies were conducted using an acellular simulated body fluid (SBF). Composite specimens were immersed in SBF at 37 °C for various periods of time prior to surface analysis and mechanical testing. Results obtained from scanning electron microscopic (SEM) examination, thin film X-ray diffraction (TF-XRD) analysis, and Fourier transform infrared (FTIR) spectroscopy showed that a layer of bonelike apatite formed within a short period on HA/PHB composite after its immersion in SBF, demonstrating high in vitro bioactivity of the composite. The bioactivity and mechanical properties of the composite could be changed by varying the amount of HA in the composite. Dynamic mechanical analysis (DMA) revealed that the storage modulus (E) of HA/PHB composite increased initially with immersion time in SBF, due to apatite formation on composite surface and decreased after prolonged immersion in SBF, indicating degradation of the composite in a simulated body environment. HA/PHB composite thus has the potential for its intended applications. © 2002 Elsevier Science B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/156655
ISSN
2015 Impact Factor: 3.42
2015 SCImago Journal Rankings: 1.332
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNi, Jen_US
dc.contributor.authorWang, Men_US
dc.date.accessioned2012-08-08T08:43:24Z-
dc.date.available2012-08-08T08:43:24Z-
dc.date.issued2002en_US
dc.identifier.citationMaterials Science and Engineering C, 2002, v. 20 n. 1-2, p. 101-109en_US
dc.identifier.issn0928-4931en_US
dc.identifier.urihttp://hdl.handle.net/10722/156655-
dc.description.abstractParticulate hydroxyapatite (HA) was incorporated into polyhydroxybutyrate (PHB) to form a bioactive and biodegradable composite for applications in hard tissue replacement and regeneration. HA/PHB composite containing 10, 20, and 30 vol.% of HA was made for in vitro evaluation. In vitro studies were conducted using an acellular simulated body fluid (SBF). Composite specimens were immersed in SBF at 37 °C for various periods of time prior to surface analysis and mechanical testing. Results obtained from scanning electron microscopic (SEM) examination, thin film X-ray diffraction (TF-XRD) analysis, and Fourier transform infrared (FTIR) spectroscopy showed that a layer of bonelike apatite formed within a short period on HA/PHB composite after its immersion in SBF, demonstrating high in vitro bioactivity of the composite. The bioactivity and mechanical properties of the composite could be changed by varying the amount of HA in the composite. Dynamic mechanical analysis (DMA) revealed that the storage modulus (E) of HA/PHB composite increased initially with immersion time in SBF, due to apatite formation on composite surface and decreased after prolonged immersion in SBF, indicating degradation of the composite in a simulated body environment. HA/PHB composite thus has the potential for its intended applications. © 2002 Elsevier Science B.V. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier SA. The Journal's web site is located at http://www.elsevier.com/locate/msecen_US
dc.relation.ispartofMaterials Science and Engineering C: Biomimetic Materials, Sensors and Systemsen_US
dc.subjectBioactivityen_US
dc.subjectBiodegradationen_US
dc.subjectCompositeen_US
dc.subjectHydroxyapatiteen_US
dc.subjectIn Vitro Behaviouren_US
dc.subjectPolyhydroxybutyrateen_US
dc.titleIn vitro evaluation of hydroxyapatite reinforced polyhydroxybutyrate compositeen_US
dc.typeArticleen_US
dc.identifier.emailWang, M: memwang@hku.hken_US
dc.identifier.authorityWang, M=rp00185en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0928-4931(02)00019-Xen_US
dc.identifier.scopuseid_2-s2.0-0037205359en_US
dc.identifier.hkuros110856-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037205359&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume20en_US
dc.identifier.issue1-2en_US
dc.identifier.spage101en_US
dc.identifier.epage109en_US
dc.identifier.isiWOS:000176088200015-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridNi, J=8859102900en_US
dc.identifier.scopusauthoridWang, M=15749714100en_US

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