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Article: In vitro formation of bone-like apatite on the surface of solution-cast poorly crystallised hydroxyapatite/chitin composite

TitleIn vitro formation of bone-like apatite on the surface of solution-cast poorly crystallised hydroxyapatite/chitin composite
Authors
Issue Date2001
PublisherTrans Tech Publications Ltd. The Journal's web site is located at http://www.scientific.net
Citation
Key Engineering Materials, 2001, v. 192-195, p. 657-660 How to Cite?
AbstractPoorly crystallized hydroxyapatite (HA) particles were incorporated into chitin using the solution casting technique to produce a composite for potential medical applications. The optimised manufacturing condition resulted in ceramic particles being dispersed homogeneously in the composite. Composite plates having 10-60 wt% of the bioceramic were successfully produced. Plates of chitin and its composite were subsequently treated in a 5M NaOH solution at 60°C for 20 hours. In vitro mineralisation experiments were performed on as-cast and alkaline treated plates using simulated body fluid (SBF). It was shown that the poorly crystallized HA particles rendered the composite bioactive and improved the ability to induce the formation of bone-like apatite on material surfaces. An incubation temperature higher than 36.5°C accelerated the nucleation of bone-like apatite on the composite surface because of the dissolution of D-glucopyranose residues available which led to the increase in hydroxyl concentration in the vicinity of the surface. The alkaline treatment introduced more D-glucopyranose in chitin and hence significantly improved the in vitro nucleation of bone-like apatite on surfaces of chitin and its composite when they were immersed in SBF.
Persistent Identifierhttp://hdl.handle.net/10722/156582
ISSN
2005 Impact Factor: 0.224
2015 SCImago Journal Rankings: 0.173
References

 

DC FieldValueLanguage
dc.contributor.authorWeng, Jen_US
dc.contributor.authorWang, Men_US
dc.date.accessioned2012-08-08T08:43:04Z-
dc.date.available2012-08-08T08:43:04Z-
dc.date.issued2001en_US
dc.identifier.citationKey Engineering Materials, 2001, v. 192-195, p. 657-660en_US
dc.identifier.issn1013-9826en_US
dc.identifier.urihttp://hdl.handle.net/10722/156582-
dc.description.abstractPoorly crystallized hydroxyapatite (HA) particles were incorporated into chitin using the solution casting technique to produce a composite for potential medical applications. The optimised manufacturing condition resulted in ceramic particles being dispersed homogeneously in the composite. Composite plates having 10-60 wt% of the bioceramic were successfully produced. Plates of chitin and its composite were subsequently treated in a 5M NaOH solution at 60°C for 20 hours. In vitro mineralisation experiments were performed on as-cast and alkaline treated plates using simulated body fluid (SBF). It was shown that the poorly crystallized HA particles rendered the composite bioactive and improved the ability to induce the formation of bone-like apatite on material surfaces. An incubation temperature higher than 36.5°C accelerated the nucleation of bone-like apatite on the composite surface because of the dissolution of D-glucopyranose residues available which led to the increase in hydroxyl concentration in the vicinity of the surface. The alkaline treatment introduced more D-glucopyranose in chitin and hence significantly improved the in vitro nucleation of bone-like apatite on surfaces of chitin and its composite when they were immersed in SBF.en_US
dc.languageengen_US
dc.publisherTrans Tech Publications Ltd. The Journal's web site is located at http://www.scientific.neten_US
dc.relation.ispartofKey Engineering Materialsen_US
dc.titleIn vitro formation of bone-like apatite on the surface of solution-cast poorly crystallised hydroxyapatite/chitin compositeen_US
dc.typeArticleen_US
dc.identifier.emailWang, M:memwang@hku.hken_US
dc.identifier.authorityWang, M=rp00185en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-0035151486en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035151486&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume192-195en_US
dc.identifier.spage657en_US
dc.identifier.epage660en_US
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridWeng, J=7202292060en_US
dc.identifier.scopusauthoridWang, M=15749714100en_US

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