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Article: Increased cell proliferation and associated expression of PDGFRβ causing hypercellularity in patellar tendinosis

TitleIncreased cell proliferation and associated expression of PDGFRβ causing hypercellularity in patellar tendinosis
Authors
Issue Date2001
PublisherOxford University Press. The Journal's web site is located at http://rheumatology.oxfordjournals.org/
Citation
Rheumatology, 2001, v. 40 n. 3, p. 256-261 How to Cite?
AbstractObjective. This study assessed cellularity in patellar tendinosis with respect to cell proliferation and the expression of platelet-derived growth factor receptor β (PDGFRβ). Methods. Surgical samples were taken from 11 patients fulfilling criteria of patellar tendinosis and from 12 matched controls. Standard immunohistochemistry methods were used to detect expression of PDGFRβ and proliferation cell nuclear antigen (PCNA). Results were analysed by computer-assisted microscopy. Tendon cells were isolated from nine tendinosis and eight control tissues for cell culture. Results. Increased cellularity (P<0.001) was observed in tendinosis tissues compared with controls, and also a higher proliferative index (P<0.001). Increased expression of PDGFRβ was demonstrated (P<0.001). Cultured tendinosis cells showed a higher proliferation rate than controls (P<0.001). This was maintained when the cells were cultured under various conditions of serum supplementation (P<0.01). Tendinosis cells also showed a higher proliferation rate (P<0.01) in medium containing 10 ng/ml PDGF. Conclusion. Hypercellularity in patellar tendinosis is caused by increased cell proliferation and is associated with increased expression of PDGFRβ.
Persistent Identifierhttp://hdl.handle.net/10722/156577
ISSN
2015 Impact Factor: 4.524
2015 SCImago Journal Rankings: 1.449
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorRolf, CGen_US
dc.contributor.authorFu, BSCen_US
dc.contributor.authorPau, Aen_US
dc.contributor.authorWang, Wen_US
dc.contributor.authorChan, Ben_US
dc.date.accessioned2012-08-08T08:43:03Z-
dc.date.available2012-08-08T08:43:03Z-
dc.date.issued2001en_US
dc.identifier.citationRheumatology, 2001, v. 40 n. 3, p. 256-261en_US
dc.identifier.issn1462-0324en_US
dc.identifier.urihttp://hdl.handle.net/10722/156577-
dc.description.abstractObjective. This study assessed cellularity in patellar tendinosis with respect to cell proliferation and the expression of platelet-derived growth factor receptor β (PDGFRβ). Methods. Surgical samples were taken from 11 patients fulfilling criteria of patellar tendinosis and from 12 matched controls. Standard immunohistochemistry methods were used to detect expression of PDGFRβ and proliferation cell nuclear antigen (PCNA). Results were analysed by computer-assisted microscopy. Tendon cells were isolated from nine tendinosis and eight control tissues for cell culture. Results. Increased cellularity (P<0.001) was observed in tendinosis tissues compared with controls, and also a higher proliferative index (P<0.001). Increased expression of PDGFRβ was demonstrated (P<0.001). Cultured tendinosis cells showed a higher proliferation rate than controls (P<0.001). This was maintained when the cells were cultured under various conditions of serum supplementation (P<0.01). Tendinosis cells also showed a higher proliferation rate (P<0.01) in medium containing 10 ng/ml PDGF. Conclusion. Hypercellularity in patellar tendinosis is caused by increased cell proliferation and is associated with increased expression of PDGFRβ.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://rheumatology.oxfordjournals.org/en_US
dc.relation.ispartofRheumatologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshCell Division - Physiologyen_US
dc.subject.meshCells, Cultured - Metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHyperplasia - Metabolism - Pathology - Physiopathologyen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshMaleen_US
dc.subject.meshPatellar Ligament - Metabolism - Pathology - Physiopathologyen_US
dc.subject.meshPlatelet-Derived Growth Factor - Metabolismen_US
dc.subject.meshProliferating Cell Nuclear Antigen - Metabolismen_US
dc.subject.meshReceptor, Platelet-Derived Growth Factor Beta - Metabolismen_US
dc.subject.meshTendinopathy - Metabolism - Pathology - Physiopathologyen_US
dc.titleIncreased cell proliferation and associated expression of PDGFRβ causing hypercellularity in patellar tendinosisen_US
dc.typeArticleen_US
dc.identifier.emailChan, B:bpchan@hkucc.hku.hken_US
dc.identifier.authorityChan, B=rp00087en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid11285371-
dc.identifier.scopuseid_2-s2.0-0035060633en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035060633&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume40en_US
dc.identifier.issue3en_US
dc.identifier.spage256en_US
dc.identifier.epage261en_US
dc.identifier.isiWOS:000167965200003-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridRolf, CG=8558587900en_US
dc.identifier.scopusauthoridFu, BSC=7402732268en_US
dc.identifier.scopusauthoridPau, A=7004284279en_US
dc.identifier.scopusauthoridWang, W=38262127700en_US
dc.identifier.scopusauthoridChan, B=7201530390en_US

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