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Article: Effects of basic fibroblast growth factor (bFGF) on early stages of tendon healing. A rat patellar tendon model

TitleEffects of basic fibroblast growth factor (bFGF) on early stages of tendon healing. A rat patellar tendon model
Authors
Issue Date2000
Citation
Acta Orthopaedica Scandinavica, 2000, v. 71 n. 5, p. 513-518 How to Cite?
AbstractWe studied the effects of basic fibroblast growth factor (bFGF) on cell proliferation, type III collagen expression, ultimate stress and the pyridinoline content in the early stages of healing in rat patellar tendon. 96 male Sprague Dawley rats were injected with increasing doses of basic fibroblast growth factor (bFGF) at 3 days after a 'window defect' was induced in the mid-part of the patellar tendon. They were killed at 7 and 14 days after the injury. A dose-dependent increase in the number of proliferating cells and the level of expression of type III collagen was demonstrated at only 7 days post-injury. On the other hand, we found no effects of bFGF on ultimate stress and the pyridinoline content of healing tendons. Only time significantly affected both strength-associated parameters. We showed that in vivo supplementation with bFGF affected the initial events of healing such as cell proliferation and type III collagen expression.
Persistent Identifierhttp://hdl.handle.net/10722/156542
ISSN
2004 Impact Factor: 1.018
2008 SCImago Journal Rankings: 1.909
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, BPen_US
dc.contributor.authorFu, SCen_US
dc.contributor.authorQin, Len_US
dc.contributor.authorLee, KMen_US
dc.contributor.authorRolf, CGen_US
dc.contributor.authorChan, KMen_US
dc.date.accessioned2012-08-08T08:42:52Z-
dc.date.available2012-08-08T08:42:52Z-
dc.date.issued2000en_US
dc.identifier.citationActa Orthopaedica Scandinavica, 2000, v. 71 n. 5, p. 513-518en_US
dc.identifier.issn0001-6470en_US
dc.identifier.urihttp://hdl.handle.net/10722/156542-
dc.description.abstractWe studied the effects of basic fibroblast growth factor (bFGF) on cell proliferation, type III collagen expression, ultimate stress and the pyridinoline content in the early stages of healing in rat patellar tendon. 96 male Sprague Dawley rats were injected with increasing doses of basic fibroblast growth factor (bFGF) at 3 days after a 'window defect' was induced in the mid-part of the patellar tendon. They were killed at 7 and 14 days after the injury. A dose-dependent increase in the number of proliferating cells and the level of expression of type III collagen was demonstrated at only 7 days post-injury. On the other hand, we found no effects of bFGF on ultimate stress and the pyridinoline content of healing tendons. Only time significantly affected both strength-associated parameters. We showed that in vivo supplementation with bFGF affected the initial events of healing such as cell proliferation and type III collagen expression.en_US
dc.languageengen_US
dc.relation.ispartofActa Orthopaedica Scandinavicaen_US
dc.subject.meshAmino Acids - Analysisen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Divisionen_US
dc.subject.meshCollagen - Metabolismen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshFibroblast Growth Factor 2 - Pharmacologyen_US
dc.subject.meshFibroblasts - Physiologyen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshMaleen_US
dc.subject.meshPatella - Metabolismen_US
dc.subject.meshRandom Allocationen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshTendon Injuries - Metabolism - Physiopathologyen_US
dc.subject.meshWound Healing - Drug Effects - Physiologyen_US
dc.titleEffects of basic fibroblast growth factor (bFGF) on early stages of tendon healing. A rat patellar tendon modelen_US
dc.typeArticleen_US
dc.identifier.emailChan, BP:bpchan@hkucc.hku.hken_US
dc.identifier.authorityChan, BP=rp00087en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid11186411-
dc.identifier.scopuseid_2-s2.0-0033766526en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033766526&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume71en_US
dc.identifier.issue5en_US
dc.identifier.spage513en_US
dc.identifier.epage518en_US
dc.identifier.isiWOS:000165329900016-
dc.identifier.scopusauthoridChan, BP=7201530390en_US
dc.identifier.scopusauthoridFu, SC=7402732268en_US
dc.identifier.scopusauthoridQin, L=24449633900en_US
dc.identifier.scopusauthoridLee, KM=7501496900en_US
dc.identifier.scopusauthoridRolf, CG=8558587900en_US
dc.identifier.scopusauthoridChan, KM=7406034671en_US

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