File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Effects of scan circle displacement in optical coherence tomography retinal nerve fibre layer thickness measurement: A RNFL modelling study

TitleEffects of scan circle displacement in optical coherence tomography retinal nerve fibre layer thickness measurement: A RNFL modelling study
Authors
Issue Date2009
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/eye
Citation
Eye, 2009, v. 23 n. 6, p. 1436-1441 How to Cite?
AbstractObjective: To study the effect of optical coherence tomography (OCT) scan circle displacement on retinal nerve fibre layer (RNFL) measurement errors using cubic spline models.MethodsForty-nine normal subjects were included in the analysis. In one randomly selected eye in each subject, RNFL thickness around the optic disc was measured by taking 16 circular scans of different sizes (scan radius ranged from 1 to 2.5 mm). The RNFL profile in each eye was constructed with a mathematical model using a smoothing spline approximation. Scan circle (diameter 3.4 mm) RNFL measurements (total average, superior, nasal, inferior, and temporal RNFL thicknesses) obtained from eight directions (superior, superonasal, nasal, inferonasal, inferior, inferotemporal, temporal, and superotemporal) displaced at different distances (0.1, 0.2, 0.3, 0.4, 0.5, 0.6, and 0.7 mm) from the disc centre were then computed by a computer program and compared to the reference standard where the scan circle is centred at the optic disc. RNFL measurement error was calculated as the absolute of (RNFL thickness (displaced) - RNFL thickness (reference standard)).ResultsThe respective mean average, superior, nasal, inferior, and temporal RNFL measurement errors were 2.32.0, 4.94.5, 4.13.8, 6.27.6, and 3.83.5 m upon 0.1 mm scan circle displacement, and 12.111.4, 27.818.4, 21.718.6, 34.822.9, and 15.210.7 m upon 0.7 mm scan circle displacement. Significant differences of average and quadrant RNFL thicknesses were evident between centred and displaced scan circle measurements (all with P0.001). RNFL measurement error increased in a monotonic fashion with increasing distance away from the disc and the change was direction-dependent.ConclusionsRNFL measurement error varies with the direction and distance of scan displacement. The superior and the inferior RNFL measurements are most vulnerable to scan displacement errors, whereas the average RNFL thickness is the least susceptible. Obtaining a well-centred scan is essential for reliable RNFL measurement in OCT. © 2009 Macmillan Publishers Limited All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/155918
ISSN
2015 Impact Factor: 2.213
2015 SCImago Journal Rankings: 1.132
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, CYLen_US
dc.contributor.authorYiu, CKFen_US
dc.contributor.authorWeinreb, RNen_US
dc.contributor.authorLin, Den_US
dc.contributor.authorLi, Hen_US
dc.contributor.authorYung, AYen_US
dc.contributor.authorPang, CPen_US
dc.contributor.authorLam, DSCen_US
dc.contributor.authorLeung, CKSen_US
dc.date.accessioned2012-08-08T08:38:24Z-
dc.date.available2012-08-08T08:38:24Z-
dc.date.issued2009en_US
dc.identifier.citationEye, 2009, v. 23 n. 6, p. 1436-1441en_US
dc.identifier.issn0950-222Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/155918-
dc.description.abstractObjective: To study the effect of optical coherence tomography (OCT) scan circle displacement on retinal nerve fibre layer (RNFL) measurement errors using cubic spline models.MethodsForty-nine normal subjects were included in the analysis. In one randomly selected eye in each subject, RNFL thickness around the optic disc was measured by taking 16 circular scans of different sizes (scan radius ranged from 1 to 2.5 mm). The RNFL profile in each eye was constructed with a mathematical model using a smoothing spline approximation. Scan circle (diameter 3.4 mm) RNFL measurements (total average, superior, nasal, inferior, and temporal RNFL thicknesses) obtained from eight directions (superior, superonasal, nasal, inferonasal, inferior, inferotemporal, temporal, and superotemporal) displaced at different distances (0.1, 0.2, 0.3, 0.4, 0.5, 0.6, and 0.7 mm) from the disc centre were then computed by a computer program and compared to the reference standard where the scan circle is centred at the optic disc. RNFL measurement error was calculated as the absolute of (RNFL thickness (displaced) - RNFL thickness (reference standard)).ResultsThe respective mean average, superior, nasal, inferior, and temporal RNFL measurement errors were 2.32.0, 4.94.5, 4.13.8, 6.27.6, and 3.83.5 m upon 0.1 mm scan circle displacement, and 12.111.4, 27.818.4, 21.718.6, 34.822.9, and 15.210.7 m upon 0.7 mm scan circle displacement. Significant differences of average and quadrant RNFL thicknesses were evident between centred and displaced scan circle measurements (all with P0.001). RNFL measurement error increased in a monotonic fashion with increasing distance away from the disc and the change was direction-dependent.ConclusionsRNFL measurement error varies with the direction and distance of scan displacement. The superior and the inferior RNFL measurements are most vulnerable to scan displacement errors, whereas the average RNFL thickness is the least susceptible. Obtaining a well-centred scan is essential for reliable RNFL measurement in OCT. © 2009 Macmillan Publishers Limited All rights reserved.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/eyeen_US
dc.relation.ispartofEyeen_US
dc.subject.meshAdulten_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImaging, Three-Dimensional - Methodsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshModels, Biologicalen_US
dc.subject.meshNerve Fibersen_US
dc.subject.meshOptic Disk - Anatomy & Histologyen_US
dc.subject.meshRetinal Ganglion Cells - Cytologyen_US
dc.subject.meshTomography, Optical Coherenceen_US
dc.subject.meshYoung Adulten_US
dc.titleEffects of scan circle displacement in optical coherence tomography retinal nerve fibre layer thickness measurement: A RNFL modelling studyen_US
dc.typeArticleen_US
dc.identifier.emailYiu, CKF:cedric@hkucc.hku.hken_US
dc.identifier.authorityYiu, CKF=rp00206en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/eye.2008.258en_US
dc.identifier.pmid18806767-
dc.identifier.scopuseid_2-s2.0-67650662236en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67650662236&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume23en_US
dc.identifier.issue6en_US
dc.identifier.spage1436en_US
dc.identifier.epage1441en_US
dc.identifier.isiWOS:000266900500031-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridCheung, CYL=7202061791en_US
dc.identifier.scopusauthoridYiu, CKF=24802813000en_US
dc.identifier.scopusauthoridWeinreb, RN=35380128600en_US
dc.identifier.scopusauthoridLin, D=19337452400en_US
dc.identifier.scopusauthoridLi, H=25958185900en_US
dc.identifier.scopusauthoridYung, AY=26644627600en_US
dc.identifier.scopusauthoridPang, CP=24423687500en_US
dc.identifier.scopusauthoridLam, DSC=35500200200en_US
dc.identifier.scopusauthoridLeung, CKS=8834590400en_US
dc.identifier.citeulike3292822-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats