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Article: Dynamic analysis of dark-light changes of the anterior chamber angle with anterior segment OCT

TitleDynamic analysis of dark-light changes of the anterior chamber angle with anterior segment OCT
Authors
Issue Date2007
PublisherAssociation for Research in Vision and Ophthalmology. The Journal's web site is located at http://www.iovs.org
Citation
Investigative Ophthalmology And Visual Science, 2007, v. 48 n. 9, p. 4116-4122 How to Cite?
AbstractPURPOSE. To describe the use of anterior segment optical coherence tomography (OCT) in studying the dynamic dark-light changes of the anterior chamber angle. METHODS. Thirty-seven normal subjects with open angles on dark-room gonioscopy and 18 subjects with narrow angles were analyzed. The dynamic dark-light changes of the anterior-chamber angle were captured with real-time video recording. The angle opening distance (AOD500) and trabecular iris space area (TISA500) of the nasal angle and the pupil diameter in each of the representative serial images were measured. Linear regression analysis was performed to investigate the association between AOD500/TISA500 and pupil diameter. Demographic and biometry measurements associated with the AOD difference (AOD500 (light) - AOD500 (dark)) and TISA difference (TISA500 (light) - TISA500 (dark)) were analyzed with univariate and multivariate regression models. RESULTS. The AOD500/TLSA500 measured in the light in the open-angle and the narrow-angle groups were 694 ± 330 μm/0.24 ± 0.10 mm 2 and 265 ±78 μm/0.10 ± 0.03 mm 2, respectively. These values were significantly greater than the AOD500/TISA500 measured in the dark (492 ± 265 μm/0.16 ± 0.08 mm 2 and 119 ± 82 μm/0.05 ± 0.04 mm 2, respectively, all with P < 0.001). The ranges of the AOD/TISA difference were 13 to 817 μm/0.011 to 0.154 mm 2, with an average of 180 μm/0.073 mm 2. Multivariate regression analysis identified a positive correlation between anterior chamber depth and the AOD/TISA difference. Fifty eyes showed significant correlations between AOD/TISA and pupil diameter, whereas one eye showed no association. Four eyes in the narrow angle group developed appositional angle closure in the dark. CONCLUSIONS. The dynamic dark-light changes of the anterior chamber angle can be imaged and analyzed with anterior segment OCT. Although the angle width generally decreased linearly with increasing pupil diameter, the differences of the angle width measured in the dark and in the light varied substantially among individuals. Copyright © Association for Research in Vision and Ophthalmology.
Persistent Identifierhttp://hdl.handle.net/10722/155902
ISSN
2015 Impact Factor: 3.427
2015 SCImago Journal Rankings: 2.008
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, CKSen_US
dc.contributor.authorCheung, CYLen_US
dc.contributor.authorLi, Hen_US
dc.contributor.authorDorairaj, Sen_US
dc.contributor.authorYiu, CKFen_US
dc.contributor.authorWong, ALen_US
dc.contributor.authorLiebmann, Jen_US
dc.contributor.authorRitch, Ren_US
dc.contributor.authorWeinreb, Ren_US
dc.contributor.authorLam, DSCen_US
dc.date.accessioned2012-08-08T08:38:18Z-
dc.date.available2012-08-08T08:38:18Z-
dc.date.issued2007en_US
dc.identifier.citationInvestigative Ophthalmology And Visual Science, 2007, v. 48 n. 9, p. 4116-4122en_US
dc.identifier.issn0146-0404en_US
dc.identifier.urihttp://hdl.handle.net/10722/155902-
dc.description.abstractPURPOSE. To describe the use of anterior segment optical coherence tomography (OCT) in studying the dynamic dark-light changes of the anterior chamber angle. METHODS. Thirty-seven normal subjects with open angles on dark-room gonioscopy and 18 subjects with narrow angles were analyzed. The dynamic dark-light changes of the anterior-chamber angle were captured with real-time video recording. The angle opening distance (AOD500) and trabecular iris space area (TISA500) of the nasal angle and the pupil diameter in each of the representative serial images were measured. Linear regression analysis was performed to investigate the association between AOD500/TISA500 and pupil diameter. Demographic and biometry measurements associated with the AOD difference (AOD500 (light) - AOD500 (dark)) and TISA difference (TISA500 (light) - TISA500 (dark)) were analyzed with univariate and multivariate regression models. RESULTS. The AOD500/TLSA500 measured in the light in the open-angle and the narrow-angle groups were 694 ± 330 μm/0.24 ± 0.10 mm 2 and 265 ±78 μm/0.10 ± 0.03 mm 2, respectively. These values were significantly greater than the AOD500/TISA500 measured in the dark (492 ± 265 μm/0.16 ± 0.08 mm 2 and 119 ± 82 μm/0.05 ± 0.04 mm 2, respectively, all with P < 0.001). The ranges of the AOD/TISA difference were 13 to 817 μm/0.011 to 0.154 mm 2, with an average of 180 μm/0.073 mm 2. Multivariate regression analysis identified a positive correlation between anterior chamber depth and the AOD/TISA difference. Fifty eyes showed significant correlations between AOD/TISA and pupil diameter, whereas one eye showed no association. Four eyes in the narrow angle group developed appositional angle closure in the dark. CONCLUSIONS. The dynamic dark-light changes of the anterior chamber angle can be imaged and analyzed with anterior segment OCT. Although the angle width generally decreased linearly with increasing pupil diameter, the differences of the angle width measured in the dark and in the light varied substantially among individuals. Copyright © Association for Research in Vision and Ophthalmology.en_US
dc.languageengen_US
dc.publisherAssociation for Research in Vision and Ophthalmology. The Journal's web site is located at http://www.iovs.orgen_US
dc.relation.ispartofInvestigative Ophthalmology and Visual Scienceen_US
dc.titleDynamic analysis of dark-light changes of the anterior chamber angle with anterior segment OCTen_US
dc.typeArticleen_US
dc.identifier.emailYiu, CKF:cedric@hkucc.hku.hken_US
dc.identifier.authorityYiu, CKF=rp00206en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1167/iovs.07-0010en_US
dc.identifier.scopuseid_2-s2.0-35148850981en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-35148850981&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume48en_US
dc.identifier.issue9en_US
dc.identifier.spage4116en_US
dc.identifier.epage4122en_US
dc.identifier.isiWOS:000249061900030-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLeung, CKS=8834590400en_US
dc.identifier.scopusauthoridCheung, CYL=7202061791en_US
dc.identifier.scopusauthoridLi, H=25958185900en_US
dc.identifier.scopusauthoridDorairaj, S=15062315100en_US
dc.identifier.scopusauthoridYiu, CKF=24802813000en_US
dc.identifier.scopusauthoridWong, AL=36921625300en_US
dc.identifier.scopusauthoridLiebmann, J=7102904577en_US
dc.identifier.scopusauthoridRitch, R=35374631600en_US
dc.identifier.scopusauthoridWeinreb, R=35380128600en_US
dc.identifier.scopusauthoridLam, DSC=35500200200en_US

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