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Article: High-resolution MR imaging of mouse brain microvasculature using the relaxation rate shift index Q

TitleHigh-resolution MR imaging of mouse brain microvasculature using the relaxation rate shift index Q
Authors
Issue Date2004
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/13087
Citation
Nmr In Biomedicine, 2004, v. 17 n. 7, p. 507-512 How to Cite?
AbstractMagnetic resonance imaging (MRI) is a powerful method for in vivo quantification of tissue properfies. It has been previously proposed that the index Q ≡ ΔR 2/(ΔR*2 2/3, where ΔR 2 and ΔR 2* are the spin echo and gradient echo relaxation rate shifts caused by the injection of an intravascular contrast agent, may be useful for characterizing microvasculature. In particular, Q is expected to correlate well with the density of microvessels. This study presents high-resolution in vivo Q-maps of normal mouse brain obtained with a superparamagnetic iron oxide contrast agent at a field of level of 9.4 T. Normative Q values are derived for several regions of interest and significant interregional variations are observed. Microvessel densities estimated from the Q-maps are found to be in reasonable accord with histologically determined values. A possible application of Q-maps is the assessment of angiogenic activity in tumors. Copyright © 2004 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/155774
ISSN
2015 Impact Factor: 2.983
2015 SCImago Journal Rankings: 1.533
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWu, EXen_US
dc.contributor.authorTang, Hen_US
dc.contributor.authorJensen, JHen_US
dc.date.accessioned2012-08-08T08:35:17Z-
dc.date.available2012-08-08T08:35:17Z-
dc.date.issued2004en_US
dc.identifier.citationNmr In Biomedicine, 2004, v. 17 n. 7, p. 507-512en_US
dc.identifier.issn0952-3480en_US
dc.identifier.urihttp://hdl.handle.net/10722/155774-
dc.description.abstractMagnetic resonance imaging (MRI) is a powerful method for in vivo quantification of tissue properfies. It has been previously proposed that the index Q ≡ ΔR 2/(ΔR*2 2/3, where ΔR 2 and ΔR 2* are the spin echo and gradient echo relaxation rate shifts caused by the injection of an intravascular contrast agent, may be useful for characterizing microvasculature. In particular, Q is expected to correlate well with the density of microvessels. This study presents high-resolution in vivo Q-maps of normal mouse brain obtained with a superparamagnetic iron oxide contrast agent at a field of level of 9.4 T. Normative Q values are derived for several regions of interest and significant interregional variations are observed. Microvessel densities estimated from the Q-maps are found to be in reasonable accord with histologically determined values. A possible application of Q-maps is the assessment of angiogenic activity in tumors. Copyright © 2004 John Wiley & Sons, Ltd.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/13087en_US
dc.relation.ispartofNMR in Biomedicineen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBrain - Anatomy & Histology - Blood Supplyen_US
dc.subject.meshCerebrovascular Circulationen_US
dc.subject.meshContrast Mediaen_US
dc.subject.meshFerric Compounds - Diagnostic Useen_US
dc.subject.meshImage Enhancement - Methodsen_US
dc.subject.meshImage Interpretation, Computer-Assisted - Methodsen_US
dc.subject.meshMagnetic Resonance Imaging - Methodsen_US
dc.subject.meshMiceen_US
dc.subject.meshMicrocirculation - Anatomy & Histologyen_US
dc.titleHigh-resolution MR imaging of mouse brain microvasculature using the relaxation rate shift index Qen_US
dc.typeArticleen_US
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_US
dc.identifier.authorityWu, EX=rp00193en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/nbm.921en_US
dc.identifier.pmid15523704en_US
dc.identifier.scopuseid_2-s2.0-9244252480en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-9244252480&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume17en_US
dc.identifier.issue7en_US
dc.identifier.spage507en_US
dc.identifier.epage512en_US
dc.identifier.isiWOS:000225332500010-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridWu, EX=7202128034en_US
dc.identifier.scopusauthoridTang, H=36827331000en_US
dc.identifier.scopusauthoridJensen, JH=7404521984en_US
dc.identifier.citeulike4210869-

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