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Article: Applications of ultrasmall superparamagnetic iron oxide contrast agents in the MR study of animal models

TitleApplications of ultrasmall superparamagnetic iron oxide contrast agents in the MR study of animal models
Authors
Issue Date2004
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/13087
Citation
Nmr In Biomedicine, 2004, v. 17 n. 7, p. 478-483 How to Cite?
AbstractUltrasmall superparamagnetic iron oxide nanoparticles have been widely used during the past decade as MR intravascular contrast agents in the study of animal models. Such agents enhance both T 1 and T 2/T 2* relaxation, although for animal studies it is the later type of enhancement that is most commonly exploited. Their strong microscopic intravascular susceptibility effect enables the local blood volume distribution to be mapped in various organs. High spatial resolution and sensitivity can be achieved, because the long half-life of these agents in blood, combined with anesthetization, permits steady-state measurements over extended periods. This capability has been utilized to study the cerebrovascular blood volume distributions and their changes in normal, activated, pathologic and pharmacologically or genetically modified states, particularly in rodent animal models. It has also been applied to study blood volume changes in other tissues, such as the myocardium. The relaxation rate shifts ΔR 2 and ΔR 2* induced by iron oxide agents may differ depending on certain morphological characteristics of the microvascular network, and sensitive ΔR 2 and ΔR 2* mapping can potentially provide, in addition to blood volume, measurement of other important microvascular parameters such as blood vessel density and size. This work aims to review the applications of ultrasmall superparamagnetic iron oxide contrast agents in MR animal studies, with an emphasis on the investigation of microvascular parameters. Copyright © 2004 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/155773
ISSN
2015 Impact Factor: 2.983
2015 SCImago Journal Rankings: 1.533
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWu, EXen_US
dc.contributor.authorTang, Hen_US
dc.contributor.authorJensen, JHen_US
dc.date.accessioned2012-08-08T08:35:17Z-
dc.date.available2012-08-08T08:35:17Z-
dc.date.issued2004en_US
dc.identifier.citationNmr In Biomedicine, 2004, v. 17 n. 7, p. 478-483en_US
dc.identifier.issn0952-3480en_US
dc.identifier.urihttp://hdl.handle.net/10722/155773-
dc.description.abstractUltrasmall superparamagnetic iron oxide nanoparticles have been widely used during the past decade as MR intravascular contrast agents in the study of animal models. Such agents enhance both T 1 and T 2/T 2* relaxation, although for animal studies it is the later type of enhancement that is most commonly exploited. Their strong microscopic intravascular susceptibility effect enables the local blood volume distribution to be mapped in various organs. High spatial resolution and sensitivity can be achieved, because the long half-life of these agents in blood, combined with anesthetization, permits steady-state measurements over extended periods. This capability has been utilized to study the cerebrovascular blood volume distributions and their changes in normal, activated, pathologic and pharmacologically or genetically modified states, particularly in rodent animal models. It has also been applied to study blood volume changes in other tissues, such as the myocardium. The relaxation rate shifts ΔR 2 and ΔR 2* induced by iron oxide agents may differ depending on certain morphological characteristics of the microvascular network, and sensitive ΔR 2 and ΔR 2* mapping can potentially provide, in addition to blood volume, measurement of other important microvascular parameters such as blood vessel density and size. This work aims to review the applications of ultrasmall superparamagnetic iron oxide contrast agents in MR animal studies, with an emphasis on the investigation of microvascular parameters. Copyright © 2004 John Wiley & Sons, Ltd.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/13087en_US
dc.relation.ispartofNMR in Biomedicineen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Flow Velocity - Physiologyen_US
dc.subject.meshContrast Mediaen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshFerric Compounds - Diagnostic Useen_US
dc.subject.meshHumansen_US
dc.subject.meshImage Enhancement - Methodsen_US
dc.subject.meshMagnetic Resonance Imaging - Methodsen_US
dc.subject.meshMicrocirculation - Anatomy & Histology - Physiologyen_US
dc.subject.meshMicrospheresen_US
dc.subject.meshModels, Animalen_US
dc.subject.meshParticle Sizeen_US
dc.titleApplications of ultrasmall superparamagnetic iron oxide contrast agents in the MR study of animal modelsen_US
dc.typeArticleen_US
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_US
dc.identifier.authorityWu, EX=rp00193en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/nbm.923en_US
dc.identifier.pmid15526349-
dc.identifier.scopuseid_2-s2.0-9244232783en_US
dc.identifier.hkuros109188-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-9244232783&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume17en_US
dc.identifier.issue7en_US
dc.identifier.spage478en_US
dc.identifier.epage483en_US
dc.identifier.isiWOS:000225332500007-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridWu, EX=7202128034en_US
dc.identifier.scopusauthoridTang, H=36827331000en_US
dc.identifier.scopusauthoridJensen, JH=7404521984en_US

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