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Article: Balanced steady-state free precession fMRI with intravascular susceptibility contrast agent
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TitleBalanced steady-state free precession fMRI with intravascular susceptibility contrast agent
 
AuthorsZhou, IY1
Cheung, MM1
Lau, C1
Chan, KC1
Wu, EX1
 
KeywordsbSSFP
CBV
fMRI
Intravascular susceptibility contrast agent
MION
Rat
 
Issue Date2012
 
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0740-3194/
 
CitationMagnetic Resonance In Medicine, 2012, v. 68 n. 1, p. 65-73 [How to Cite?]
DOI: http://dx.doi.org/10.1002/mrm.23202
 
AbstractOne major challenge in echo planar imaging-based functional MRI (fMRI) is the susceptibility-induced image distortion. In this study, a new cerebral blood volume-weighted fMRI technique using distortion-free balanced steady-state free precession (bSSFP) sequence was proposed and its feasibility was investigated in rat brain at 7 Tesla. After administration of intravascular susceptibility contrast agent (monocrystalline iron oxide nanoparticle [MION] at 15 mg/kg), unilateral visual stimulation was presented using a block-design paradigm. With repetition time/echo time = 3.8/1.9 ms and α = 18°, bSSFP fMRI was performed and compared with the conventional cerebral blood volume-weighted fMRI using post-MION gradient echo and spin echo echo planar imaging. The results showed that post-MION bSSFP fMRI provides comparable sensitivity but with no severe image distortion and signal dropout. Robust negative responses were observed during stimulation and activation patterns were in excellent agreement with known neuroanatomy. Furthermore, the post-MION bSSFP signal was observed to decrease significantly during hypercapnia challenge, indicating its sensitivity to cerebral blood volume changes. These findings demonstrated that post-MION bSSFP fMRI is a promising alternative to conventional cerebral blood volume-weighted fMRI. This technique is particularly suited for fMRI investigation of animal models at high field. © 2011 Wiley Periodicals, Inc.
 
ISSN0740-3194
2013 Impact Factor: 3.398
 
DOIhttp://dx.doi.org/10.1002/mrm.23202
 
ISI Accession Number IDWOS:000305119100007
Funding AgencyGrant Number
Hong Kong Research Grant CouncilHKU7826/10M
Funding Information:

Grant sponsor: Hong Kong Research Grant Council; Grant number: HKU7826/10M.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorZhou, IY
 
dc.contributor.authorCheung, MM
 
dc.contributor.authorLau, C
 
dc.contributor.authorChan, KC
 
dc.contributor.authorWu, EX
 
dc.date.accessioned2012-08-08T08:35:16Z
 
dc.date.available2012-08-08T08:35:16Z
 
dc.date.issued2012
 
dc.description.abstractOne major challenge in echo planar imaging-based functional MRI (fMRI) is the susceptibility-induced image distortion. In this study, a new cerebral blood volume-weighted fMRI technique using distortion-free balanced steady-state free precession (bSSFP) sequence was proposed and its feasibility was investigated in rat brain at 7 Tesla. After administration of intravascular susceptibility contrast agent (monocrystalline iron oxide nanoparticle [MION] at 15 mg/kg), unilateral visual stimulation was presented using a block-design paradigm. With repetition time/echo time = 3.8/1.9 ms and α = 18°, bSSFP fMRI was performed and compared with the conventional cerebral blood volume-weighted fMRI using post-MION gradient echo and spin echo echo planar imaging. The results showed that post-MION bSSFP fMRI provides comparable sensitivity but with no severe image distortion and signal dropout. Robust negative responses were observed during stimulation and activation patterns were in excellent agreement with known neuroanatomy. Furthermore, the post-MION bSSFP signal was observed to decrease significantly during hypercapnia challenge, indicating its sensitivity to cerebral blood volume changes. These findings demonstrated that post-MION bSSFP fMRI is a promising alternative to conventional cerebral blood volume-weighted fMRI. This technique is particularly suited for fMRI investigation of animal models at high field. © 2011 Wiley Periodicals, Inc.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationMagnetic Resonance In Medicine, 2012, v. 68 n. 1, p. 65-73 [How to Cite?]
DOI: http://dx.doi.org/10.1002/mrm.23202
 
dc.identifier.doihttp://dx.doi.org/10.1002/mrm.23202
 
dc.identifier.epage73
 
dc.identifier.hkuros206797
 
dc.identifier.isiWOS:000305119100007
Funding AgencyGrant Number
Hong Kong Research Grant CouncilHKU7826/10M
Funding Information:

Grant sponsor: Hong Kong Research Grant Council; Grant number: HKU7826/10M.

 
dc.identifier.issn0740-3194
2013 Impact Factor: 3.398
 
dc.identifier.issue1
 
dc.identifier.pmid22127794
 
dc.identifier.scopuseid_2-s2.0-84862260827
 
dc.identifier.spage65
 
dc.identifier.urihttp://hdl.handle.net/10722/155771
 
dc.identifier.volume68
 
dc.languageeng
 
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0740-3194/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofMagnetic Resonance in Medicine
 
dc.relation.referencesReferences in Scopus
 
dc.subjectbSSFP
 
dc.subjectCBV
 
dc.subjectfMRI
 
dc.subjectIntravascular susceptibility contrast agent
 
dc.subjectMION
 
dc.subjectRat
 
dc.titleBalanced steady-state free precession fMRI with intravascular susceptibility contrast agent
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong