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Article: High fidelity tonotopic mapping using swept source functional magnetic resonance imaging

TitleHigh fidelity tonotopic mapping using swept source functional magnetic resonance imaging
Authors
KeywordsFmri
Inferior Colliculus
Tonotopy
Issue Date2012
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
Citation
Neuroimage, 2012, v. 61 n. 4, p. 978-986 How to Cite?
AbstractTonotopy, the topographic encoding of sound frequency, is the fundamental property of the auditory system. Invasive techniques lack the spatial coverage or frequency resolution to rigorously investigate tonotopy. Conventional auditory fMRI is corrupted by significant image distortion, sporadic acoustic noise and inadequate frequency resolution. We developed an efficient and high fidelity auditory fMRI method that integrates continuous frequency sweeping stimulus, distortion free MRI sequence with stable scanner noise and Fourier analysis. We demonstrated this swept source imaging (SSI) in the rat inferior colliculus and obtained tonotopic maps with ~. 2. kHz resolution and 40. kHz bandwidth. The results were vastly superior to those obtained by conventional fMRI mapping approach and in excellent agreement with invasive findings. We applied SSI to examine tonotopic injury following developmental noise exposure and observed that the tonotopic organization was significantly disrupted. With SSI, we also observed the subtle effects of sound pressure level on tonotopic maps, reflecting the complex neuronal responses associated with asymmetric tuning curves. This in vivo and noninvasive technique will greatly facilitate future investigation of tonotopic plasticity and disorders and auditory information processing. SSI can also be adapted to study topographic organization in other sensory systems such as retinotopy and somatotopy. © 2012 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/155761
ISSN
2014 Impact Factor: 6.357
2014 SCImago Journal Rankings: 3.549
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU7826/10M
HKU7837/11M
Funding Information:

This work was supported by Hong Kong Research Grants Council (General research grants HKU7826/10M and HKU7837/11M to E.X.W.).

References

 

DC FieldValueLanguage
dc.contributor.authorCheung, MMen_HK
dc.contributor.authorLau, Cen_HK
dc.contributor.authorZhou, IYen_HK
dc.contributor.authorChan, KCen_HK
dc.contributor.authorZhang, JWen_HK
dc.contributor.authorFan, SJen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2012-08-08T08:35:13Z-
dc.date.available2012-08-08T08:35:13Z-
dc.date.issued2012en_HK
dc.identifier.citationNeuroimage, 2012, v. 61 n. 4, p. 978-986en_HK
dc.identifier.issn1053-8119en_HK
dc.identifier.urihttp://hdl.handle.net/10722/155761-
dc.description.abstractTonotopy, the topographic encoding of sound frequency, is the fundamental property of the auditory system. Invasive techniques lack the spatial coverage or frequency resolution to rigorously investigate tonotopy. Conventional auditory fMRI is corrupted by significant image distortion, sporadic acoustic noise and inadequate frequency resolution. We developed an efficient and high fidelity auditory fMRI method that integrates continuous frequency sweeping stimulus, distortion free MRI sequence with stable scanner noise and Fourier analysis. We demonstrated this swept source imaging (SSI) in the rat inferior colliculus and obtained tonotopic maps with ~. 2. kHz resolution and 40. kHz bandwidth. The results were vastly superior to those obtained by conventional fMRI mapping approach and in excellent agreement with invasive findings. We applied SSI to examine tonotopic injury following developmental noise exposure and observed that the tonotopic organization was significantly disrupted. With SSI, we also observed the subtle effects of sound pressure level on tonotopic maps, reflecting the complex neuronal responses associated with asymmetric tuning curves. This in vivo and noninvasive technique will greatly facilitate future investigation of tonotopic plasticity and disorders and auditory information processing. SSI can also be adapted to study topographic organization in other sensory systems such as retinotopy and somatotopy. © 2012 Elsevier Inc.en_HK
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimgen_HK
dc.relation.ispartofNeuroImageen_HK
dc.subjectFmrien_US
dc.subjectInferior Colliculusen_US
dc.subjectTonotopyen_US
dc.subject.meshAcoustic Stimulationen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAuditory Perception - physiologyen_HK
dc.subject.meshBrain Mapping - methodsen_HK
dc.subject.meshImage Processing, Computer-Assisted - methodsen_HK
dc.subject.meshInferior Colliculi - physiologyen_HK
dc.subject.meshMagnetic Resonance Imaging - methodsen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.titleHigh fidelity tonotopic mapping using swept source functional magnetic resonance imagingen_HK
dc.typeArticleen_HK
dc.identifier.emailZhou, IY: izhou@hku.hken_HK
dc.identifier.emailWu, EX: ewu1@hkucc.hku.hken_HK
dc.identifier.authorityZhou, IY=rp01739en_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.neuroimage.2012.03.031en_HK
dc.identifier.pmid22445952-
dc.identifier.scopuseid_2-s2.0-84861331599en_HK
dc.identifier.hkuros225431-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84861331599&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume61en_HK
dc.identifier.issue4en_HK
dc.identifier.spage978en_HK
dc.identifier.epage986en_HK
dc.identifier.eissn1095-9572-
dc.identifier.isiWOS:000305920600026-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheung, MM=24333907800en_HK
dc.identifier.scopusauthoridLau, C=36655866600en_HK
dc.identifier.scopusauthoridZhou, IY=35424838500en_HK
dc.identifier.scopusauthoridChan, KC=34968940300en_HK
dc.identifier.scopusauthoridZhang, JW=54979931500en_HK
dc.identifier.scopusauthoridFan, SJ=36514618100en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK
dc.identifier.citeulike10701608-

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