File Download
  • No File Attached
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Effect of cerebrovascular changes on brain DTI quantitation: a hypercapnia study
  • Basic View
  • Metadata View
  • XML View
TitleEffect of cerebrovascular changes on brain DTI quantitation: a hypercapnia study
 
AuthorsDing, AY1
Chan, KC1
Wu, EX1
 
KeywordsCerebrovasculature
Diffusivity
Dti
Hemodynamics
Hypercapnia
Quantitation
 
Issue Date2012
 
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/mri
 
CitationMagnetic Resonance Imaging, 2012 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.mri.2012.02.012
 
AbstractQuantitative diffusion tensor imaging (DTI) offers a valuable tool to probe the microstructural changes in neural tissues in vivo, where absolute quantitation accuracy and reproducibility are essential. It has been long recognized that measurement of apparent diffusion coefficient (ADC) using DTI could be influenced by the presence of water molecules in cerebrovasculature. However, little is known about to what extent such blood signal affects DTI quantitation. In this study, we quantitatively examined the effect of cerebral hemodynamic change on DTI indices by using a standard multislice echo planar imaging (EPI) spin echo (SE) DTI acquisition protocol and a rat model of hypercapnia. In response to 5% CO 2 challenge, mean, radial and axial diffusivities measured with diffusion factor (b-value) of b=1.0 ms/μm 2 were found to increase in whole brain (1.52%±0.22%, 1.66%±0.16% and 1.35%±0.37%, respectively), gray matter (1.56%±0.23%, 1.63%±0.14% and 1.47%±0.45%, respectively) and white matter regions (1.45%±0.28%, 1.88%±0.33% and 1.10%±0.26%, respectively). Fractional anisotropy (FA) was found to decrease by 1.67%±0.38%, 1.91%±0.59% and 1.46%±0.30% in whole brain, gray matter and white matter regions, respectively. In addition, these diffusivity increases and FA decreases became more pronounced at a lower b-value (b=0.3 ms/μm 2). The results indicated that in vivo DTI quantitation in brain can be contaminated by vascular factors on the order of few percentages. Consequently, alterations in cerebrovasculature and hemodynamics can affect the DTI quantitation and its efficacy in characterizing the neural tissue microstructures in normal and diseased states. Caution should be taken in designing and interpreting quantitative DTI studies as all DTI indices can be potentially confounded by physiologic conditions and by cerebrovascular and hemodynamic characteristics. © 2012 Elsevier Inc. All rights reserved.
 
ISSN0730-725X
2013 Impact Factor: 2.022
2013 SCImago Journal Rankings: 0.978
 
DOIhttp://dx.doi.org/10.1016/j.mri.2012.02.012
 
DC FieldValue
dc.contributor.authorDing, AY
 
dc.contributor.authorChan, KC
 
dc.contributor.authorWu, EX
 
dc.date.accessioned2012-08-08T08:35:08Z
 
dc.date.available2012-08-08T08:35:08Z
 
dc.date.issued2012
 
dc.description.abstractQuantitative diffusion tensor imaging (DTI) offers a valuable tool to probe the microstructural changes in neural tissues in vivo, where absolute quantitation accuracy and reproducibility are essential. It has been long recognized that measurement of apparent diffusion coefficient (ADC) using DTI could be influenced by the presence of water molecules in cerebrovasculature. However, little is known about to what extent such blood signal affects DTI quantitation. In this study, we quantitatively examined the effect of cerebral hemodynamic change on DTI indices by using a standard multislice echo planar imaging (EPI) spin echo (SE) DTI acquisition protocol and a rat model of hypercapnia. In response to 5% CO 2 challenge, mean, radial and axial diffusivities measured with diffusion factor (b-value) of b=1.0 ms/μm 2 were found to increase in whole brain (1.52%±0.22%, 1.66%±0.16% and 1.35%±0.37%, respectively), gray matter (1.56%±0.23%, 1.63%±0.14% and 1.47%±0.45%, respectively) and white matter regions (1.45%±0.28%, 1.88%±0.33% and 1.10%±0.26%, respectively). Fractional anisotropy (FA) was found to decrease by 1.67%±0.38%, 1.91%±0.59% and 1.46%±0.30% in whole brain, gray matter and white matter regions, respectively. In addition, these diffusivity increases and FA decreases became more pronounced at a lower b-value (b=0.3 ms/μm 2). The results indicated that in vivo DTI quantitation in brain can be contaminated by vascular factors on the order of few percentages. Consequently, alterations in cerebrovasculature and hemodynamics can affect the DTI quantitation and its efficacy in characterizing the neural tissue microstructures in normal and diseased states. Caution should be taken in designing and interpreting quantitative DTI studies as all DTI indices can be potentially confounded by physiologic conditions and by cerebrovascular and hemodynamic characteristics. © 2012 Elsevier Inc. All rights reserved.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationMagnetic Resonance Imaging, 2012 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.mri.2012.02.012
 
dc.identifier.citeulike10551703
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.mri.2012.02.012
 
dc.identifier.hkuros225430
 
dc.identifier.issn0730-725X
2013 Impact Factor: 2.022
2013 SCImago Journal Rankings: 0.978
 
dc.identifier.pmid22495243
 
dc.identifier.scopuseid_2-s2.0-84864006582
 
dc.identifier.urihttp://hdl.handle.net/10722/155745
 
dc.languageeng
 
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/mri
 
dc.publisher.placeUnited States
 
dc.relation.ispartofMagnetic Resonance Imaging
 
dc.subjectCerebrovasculature
 
dc.subjectDiffusivity
 
dc.subjectDti
 
dc.subjectHemodynamics
 
dc.subjectHypercapnia
 
dc.subjectQuantitation
 
dc.titleEffect of cerebrovascular changes on brain DTI quantitation: a hypercapnia study
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Ding, AY</contributor.author>
<contributor.author>Chan, KC</contributor.author>
<contributor.author>Wu, EX</contributor.author>
<date.accessioned>2012-08-08T08:35:08Z</date.accessioned>
<date.available>2012-08-08T08:35:08Z</date.available>
<date.issued>2012</date.issued>
<identifier.citation>Magnetic Resonance Imaging, 2012</identifier.citation>
<identifier.issn>0730-725X</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/155745</identifier.uri>
<description.abstract>Quantitative diffusion tensor imaging (DTI) offers a valuable tool to probe the microstructural changes in neural tissues in vivo, where absolute quantitation accuracy and reproducibility are essential. It has been long recognized that measurement of apparent diffusion coefficient (ADC) using DTI could be influenced by the presence of water molecules in cerebrovasculature. However, little is known about to what extent such blood signal affects DTI quantitation. In this study, we quantitatively examined the effect of cerebral hemodynamic change on DTI indices by using a standard multislice echo planar imaging (EPI) spin echo (SE) DTI acquisition protocol and a rat model of hypercapnia. In response to 5% CO 2 challenge, mean, radial and axial diffusivities measured with diffusion factor (b-value) of b=1.0 ms/&#956;m 2 were found to increase in whole brain (1.52%&#177;0.22%, 1.66%&#177;0.16% and 1.35%&#177;0.37%, respectively), gray matter (1.56%&#177;0.23%, 1.63%&#177;0.14% and 1.47%&#177;0.45%, respectively) and white matter regions (1.45%&#177;0.28%, 1.88%&#177;0.33% and 1.10%&#177;0.26%, respectively). Fractional anisotropy (FA) was found to decrease by 1.67%&#177;0.38%, 1.91%&#177;0.59% and 1.46%&#177;0.30% in whole brain, gray matter and white matter regions, respectively. In addition, these diffusivity increases and FA decreases became more pronounced at a lower b-value (b=0.3 ms/&#956;m 2). The results indicated that in vivo DTI quantitation in brain can be contaminated by vascular factors on the order of few percentages. Consequently, alterations in cerebrovasculature and hemodynamics can affect the DTI quantitation and its efficacy in characterizing the neural tissue microstructures in normal and diseased states. Caution should be taken in designing and interpreting quantitative DTI studies as all DTI indices can be potentially confounded by physiologic conditions and by cerebrovascular and hemodynamic characteristics. &#169; 2012 Elsevier Inc. All rights reserved.</description.abstract>
<language>eng</language>
<publisher>Elsevier Inc. The Journal&apos;s web site is located at http://www.elsevier.com/locate/mri</publisher>
<relation.ispartof>Magnetic Resonance Imaging</relation.ispartof>
<subject>Cerebrovasculature</subject>
<subject>Diffusivity</subject>
<subject>Dti</subject>
<subject>Hemodynamics</subject>
<subject>Hypercapnia</subject>
<subject>Quantitation</subject>
<title>Effect of cerebrovascular changes on brain DTI quantitation: a hypercapnia study</title>
<type>Article</type>
<description.nature>link_to_subscribed_fulltext</description.nature>
<identifier.doi>10.1016/j.mri.2012.02.012</identifier.doi>
<identifier.pmid>22495243</identifier.pmid>
<identifier.scopus>eid_2-s2.0-84864006582</identifier.scopus>
<identifier.hkuros>225430</identifier.hkuros>
<publisher.place>United States</publisher.place>
<identifier.citeulike>10551703</identifier.citeulike>
</item>
Author Affiliations
  1. The University of Hong Kong