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Article: BOLD fMRI investigation of the rat auditory pathway and tonotopic organization

TitleBOLD fMRI investigation of the rat auditory pathway and tonotopic organization
Authors
KeywordsAuditory system
Blood oxygenation level dependent functional MRI
Inferior colliculus
Rat
Tonotopy
Issue Date2012
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
Citation
Neuroimage, 2012, v. 60 n. 2, p. 1205-1211 How to Cite?
Abstract
Rodents share general anatomical, physiological and behavioral features in the central auditory system with humans. In this study, monaural broadband noise and pure tone sounds are presented to normal rats and the resulting hemodynamic responses are measured with blood oxygenation level-dependent (BOLD) fMRI using a standard spin-echo echo planar imaging sequence (without sparse temporal sampling). The cochlear nucleus (CN), superior olivary complex, lateral lemniscus, inferior colliculus (IC), medial geniculate body and primary auditory cortex, all major auditory structures, are activated by broadband stimulation. The CN and IC BOLD signal changes increase monotonically with sound pressure level. Pure tone stimulation with three distinct frequencies (7, 20 and 40. kHz) reveals the tonotopic organization of the IC. The activated regions shift from dorsolateral to ventromedial IC with increasing frequency. These results agree with electrophysiology and immunohistochemistry findings, indicating the feasibility of auditory fMRI in rats. This is the first fMRI study of the rodent ascending auditory pathway. © 2012 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/155728
ISSN
2013 Impact Factor: 6.132
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU7837/11M
Funding Information:

This work was supported in part by Hong Kong Research Grants Council (HKU7837/11M).

References

 

DC FieldValueLanguage
dc.contributor.authorCheung, MMen_HK
dc.contributor.authorLau, Cen_HK
dc.contributor.authorZhou, IYen_HK
dc.contributor.authorChan, KCen_HK
dc.contributor.authorCheng, JSen_HK
dc.contributor.authorZhang, JWen_HK
dc.contributor.authorHo, LCen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2012-08-08T08:35:02Z-
dc.date.available2012-08-08T08:35:02Z-
dc.date.issued2012en_HK
dc.identifier.citationNeuroimage, 2012, v. 60 n. 2, p. 1205-1211en_HK
dc.identifier.issn1053-8119en_HK
dc.identifier.urihttp://hdl.handle.net/10722/155728-
dc.description.abstractRodents share general anatomical, physiological and behavioral features in the central auditory system with humans. In this study, monaural broadband noise and pure tone sounds are presented to normal rats and the resulting hemodynamic responses are measured with blood oxygenation level-dependent (BOLD) fMRI using a standard spin-echo echo planar imaging sequence (without sparse temporal sampling). The cochlear nucleus (CN), superior olivary complex, lateral lemniscus, inferior colliculus (IC), medial geniculate body and primary auditory cortex, all major auditory structures, are activated by broadband stimulation. The CN and IC BOLD signal changes increase monotonically with sound pressure level. Pure tone stimulation with three distinct frequencies (7, 20 and 40. kHz) reveals the tonotopic organization of the IC. The activated regions shift from dorsolateral to ventromedial IC with increasing frequency. These results agree with electrophysiology and immunohistochemistry findings, indicating the feasibility of auditory fMRI in rats. This is the first fMRI study of the rodent ascending auditory pathway. © 2012 Elsevier Inc.en_HK
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimgen_HK
dc.relation.ispartofNeuroImageen_HK
dc.subjectAuditory systemen_HK
dc.subjectBlood oxygenation level dependent functional MRIen_HK
dc.subjectInferior colliculusen_HK
dc.subjectRaten_HK
dc.subjectTonotopyen_HK
dc.subject.meshAuditory Pathways - anatomy and histology - physiology-
dc.subject.meshInferior Colliculi - anatomy and histology - physiology-
dc.subject.meshMagnetic Resonance Imaging - methods-
dc.subject.meshOxygen - blood-
dc.subject.meshRats, Sprague-Dawley-
dc.titleBOLD fMRI investigation of the rat auditory pathway and tonotopic organizationen_HK
dc.typeArticleen_HK
dc.identifier.emailZhou, IY: izhou@hku.hken_HK
dc.identifier.emailWu, EX: ewu1@hkucc.hku.hken_HK
dc.identifier.authorityZhou, IY=rp01739en_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.neuroimage.2012.01.087en_HK
dc.identifier.pmid22297205en_HK
dc.identifier.scopuseid_2-s2.0-84862777701en_HK
dc.identifier.hkuros206792-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84862777701&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume60en_HK
dc.identifier.issue2en_HK
dc.identifier.spage1205en_HK
dc.identifier.epage1211en_HK
dc.identifier.isiWOS:000303272300037-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheung, MM=24333907800en_HK
dc.identifier.scopusauthoridLau, C=36655866600en_HK
dc.identifier.scopusauthoridZhou, IY=35424838500en_HK
dc.identifier.scopusauthoridChan, KC=34968940300en_HK
dc.identifier.scopusauthoridCheng, JS=55443910700en_HK
dc.identifier.scopusauthoridZhang, JW=54979931500en_HK
dc.identifier.scopusauthoridHo, LC=55262279300en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK
dc.identifier.citeulike10312795-

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