File Download
  • No File Attached
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: BOLD fMRI investigation of the rat auditory pathway and tonotopic organization
  • Basic View
  • Metadata View
  • XML View
TitleBOLD fMRI investigation of the rat auditory pathway and tonotopic organization
 
AuthorsCheung, MM1
Lau, C1
Zhou, IY1
Chan, KC3 1 2
Cheng, JS1
Zhang, JW1
Ho, LC1
Wu, EX1
 
KeywordsAuditory system
Blood oxygenation level dependent functional MRI
Inferior colliculus
Rat
Tonotopy
 
Issue Date2012
 
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
 
CitationNeuroimage, 2012, v. 60 n. 2, p. 1205-1211 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.neuroimage.2012.01.087
 
AbstractRodents share general anatomical, physiological and behavioral features in the central auditory system with humans. In this study, monaural broadband noise and pure tone sounds are presented to normal rats and the resulting hemodynamic responses are measured with blood oxygenation level-dependent (BOLD) fMRI using a standard spin-echo echo planar imaging sequence (without sparse temporal sampling). The cochlear nucleus (CN), superior olivary complex, lateral lemniscus, inferior colliculus (IC), medial geniculate body and primary auditory cortex, all major auditory structures, are activated by broadband stimulation. The CN and IC BOLD signal changes increase monotonically with sound pressure level. Pure tone stimulation with three distinct frequencies (7, 20 and 40. kHz) reveals the tonotopic organization of the IC. The activated regions shift from dorsolateral to ventromedial IC with increasing frequency. These results agree with electrophysiology and immunohistochemistry findings, indicating the feasibility of auditory fMRI in rats. This is the first fMRI study of the rodent ascending auditory pathway. © 2012 Elsevier Inc.
 
ISSN1053-8119
2013 Impact Factor: 6.132
 
DOIhttp://dx.doi.org/10.1016/j.neuroimage.2012.01.087
 
ISI Accession Number IDWOS:000303272300037
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU7837/11M
Funding Information:

This work was supported in part by Hong Kong Research Grants Council (HKU7837/11M).

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorCheung, MM
 
dc.contributor.authorLau, C
 
dc.contributor.authorZhou, IY
 
dc.contributor.authorChan, KC
 
dc.contributor.authorCheng, JS
 
dc.contributor.authorZhang, JW
 
dc.contributor.authorHo, LC
 
dc.contributor.authorWu, EX
 
dc.date.accessioned2012-08-08T08:35:02Z
 
dc.date.available2012-08-08T08:35:02Z
 
dc.date.issued2012
 
dc.description.abstractRodents share general anatomical, physiological and behavioral features in the central auditory system with humans. In this study, monaural broadband noise and pure tone sounds are presented to normal rats and the resulting hemodynamic responses are measured with blood oxygenation level-dependent (BOLD) fMRI using a standard spin-echo echo planar imaging sequence (without sparse temporal sampling). The cochlear nucleus (CN), superior olivary complex, lateral lemniscus, inferior colliculus (IC), medial geniculate body and primary auditory cortex, all major auditory structures, are activated by broadband stimulation. The CN and IC BOLD signal changes increase monotonically with sound pressure level. Pure tone stimulation with three distinct frequencies (7, 20 and 40. kHz) reveals the tonotopic organization of the IC. The activated regions shift from dorsolateral to ventromedial IC with increasing frequency. These results agree with electrophysiology and immunohistochemistry findings, indicating the feasibility of auditory fMRI in rats. This is the first fMRI study of the rodent ascending auditory pathway. © 2012 Elsevier Inc.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationNeuroimage, 2012, v. 60 n. 2, p. 1205-1211 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.neuroimage.2012.01.087
 
dc.identifier.citeulike10312795
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.neuroimage.2012.01.087
 
dc.identifier.epage1211
 
dc.identifier.hkuros206792
 
dc.identifier.isiWOS:000303272300037
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU7837/11M
Funding Information:

This work was supported in part by Hong Kong Research Grants Council (HKU7837/11M).

 
dc.identifier.issn1053-8119
2013 Impact Factor: 6.132
 
dc.identifier.issue2
 
dc.identifier.pmid22297205
 
dc.identifier.scopuseid_2-s2.0-84862777701
 
dc.identifier.spage1205
 
dc.identifier.urihttp://hdl.handle.net/10722/155728
 
dc.identifier.volume60
 
dc.languageeng
 
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
 
dc.publisher.placeUnited States
 
dc.relation.ispartofNeuroImage
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAuditory Pathways - anatomy and histology - physiology
 
dc.subject.meshInferior Colliculi - anatomy and histology - physiology
 
dc.subject.meshMagnetic Resonance Imaging - methods
 
dc.subject.meshOxygen - blood
 
dc.subject.meshRats, Sprague-Dawley
 
dc.subjectAuditory system
 
dc.subjectBlood oxygenation level dependent functional MRI
 
dc.subjectInferior colliculus
 
dc.subjectRat
 
dc.subjectTonotopy
 
dc.titleBOLD fMRI investigation of the rat auditory pathway and tonotopic organization
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Cheung, MM</contributor.author>
<contributor.author>Lau, C</contributor.author>
<contributor.author>Zhou, IY</contributor.author>
<contributor.author>Chan, KC</contributor.author>
<contributor.author>Cheng, JS</contributor.author>
<contributor.author>Zhang, JW</contributor.author>
<contributor.author>Ho, LC</contributor.author>
<contributor.author>Wu, EX</contributor.author>
<date.accessioned>2012-08-08T08:35:02Z</date.accessioned>
<date.available>2012-08-08T08:35:02Z</date.available>
<date.issued>2012</date.issued>
<identifier.citation>Neuroimage, 2012, v. 60 n. 2, p. 1205-1211</identifier.citation>
<identifier.issn>1053-8119</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/155728</identifier.uri>
<description.abstract>Rodents share general anatomical, physiological and behavioral features in the central auditory system with humans. In this study, monaural broadband noise and pure tone sounds are presented to normal rats and the resulting hemodynamic responses are measured with blood oxygenation level-dependent (BOLD) fMRI using a standard spin-echo echo planar imaging sequence (without sparse temporal sampling). The cochlear nucleus (CN), superior olivary complex, lateral lemniscus, inferior colliculus (IC), medial geniculate body and primary auditory cortex, all major auditory structures, are activated by broadband stimulation. The CN and IC BOLD signal changes increase monotonically with sound pressure level. Pure tone stimulation with three distinct frequencies (7, 20 and 40. kHz) reveals the tonotopic organization of the IC. The activated regions shift from dorsolateral to ventromedial IC with increasing frequency. These results agree with electrophysiology and immunohistochemistry findings, indicating the feasibility of auditory fMRI in rats. This is the first fMRI study of the rodent ascending auditory pathway. &#169; 2012 Elsevier Inc.</description.abstract>
<language>eng</language>
<publisher>Academic Press. The Journal&apos;s web site is located at http://www.elsevier.com/locate/ynimg</publisher>
<relation.ispartof>NeuroImage</relation.ispartof>
<subject>Auditory system</subject>
<subject>Blood oxygenation level dependent functional MRI</subject>
<subject>Inferior colliculus</subject>
<subject>Rat</subject>
<subject>Tonotopy</subject>
<subject.mesh>Auditory Pathways - anatomy and histology - physiology</subject.mesh>
<subject.mesh>Inferior Colliculi - anatomy and histology - physiology</subject.mesh>
<subject.mesh>Magnetic Resonance Imaging - methods</subject.mesh>
<subject.mesh>Oxygen - blood</subject.mesh>
<subject.mesh>Rats, Sprague-Dawley</subject.mesh>
<title>BOLD fMRI investigation of the rat auditory pathway and tonotopic organization</title>
<type>Article</type>
<description.nature>link_to_subscribed_fulltext</description.nature>
<identifier.doi>10.1016/j.neuroimage.2012.01.087</identifier.doi>
<identifier.pmid>22297205</identifier.pmid>
<identifier.scopus>eid_2-s2.0-84862777701</identifier.scopus>
<identifier.hkuros>206792</identifier.hkuros>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-84862777701&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>60</identifier.volume>
<identifier.issue>2</identifier.issue>
<identifier.spage>1205</identifier.spage>
<identifier.epage>1211</identifier.epage>
<identifier.isi>WOS:000303272300037</identifier.isi>
<publisher.place>United States</publisher.place>
<identifier.citeulike>10312795</identifier.citeulike>
</item>
Author Affiliations
  1. The University of Hong Kong
  2. Carnegie Mellon University
  3. University of Pittsburgh