Article: BOLD fMRI investigation of the rat auditory pathway and tonotopic organization

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TitleBOLD fMRI investigation of the rat auditory pathway and tonotopic organization
AuthorsCheung, MM
Lau, C
Zhou, IY
Chan, KC
Cheng, JS
Zhang, JW
Ho, LC
Wu, EX
KeywordsAuditory system
Blood oxygenation level dependent functional MRI
Inferior colliculus
Rat
Tonotopy
Issue Date2012
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
CitationNeuroimage, 2012, v. 60 n. 2, p. 1205-1211 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.neuroimage.2012.01.087
AbstractRodents share general anatomical, physiological and behavioral features in the central auditory system with humans. In this study, monaural broadband noise and pure tone sounds are presented to normal rats and the resulting hemodynamic responses are measured with blood oxygenation level-dependent (BOLD) fMRI using a standard spin-echo echo planar imaging sequence (without sparse temporal sampling). The cochlear nucleus (CN), superior olivary complex, lateral lemniscus, inferior colliculus (IC), medial geniculate body and primary auditory cortex, all major auditory structures, are activated by broadband stimulation. The CN and IC BOLD signal changes increase monotonically with sound pressure level. Pure tone stimulation with three distinct frequencies (7, 20 and 40. kHz) reveals the tonotopic organization of the IC. The activated regions shift from dorsolateral to ventromedial IC with increasing frequency. These results agree with electrophysiology and immunohistochemistry findings, indicating the feasibility of auditory fMRI in rats. This is the first fMRI study of the rodent ascending auditory pathway. © 2012 Elsevier Inc.
ISSN1053-8119
2011 Impact Factor: 5.895
2011 SCImago Journal Rankings: 0.450
DOIhttp://dx.doi.org/10.1016/j.neuroimage.2012.01.087
ISI Accession Number IDWOS:000303272300037
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU7837/11M
Funding Information:

This work was supported in part by Hong Kong Research Grants Council (HKU7837/11M).

ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorCheung, MM
dc.contributor.authorLau, C
dc.contributor.authorZhou, IY
dc.contributor.authorChan, KC
dc.contributor.authorCheng, JS
dc.contributor.authorZhang, JW
dc.contributor.authorHo, LC
dc.contributor.authorWu, EX
dc.date.accessioned2012-08-08T08:35:02Z
dc.date.available2012-08-08T08:35:02Z
dc.date.issued2012
dc.description.abstractRodents share general anatomical, physiological and behavioral features in the central auditory system with humans. In this study, monaural broadband noise and pure tone sounds are presented to normal rats and the resulting hemodynamic responses are measured with blood oxygenation level-dependent (BOLD) fMRI using a standard spin-echo echo planar imaging sequence (without sparse temporal sampling). The cochlear nucleus (CN), superior olivary complex, lateral lemniscus, inferior colliculus (IC), medial geniculate body and primary auditory cortex, all major auditory structures, are activated by broadband stimulation. The CN and IC BOLD signal changes increase monotonically with sound pressure level. Pure tone stimulation with three distinct frequencies (7, 20 and 40. kHz) reveals the tonotopic organization of the IC. The activated regions shift from dorsolateral to ventromedial IC with increasing frequency. These results agree with electrophysiology and immunohistochemistry findings, indicating the feasibility of auditory fMRI in rats. This is the first fMRI study of the rodent ascending auditory pathway. © 2012 Elsevier Inc.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationNeuroimage, 2012, v. 60 n. 2, p. 1205-1211 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.neuroimage.2012.01.087
dc.identifier.citeulike10312795
dc.identifier.doihttp://dx.doi.org/10.1016/j.neuroimage.2012.01.087
dc.identifier.epage1211
dc.identifier.hkuros206792
dc.identifier.isiWOS:000303272300037
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU7837/11M
Funding Information:

This work was supported in part by Hong Kong Research Grants Council (HKU7837/11M).

dc.identifier.issn1053-8119
2011 Impact Factor: 5.895
2011 SCImago Journal Rankings: 0.450
dc.identifier.issue2
dc.identifier.pmid22297205
dc.identifier.scopuseid_2-s2.0-84862777701
dc.identifier.spage1205
dc.identifier.urihttp://hdl.handle.net/10722/155728
dc.identifier.volume60
dc.languageeng
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
dc.publisher.placeUnited States
dc.relation.ispartofNeuroImage
dc.relation.referencesReferences in Scopus
dc.subject.meshAuditory Pathways - anatomy and histology - physiology
dc.subject.meshInferior Colliculi - anatomy and histology - physiology
dc.subject.meshMagnetic Resonance Imaging - methods
dc.subject.meshOxygen - blood
dc.subject.meshRats, Sprague-Dawley
dc.subjectAuditory system
dc.subjectBlood oxygenation level dependent functional MRI
dc.subjectInferior colliculus
dc.subjectRat
dc.subjectTonotopy
dc.titleBOLD fMRI investigation of the rat auditory pathway and tonotopic organization
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Carnegie Mellon University
  3. University of Pittsburgh